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Assimilation Backfire

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The Assimilator is terrifying because of its virus-like ability to absorb people's body and mind into itself, creating a threat that can spread faster than a Zombie Apocalypse. However, The Assimilator's voracious and indiscriminate appetite may lead to it eating someone who proves Too Spicy for Yog-Sothoth. To keep the food metaphor, this person may well cause severe indigestion as they fight from the inside and take control back from the Assimilator, even to the point of usurping the title of Hive Queen.
Alternately, if You Are Who You Eat lets the Power Parasite steal another's powers (or even just regular Power Copying or cloning), then their theft may go horribly right when their Weaksauce Weakness is also stolen and allows enemies an easy way to defeat it. To make matters worse, the Assimilator probably has no idea it inherited the weakness or how to minimize it or stop it being exploited. Additionally, just having the power of another character does not grant the knowledge or skill to use it.
Both types aren't limited to just beings. Certain inanimate objects, such as glass, can be absorbed or copied to still apply for this trope. In those cases, the absorbed material presents a new weakness that allows opponents to more easily damage or manipulate the assimilator or limits the assimilator's abilities.
Compare No-Sell, where the attempted assimilation just plain fails, Feed It a Bomb, where a bomb is absorbed, and Transforming Conforming, where drawbacks occur after transformations in general. A kind of Phlebotinum Rebel. This could also be said to be what happens when you fail to hijack Cthulhu. See also Tricking the Shapeshifter, Trapped in the Host, and Copied the Morals, Too.
As this is a Death Trope, unmarked spoilers abound. Beware.
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Of a sort in Terminator 2: Judgment Day. The T-1000 takes the form of a policeman to search for John Connor, and this disguise works remarkably well, right up until he actually finds him. One of the kids it asks for information is John's friend, a fellow Delinquent who, after lying and saying that he doesn't know John, immediately runs back to warn him that a cop is looking for him. John bails immediately, and it's this which prevents the cyborg assassin from immediately killing him off.
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Abraxas (Hrodvitnon): In this Godzilla MonsterVerse fanfiction, MaNi/Elder Brother suffers this. Word of God reveals part of the reason he's so much more Ax-Crazy than when he was attached to Ghidorah is because of him merging himself with a Skullcrawler and absorbing some of its cognitive impulses. This makes MaNi Too Dumb to Live, but it unfortunately also makes him severely devoid of self-restraint when he gets violent with you.
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This is how Freddy Krueger dies in the fifth installment of A Nightmare on Elm Street. He's absorbed the souls of three of Alice's friends, and a vision of his mother spurs them on to tear him apart from the inside.
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Samurai Jack saw Jack pitted against Demongo, a high-ranking minion of Aku who had absorbed the souls of every warrior he defeated; when Jack defeated one, it retreated as a wisp into Demongo's vest of skulls, where he could re-summon it immediately. Just before he was overpowered, Jack had the bright idea of hitching a ride on one of the souls, where he freed them all from Demongo's spell and left the now-powerless demon to be curbstomped by his vengeful enemies.
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Even though Rogue from X-Men is not an assimilator proper, her absorption power has often enough resulted in this trope; e.g., absorbing a particularly strong personality may result in her control of her own body to the persona she absorbed. This happened with Spyral, for instance. She also sometimes had to struggle for control of her own body with some other personalities she absorbed, especially with that of Carol Danvers. Some powers, such as Cyclops' Eye Beams, are also harder to control than others.
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Sluggy Freelance:
The Borg Expy in an early strip run into this problem after assimilating Riff and Torg. "Since you have come among us, all we have done is drink fermented hops beverages and ogle scantily clad females. This has seriously jeopardized our goal of the all-collective. We've never had to do this before... We are kicking you out."
Done again with Dr. Crabtree, the Nanite Queen, who can assimilate people's knowledge by eating their brains...but gets infected with Sam Sein's stupidity when she tries it on him, and when she eats Christmas Elves' brains she starts unconsciously frolicking everywhere while singing "lolly la!"
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Bleach:
Subverted when the Vandenreich develops a method to steal Bankais. But Urahara develops a method to temporarily hollowfy Shinigami souls, so the Quincies get poisoned and the Bankais come back to their owners. Unfortunately, the Bankais were Power Limiters to the Quincies, preventing them to activate Quincy Vollständing. Now the stolen Bankais are back, the Sternenritters can fight the Shinigamis with their full power.
This also happens twice to people who try assimilating Nemu. First, Szayelapporo uses her body to regenerate himself after dying to Mayuri, but in doing so absorbed a drug that Mayuri placed in her, which causes And I Must Scream (unless properly diluted). Second, Pernida absorbs her body, which comes with a powerful Healing Factor, but doesn't get her brain, which served to control said Healing Factor and tamp it down to manageable levels. The out-of-control cell growth turned Pernida into a mass of cancer cells.
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Defied in 70-Seas: Grin takes great pains to avoid this, by looking for like-minded people and further grooming them until they're mentally similar enough for him to assimilate.
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A Certain Magical Index: Rensa is a cyborg who can copy esper powers, including those of the Level 5's. When she encounters Touma, she realizes that his right arm has a power (Imagine Breaker) that she doesn't, so after analyzing it, she tries to use it herself. Her arm explodes.
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In The Thing (1982), the Thing's assimilation and imitation of Vance Norris is so good that it even copied his bad heart. Thing!Norris has a heart attack during a stressful situation, leading to the doctor's attempts to resuscitate "him" with an electrical defibrillator. The Thing is forced to attack the doctor and expose itself to stop the painful electrical shocks.
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Grim Dawn: It's made explicit that the disembodied Aetherial spirits invading the world always acquire some traits from the people they possess, if that body was alive upon taking. This has both positive and negative connotations, in that the result can be all over the moral spectrum. Usually negative ones though, as those Weak-Willed enough to be taken by Aetherials without a struggle (not all of them are that strong at first) are either too bland to make much of an impression or outright evil, leading to monsters like Warden Krieg, who had to be reprimanded for unecessary cruelty by another Aetherial. And those who willingly enter a pact with an Aetherial, they're either very good sorts partnering with a rebel against the invasion... or the worst of the worst on both accounts, like Theodin Marcell, the Shaper of Flesh.
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In Spider-Man: No Way Home, during the initial confrontation between the Marvel Cinematic Universe Peter Parker and the Spider-Man Trilogy Doctor Octopus, one of Doc Ock's tentacles rips off a piece of Peter's suit and incorporates the suit's nanotech into itself. However, this makes the tentacles a part of the suit's device network, allowing Peter to take control of them and incapacitate Ock, rather than use the nanites against their original wearer.
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Rosario + Vampire: When Doppelgänger copies a person, he gets all their powers... and their weaknesses. He's defeated when he copies Moka, only for Tsukune to slap the rosary on him, weakening him enough for them to defeat.
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In the first movie, Ruri, one of the Big Bad's Co-Dragons, copies Miroku's Wind Tunnel for her own use. This trope hits Ruri hard when she later deliberately expands it to gain an edge over Miroku, only to quickly lose control of it and be consumed.
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The antagonists of JoJo's Bizarre Adventure: Battle Tendency, the Pillarmen, are vampiric superhumans who feed by absorbing others. The first Pillarman Santana tries this on Joseph Joestar after he thinks he knocked the latter unconscious (rendering his Ripple useless). Joseph wasn't unconscious and immediately let off a Ripple inside Santana's body, tearing him in half.
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In Wreck-It Ralph, the main villains include Cy-bugs, which take on the features of whatever they eat.
A Cy-bug eats King Candy, who is assimilated a little too well and becomes said Cy-bug's primary consciousness. Which later goes less well for King Candy, as he also inherited the Cy-bug's weakness: an unstoppable need to fly towards anything that looks like the game-over beacon from their home game, in this case, a volcanic eruption.
The Cy-bugs from Hero's Duty are metallic from eating the metal environment around them. When they are in Sugar Rush, they ate and become the candy from the game, making it easier for Ralph to simply smash them. Except for one Cy-Bug who became Nigh-Invulnerable by eating a jawbreaker.
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Justice League: "Tabula Rasa" introduces Amazo, who copies the powers of all the League's members while fighting them. Superman turns out to be a subversion; Amazo does inherit his weakness to kryptonite, much like Parasite, but surpasses it shortly afterward. Invoked by Martian Manhunter at the end when he allows Amazo to gain his telepathy, who then uses it to discover that Lex Luthor has been deceiving him, and basically calls off the conflict.
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In Season 3 of Star Trek: Picard copies of both Data's and Lore's minds are put into the postironic brain of an advanced new android. Initially separated by a partition, desperate circumstances force the removal of that partition, leading to a Battle in the Center of the Mind. Lore prevails easily, with Data not even resisting — but because Lore was compelled to steal Data's memories as trophies (just as Data expected) he effectively became Data.
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Naruto:
When Orochimaru tried to steal Sasuke's body, Sasuke reversed the process and absorbed him instead. This nearly backfired on Sasuke when he used up so much chakra fighting Itachi that Orochimaru managed to force his way back to the surface and manifest and it was only the fact Itachi gambled on this and intentionally did this so he could forcibly remove and seal Orochimaru away that he didn't get away with it.
Also, there's always the threat that the Tailed Beasts can take control of their hosts and go on a rampage. But a strong enough host can instead summon their power at will, and an even better host can make friends with their beast.
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Fullmetal Alchemist:
After Envy is reduced to a small slug-like creature, they're eventually swallowed by one of Father's zombie-like. A second later, it suddenly turns on one of the others and bites it, then starts to merge with it. The mass of flesh proceeds to devour the other zombies in the room before transforming into Envy's Shapeshifter Default Form.
An omake portrayed an alternate version of Pride absorbing Gluttony, where doing so made Pride chubby and ridiculous-looking.
After Pride absorbs Kimblee, he is finally defeated by Ed Elric due to Kimblee fighting him from the inside. Kimblee's prexisting homicidal insanity preventing him from going mad like the rest of the screaming souls within Pride's Philosopher's Stone.
At the end of the series, the Big Bad Father absorbs his Anti-Hero homunculus Greed, and his Ultimate Shield power with it. Having been previously defeated by Edward Elric, who figured out his extreme defensive abilities are merely carbon-based, Greed decides to turn his powers the other direction and turn Father's body into pathetic frail graphite, allowing the heroes to K.O. Father for good.
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Darkwing Duck has one episode where Negaduck absorbs all of the other main villains' powers. Megavolt, Liquidator, and Bushroot all give him considerable elemental powers, but their weaknesses as well—Megavolt's vulnerability to short-circuiting, Liquidator's weakness to being thickened with water-soluble materials (such as quick-drying cement), and Bushroot's extreme emotional sensitivity— which Darkwing and the de-powered villains exploit to defeat him. Additionally, Negaduck also absorbed Quackerjack's "powers", which just causes him to laugh uncontrollably at random. This is useless and really annoys Negaduck.
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RWBY:
Cinder is only able to become the Fall Maiden by murdering the current Fall Maiden, Amber, and using a special type of parasite Grimm, which absorbs the power and transfers it to her. As a result, she gains enormous power at the cost of becoming extremely vulnerable to Ruby's Silver-Eye power which exists to destroy Grimm. A brief exposure to it during the Battle of Beacon cripples her for an entire volume, where she has to relearn how to speak and is forced to wear a mask to hide the scarring on the left side of her face. During the Battle of Haven, it's revealed that her left arm was destroyed by Ruby and replaced with a Grimm arm. Although she can use it as she would any other arm, and it allows her to absorb Maiden power from other Maidens, the Grimm do not have Aura. As a result, her left arm is entirely unprotected by her Aura as a result of being incompatible. It also makes the left side of her body much more vulnerable to Ruby's power.
After possessing Neopolitan, the Curious Cat falls victim to this trope. Jaune, Weiss, Blake, and Yang decide to use the abilities of the leaves of the Great Tree to force them to re-live all of their regrets and bad memories. When the Curious Cat boasts about their immunity to the leaves, Jaune points out that while the cat is indeed immune to the leaves, Neo isn't. Cue the leaves taking effect, and the cat abandoning Neo's body. And Neo is not too happy about having been possessed.
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I'm the Grim Reaper: Long story short, Ashe the Reaper literally eats demons. Then he tried to eat the demons of all the other Reapers, which combined into a super-demon that overpowered him.
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In Cold Days, we find when Harry became the Winter Knight, his power is now directly linked to Queen Mab. Butters comments this grants that person a unique vulnerability to Harry, although the events of the book heavily imply that was precisely the desired goal, for Harry to act as an independent check and failsafe.
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The Dresden Files:
When the Red Court took Susan into their midst, it proved to be an interesting setback in Changes, when Harry causes a powerful death spell meant for him to genocide the entire Red Court, by backfiring the spell using Susan as a willing conduit.
Less by design, but the Corpsetaker gets burned by this in Ghost Story. She was in the middle of performing a Grand Theft Me, and the victim was fighting back. Then Morty the ectomancer shows up with a horde of wraiths. If the Corpsetaker had taken anyone else, she would have won. But it was her victim's ability to hold onto her that allowed Morty to give her the bum rush to Hell.
In Cold Days, we find when Harry became the Winter Knight, his power is now directly linked to Queen Mab. Butters comments this grants that person a unique vulnerability to Harry, although the events of the book heavily imply that was precisely the desired goal, for Harry to act as an independent check and failsafe.
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Castiel absorbed all the souls of Purgatory in the season 6 finale of Supernatural. Unfortunately, included in those souls were not just human souls, but those of Leviathans.
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Jade in "Tennyo Goes to Hell" of the Whateley Universe. She's already a shapeshifter (sort of) who has the power to integrate her own memories (it's complicated), so when she gets attacked by an unstoppable Eldritch Abomination, she ends up with the power set of a shoggoth, making her the most terrifying thing in their reality.
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In the last episode of The Secret Saturdays, V.V. Argost has assimilated the Kur powers from Zak's Evil Twin from an anti-matter Mirror Universe, and then does the same to Zak himself to become even more powerful. But what Argost didn't realize (but Zak did) was what happens when matter and anti-matter combine, and Argost obliterates himself instead.
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In the Discworld novel Carpe Jugulum, the Magpyrs suck Granny Weatherwax's blood and attempt to turn her. She survives the experience without becoming a vampire; the Magpyrs aren't so lucky, however, as feeding on Granny Weatherwax has allowed her to turn them. By the end, they're craving tea instead of blood and even talking like her.
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Kid Icarus: Uprising provides a variation with the Aurum, which are a race of robotic aliens that tear planets apart as raw material and will capture native lifeforms to create robotic copies to fuel their war machine. However, it's mentioned in the Aurum Skuttler idol description that the Aurum will copy all fighting styles of the worlds they assimilate, even the weak ones. Sure enough, all the copied enemies created by the Aurum share the very same attack patterns and weaknesses of the originals with no attempt to improve on them.
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Justice League Action: In "Boo-ray For Bizarro", Amazo copies the powers and intelligence of superpowered beings. When he tries this on Bizarro, Bizarro's backwards logic conflicts with his computer brain, overloading and destroying him.
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In Inuyasha, this is how Moryomaru and the Infant are defeated by Naraku. Generally speaking, doing this to Naraku's never a good idea.
It's Naraku's Origin Story, he was human but was gravely injured and when a horde of demons came to consume him he used dark magic to merge with them.
In the first movie, Ruri, one of the Big Bad's Co-Dragons, copies Miroku's Wind Tunnel for her own use. This trope hits Ruri hard when she later deliberately expands it to gain an edge over Miroku, only to quickly lose control of it and be consumed.
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Static Shock: The metahuman Power Parasite Leech is defeated with water after he absorbed Static's powers.
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Homestuck: Sburb players create their sprites by "prototyping" various items, with a preference for corpses. Sburb underlings, as well as the wielders of the rings of the queens of Prospit and Derse, will subsequently gain the powers of these items - and the weaknesses. This trope has occurred several times, with varying degrees of success:
When John prototyped a doll missing an arm and an eye, Jack Noir loses those features when he steals and equips one of the rings. This did not slow him down much, unfortunately.
John tried to invoke this and completely incapacitate Jack by prototyping a doll missing its other arm and eye, but was prevented from doing so by Vriska, as crippling Jack would ruin the Stable Time Loop wherein Jack traveled back in time to ruin Vriska's Sburb session, which led to Vriska coming into contact with John in the first place.
When Becquerel was prototyped instead, Jack gained godlike Reality Warper powers - and an Undying Loyalty towards Jade that overruled his Omnicidal Maniac tendencies, in addition to other canine mannerisms like chasing cats.
Similarly when Jade ascended to God tier through her Bec-hybridized sprite, she became vulnerable to any psychic abilities that allow domination of animals, effectively turning her into their user's attack dog.
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Silverblade: When the Executioner possesses the Winged Avenger costume, it gains all of the superpowers the Avenger had possessed on the TV show. However, it also gains the Avenger's vulnerability to silver.
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Kamen Rider Drive has this as what happened to turn Mad Doctor Medic into such a monster. She has the powers to heal others by touch, but absorbs their emotions in the process, and healing a large number of villains in rapid succession caused their combined evil to overwhelm her mind. She's cured right at the very end when she heals The Hero and thus absorbs his goodness.
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Kamen Rider Ex-Aid Big Bad Kamen Rider Cronus absorbs the personification of the Gamedeus pandemic when his own Time Master powers prove insufficient to win. Merging with Gamedeus gives Cronus even greater powers, but introduces a humiliating weakness, as it means he's now vulnerable to the puny Level 1 forms that haven't been seen since the very beginning of the show, but are designed specifically for dealing with virus/human fusions. Worse yet, the damage from the fight causes Cronus to start losing his original powers as well after the merger breaks apart, allowing the heroes to swiftly finish him off.
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Kamen Rider Ghost has the Big Bad Adel given control of an array of immortal and self-evolving golems when he becomes king, which he learns to merge with into a combat-capable form of his own as part of a plan to assimilate everyone in the world. His abuse of their powers soon causes the golems to become sentient and slip the yoke of his control, at which point they absorb him and resume the plan with themselves in control.
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The Cybes, a Borg parody in the Space Arc of Irregular Webcomic!, who explicitly state they acquire the characteristics of those they assimilate (taking the Borg's "add your distinctiveness to our own" literally):
Iki Piki volunteers to be assimilated first, suggesting that his selfless sacrifice will mean the Cybe will duplicate his wish to save his comrades.
Eventually, they assimilate Serron. Immediately, they're all squabbling and trying to push each other out of the airlocks.
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In Rom vs. Transformers: Shining Armor, the above-mentioned Dire Wraiths discover they can assimilate Transformers like they can organic species. Unfortunately, the biomechanical nature of Transformers wrecks hell on the Wraith doing the possessing, resulting an insane, constantly mutating abomination that is quickly burned to death by its own out-of-control powers. Even when Vekktral figures out a way to do it safely, the victim (Ultra Magnus) is able to retain his individuality and fight Vekktral from the inside, something no organic creature could do.
Attempts to assimilate Space Knights also end horribly. In this case it's because the crystal armor Space Knights wear renders them immune to Wraith possession, allowing them to No-Sell it and kill any Wraith stupid enough to try.
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Superman: The Animated Series:
In "Feeding Time", Parasite takes Superman's power, but is defeated when he grabs a chunk of raw Kryptonite while Superman wore his Kryptonite-Proof Suit for the first time.
In "Two's a Crowd", Parasite agrees to help authorities find a bomb left by another villain by using his powers to access the other guy's memories. Instead, the other guy is so willful and egotistic that he temporarily takes over Parasite.
In "Double Dose", Parasite succeeds in stealing Superman's powers after teaming up with Livewire, then decides to doublecross her and steal hers too since her goal of murdering Superman conflicts with his. And unfortunately for him, he inherits her weakness to water, and is taken out when Superman tricks him into setting off the fire sprinklers, drenching him and shorting him out.
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In SUPERHOT: MIND CONTROL DELETE, the player character, Avar1ce, is one of the subjects of the Assimilation Plot from the first game. However, the System simply cannot keep up with Avar1ce's incessant desire for more. More bloodshed, more secrets, more power. Even in the endgame, when it tricks Avar1ce into deleting everything, Avar1ce refuses to give in. When Avar1ce finds a way to undelete everything, the System gives up and lets them have it.
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In Neverwinter Nights 2, if One of Many is in your party when you meet the dead god Myrkul, they'll ask you if they can eat Myrkul. Given that unlike the Knight-Captain's Spirit-Eater curse, One of Many adds consumed souls to its collective, Myrkul will take over, resulting in an Optional Boss.
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After obtaining their final power-up from Medusa and going completely off-board, Soul Eater's Crona attempts to devour Asura, the Kishin. It appears to work until Maka manages to knock Crona mentally off-balance, at which point Asura turns the tables on Crona and assimilates them from the inside, morphing Crona's body back into his own shape in front of Maka's eyes. Even later on though, this back-backfires on Asura, because Crona being inside let them reach BREW and the Book of Eibon, which Asura also swallowed, and used them to seal Asura away again.
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In Resident Evil 6 Derek Simmons's final giant insect form is practically immortal: whenever a limb is blown off, it will simply grab a nearby zombie, dismantle and absorb it and rebuild the limb. However, when attempting to heal its head, it grabs a zombie impaled on a lightning rod, which gets embedded in its eye and causes Simmons to get struck by lightning.
In Resident Evil: Outbreak File #2, Eldritch Abomination Nyx absorbs enormous amounts of dead biomass, including a Tyrant. However, for once Umbrella had a bright idea and installed a bomb in the Tyrant in case it went rogue. If you didn't use it against the Tyrant, it's possible to detonate it after Nyx has consumed it, dealing massive damage.
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In the "Neogenic Nightmare" arc of Spider-Man: The Animated Series, Spider-Man is attacked by the Vulture, a villain who uses advanced technology to steal vitality from others. Unfortunately for the Vulture, the mutation that gives Spider-Man his powers is particularly unstable at the time of the attack, and he absorbs some of Spider-Man's DNA, causing him to mutate into a monstrous man/spider hybrid.
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A delayed version in Star Trek: First Contact. Picard was assimilated and then later freed from the Borg Collective during the TV Series. This initially benefited the Borg, as they now have in-depth knowledge of Starfleet's tactics and technology, making an already formidable force stronger. However, in the movie, it is shown that Captain Picard also retained his in-depth knowledge of the Borg's behavior, tactics, technology, and weaknesses, and uses it to soundly defeat them several times. It didn't help them that the horrifying experience of assimilation made it personal for him and drove him to seek their destruction at all costs.
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In The Avengers: Earth's Mightiest Heroes, the Absorbing Man takes on the properties of Mjölnir. Too bad that one of those properties is being subject to the mental control of Thor.
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In a chapter of Azumanga Daioh, Tomo tells her friends what she would do if she had everyone's abilities (Sakaki's athleticism, Chiyo's intelligence, et cetera). In this Imagine Spot, she does a flying somersault into the classroom before instantly answering the question on the board. Unfortunately, she also assimilated Osaka's forgetfulness, so she does this in the middle of class (as she overslept), and she left at least one textbook at home. Tomo blames Osaka for making her fantasy "weird".
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In The Ghost Called Molly Mc Gee, In this AU, the Story Sprite is defeated by having it absorb a comic book, causing the creature to act like the superheroine the comic is about.
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In Ghost Rider (2007), Blackheart No Sells Blaze's Penance Stare power the first time it's used on him since he doesn't have a soul. When he draws the trapped souls of San Venganza into his body in a bid to increase his power, Blaze realizes that he's made himself vulnerable to the stare and uses it to destroy him.
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In the climax of Forbidden World, the crew attempt to defeat the alien invader by feeding it the cancer that another crew member was dying from.
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In the final episode of Weird Science, the alien invasion is thwarted at the last moment because they assimilate Gary and become too nice to attack.
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Vampire: The Masquerade has the art of diablerie, where one vampire can drink out another vampire's blood, and then their soul, gaining all of their powers. However, if the consumed vampire is of particularly strong mind and will, then said vampire just gets a new meat body. In the end game to the line, it's revealed this happened in slow-motion after the traitorous Tremere diablerized Saulot to gain his power, with Tremere's soul eventually kicked out of his body and having to find new accommodations.
Another example applies with Monty Coven, the 11th-generation Sabbat member who was lucky enough to find the body of 4th-generation demigod Mithras lying in torpor. At least, until the soul of Mithras objected. Rather than getting clobbered into oblivion, however, Monty's soul merged with Mithras's, creating a new amalgamation with Monty's modern insights and Mithras's millennia of tactical knowledge.
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The Replicators on Stargate SG-1 consume whatever materials are available to replicate. Normally they are drawn towards anything more advanced than they currently are, ignoring less advanced materials and technologies, but a single unit stranded in a low tech environment will still use what it can. This bit them in the ass when Thor's ship crashed in Earth's ocean. The lone survivor infiltrated a Russian sub where it was forced to replicate using steel instead of advanced Asgard alloys, rendering the new units susceptible to rust and short-circuiting in water.
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Fate/strange Fake: True Archer uses his Power Parasite Noble Phantasm Reincarnation Pandora to steal False Berserker's From Hell - a Phantasm that invokes Demon of Human Origin to transform the user into a demon. While this initially saves him from False Berserker's attack, when he tries using the transformation against their master, he realizes too late his usual A-Rank Magic Resistance doesn't cover him when he's transformed, and gets brutally mauled.
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A heroic example happens in GloomCookie, when Chrys devours the monster under Sebastian's bed, to protect him. The monster continues to live on inside of her, driving her to bring men home and eat them (as it had done to all the girls Sebastian brought home), until she figured out what was going on and vomited it back up.
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In Devilman, any human who retains his/her reason and pure heart can reverse Demonic Possession, granting them access to the demon's powers with only minor influence on their personality. The main character pulled this off on Amon, one of Hell's most powerful residents, becoming the eponymous Devilman.
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In Resident Evil: Outbreak File #2, Eldritch Abomination Nyx absorbs enormous amounts of dead biomass, including a Tyrant. However, for once Umbrella had a bright idea and installed a bomb in the Tyrant in case it went rogue. If you didn't use it against the Tyrant, it's possible to detonate it after Nyx has consumed it, dealing massive damage.
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In the Mass Effect setting the quarians' immune systems evolved to assimilate microbes rather than fight them, since Rannoch had none that were harmful. This is the main reason they wear those suits all the time, as foreign microbes don't share Rannochian microbes' friendliness.
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Spider-Geddon had Jennix devour the life force of Ben Reilly in an attempt to discover how to use his equipment - what he got was Ben's headful of hideous trauma, which drove him insane. This was the plan all along.
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Less by design, but the Corpsetaker gets burned by this in Ghost Story. She was in the middle of performing a Grand Theft Me, and the victim was fighting back. Then Morty the ectomancer shows up with a horde of wraiths. If the Corpsetaker had taken anyone else, she would have won. But it was her victim's ability to hold onto her that allowed Morty to give her the bum rush to Hell.
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Two examples from the Budokai video game series; in the first Budokai game, there's a What-If scenario where Cell accidentally absorbs Krillin instead of Android 18, leading to a severely weakened Cell being defeated by Yamcha and Tien. In the second Budokai game, Buu's absorption move randomly selects a character to absorb out of Gohan, Gotenks, Vegeta, Cell, Frieza, or Yamcha and Tien together. While the other absorptions make Buu stronger, the last one makes him weaker.
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In the Sabina Kane series a vampire who feeds on a drug addict can end up with the same addiction. Although Sabina considers the occasional pothead a fun snack.
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Star Trek:
Star Trek: The Next Generation: In "I Borg", the Enterprise crew consider using "Hugh", a captured Borg drone, as a Typhoid Mary for a cyberweapon to destroy the Borg Collective. They instead send him back without it, hoping that the sense of individuality he gained from interacting with them will defeat the Borg non-violently. "Descent" reveals that the individuality infected the Borg cube that took him aboard, whereupon the main Borg Collective ejected them from it in self-defense.
Star Trek: Voyager:
The series eventually lampshaded the Kazons' Too Dumb to Live tendencies by having Seven of Nine remark that assimilating them would weaken the Borg Collective. This makes them the only known species the Borg simply refused to assimilate.
In the series finale, "Endgame", Admiral Janeway infects herself with a bioweapon before meeting the Borg Queen. When the Queen assimilates her, it infects that entire collective.
Icheb from "Child's Play" was also intended to be one of these, but it ended up only disabling the ship that assimilated him. The collective immediately severed the ship from the hive mind and declared it not worth assisting.
Species 6339, from Infinite Regress, tried the same thing, and sent 13 of their number to be assimilated so that they could infect the Borg with the pathogen. Just like with Icheb, it didn't spread beyond a single ship.
In Season 3 of Star Trek: Picard copies of both Data's and Lore's minds are put into the postironic brain of an advanced new android. Initially separated by a partition, desperate circumstances force the removal of that partition, leading to a Battle in the Center of the Mind. Lore prevails easily, with Data not even resisting — but because Lore was compelled to steal Data's memories as trophies (just as Data expected) he effectively became Data.
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Kamen Rider:
Kamen Rider Double has an Arc Villain who isn't satisfied with having already won the Superpower Lottery with the Weather Memory, and instead aims to assimilate even more powers into himself through a process that involves using others as incubators. When his Memory is finally broken, he loses control of the other powers he absorbed, which kill him in nightmarish fashion.
Kamen Rider OOO has Kazari theorize that he can take advantage of the Bizarre Alien Biology that he and his fellow homunculi share to absorb their powers for himself by inserting their Core Medals into his own body. Recognizing the possibility of this trope being in play, he has the sense to use Dumb Muscle Gamel as a test subject first. Absorbing a lot of other Cores at once temporarily powers Gamel up, but soon causes him to mutate into a mindless monster, which leads Kazari to take his own assimilation process much more slowly and carefully. At the end of the show, the Big Bad uses this same mechanic to stuff every remaining Core into Uva, the last surviving homunculus, so the resulting monster will destroy the world.
Kamen Rider Drive has this as what happened to turn Mad Doctor Medic into such a monster. She has the powers to heal others by touch, but absorbs their emotions in the process, and healing a large number of villains in rapid succession caused their combined evil to overwhelm her mind. She's cured right at the very end when she heals The Hero and thus absorbs his goodness.
Kamen Rider Ghost has the Big Bad Adel given control of an array of immortal and self-evolving golems when he becomes king, which he learns to merge with into a combat-capable form of his own as part of a plan to assimilate everyone in the world. His abuse of their powers soon causes the golems to become sentient and slip the yoke of his control, at which point they absorb him and resume the plan with themselves in control.
Kamen Rider Ex-Aid Big Bad Kamen Rider Cronus absorbs the personification of the Gamedeus pandemic when his own Time Master powers prove insufficient to win. Merging with Gamedeus gives Cronus even greater powers, but introduces a humiliating weakness, as it means he's now vulnerable to the puny Level 1 forms that haven't been seen since the very beginning of the show, but are designed specifically for dealing with virus/human fusions. Worse yet, the damage from the fight causes Cronus to start losing his original powers as well after the merger breaks apart, allowing the heroes to swiftly finish him off.
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KonoSuba:
Downplayed with Vanir possessing Darkness; while he does manage to control Darkness and make her fight far more effectively than ever before, she can still talk and ruin all of his cool lines. He is also horrified his warning that struggling against his control would cause more pain would convince Darkness to struggle even more.
Sylvia is defeated when she assimilates a willing Kazuma who then brings down her barrier.
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In Tyranny, this can happen if you sacrifice a party member with high Loyalty to The Voices of Nerat. Instead of being subsumed, they can end up becoming the dominant personality and keep their sense of self, leading to a new ending in the epilogue.
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Zigzagged in Lexx episode "The Giga Shadow", where the cleric Yottskry, in an attempt to halt the Divine Shadow's rebirth, is instead possessed by the Divine Shadow and assimilated into the Divine Shadow's ultimate vessel, the Giga Shadow. When the Divine Shadow attempts to be reborn, it is Yottskry who musters the mental strength to stave off the Divine Shadow's attacks against Kai (who is crawling around inside the Giga Shadow) and help direct him to the central brain so he could put the Divine Shadow to rest. Ultimately, Yottskry is overpowered by the Divine Shadow and assimilated completely, and Kai is ejected from the Giga Shadow. All turns out well, however, when Squish, a baby cluster lizard, navigates to and consumes the Giga Shadow's brains, its favorite delicacy.
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The Superman villain Parasite is a power thief who also gains the victim's weaknesses. This means whenever he steals Superman's powerset, Superman can actually beat him by using kryptonite.
Meanwhile, in one time where Superman had to Fight Dracula, he was bitten... only for Dracula to immediately turn to ash, as Superman is a walking solar battery.
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The Flash Sentry Chronicles: This actually happened to King Sombra twice! Albeit once to two different versions of him, but still.
During season 5, in the final Bad Future that Twilight, Spike, and Starlight travel to, flashbacks reveal that the Flash Sentry of that particular timeline never met Twilight or any of his other friends, and after leaving Canterlot he eventually made his way to the North when the Crystal Empire reappeared and encountered Sombra. Sombra tried to possess his body instead of spending a few days rebuilding his own so he could conquer the Crystal Empire faster, but Flash's Sacred Light protected him from Sombra's attempt, and destroyed Sombra instead. However, Sombra's attempt still left an influence on Flash, giving him all of Sombra's dark powers, his memories, and his ambitions, giving this Evil Flash everything he needed to conquer Equestria himself.
In the main timeline, during War of the Lost City after Sombra is revived by Shadow Corrupter, and freed from being Armalum's host, he reveals that when he originally fought Flash and gave him his scar, he secretly implanted a small part of his soul inside it, just in case he died in battle that day, which is exactly what happened. Sombra's soul was originally supposed to corrupt Flash's body once he let enough dark emotions take hold of him, allowing Sombra to hijack his body and use it himself. However, the corruption never happened, because Flash's friends were able to help get him back to normal, allowing him to fight off Sombra's darkness without knowing it. Additionally, the longer Sombra's soul stayed inside Flash, the longer Flash ended up influencing Sombra instead of the other way around, meaning that when Sombra was eventually resurrected another way, he had all of his old memories plus Flash's, and now felt guilty for his prior actions and wanted to atone.
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In the Hyperdrive episode "Harvest", the Brilliant, but Lazy Jeffers is temporarily assimilated by the Red, Shiny Robots of Vortis. After the crew escape and sabotage the robot ship, none of the robots can be bothered to repair it.
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Animorphs: By morphing a Howler, a race of Psychopathic Manchildren with a species-wide Hive Mind (anything one sees, all of them know), Jake manages to implant the memory of his and Cassie's First Kiss. Because of the Howlers' Blue-and-Orange Morality, the concept of love is completely alien to them, and now that they've been exposed to it, they don't want to fight the protagonists. The Elllimist tells him that the next time they're deployed, they'll try this novel tactic, which will ensure that they will never be used as shock troops again.
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Kamen Rider OOO has Kazari theorize that he can take advantage of the Bizarre Alien Biology that he and his fellow homunculi share to absorb their powers for himself by inserting their Core Medals into his own body. Recognizing the possibility of this trope being in play, he has the sense to use Dumb Muscle Gamel as a test subject first. Absorbing a lot of other Cores at once temporarily powers Gamel up, but soon causes him to mutate into a mindless monster, which leads Kazari to take his own assimilation process much more slowly and carefully. At the end of the show, the Big Bad uses this same mechanic to stuff every remaining Core into Uva, the last surviving homunculus, so the resulting monster will destroy the world.
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Cyberpunk: In the aftermath of the Fourth Corporate War, the US government tried to reverse a long decline by nationalizing the weakened MegaCorp Militech. However, the resulting process left a lot of key positions in local, state and federal governments filled with people with stronger ties to Militech than the US. De jure, the US is the senior partner, and no-one outside the top echelons of power knows exactly what the power balance is, but a number of events have raised the nagging suspicion that the "nationalization" left the US a Militech subsidiary in all but name.
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In Dragon Ball Super, both the Commeson and Merged Zamasu suffer from this. When the Commeson assimilates Vegeta to create Copy-Vegeta, Copy-Vegeta inherits the original's strong will and goes rogue. And because Merged Zamasu is the permanent fusion of the immortal Future Zamasu and the mortal Goku Black, his immortality is flawed and his body becomes unstable, leading to his downfall.
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SSSS.GRIDMAN features Anti, a kaiju created to copy all of Gridman's powers as the perfect tool for defeating him. Unfortunately for Anti, Gridman's "powers" include having a strict time limit on how long he can stay in battle, and unfortunately for Anti's creator, Gridman's greatest power is his noble heart, meaning eventually Anti copies that and makes a Heel–Face Turn.
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Becoming a True Invader: During the Final Battle, Zim uses the Employer's ability to absorb technology into his body against him by tricking him into absorbing weapons that have been rigged to explode, severely damaging him. Later on, he's tricked into absorbing GIR, which leaves him unstable and gives the heroes an advantage.
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Demon Lord Dante: The eponymous Sealed Evil in a Can manages to lure protagonist Ryou Utsugi into freeing it, then eats him alive. However, Ryou's latent psychic abilities prove too strong and his mind ends up taking over Dante's body. This is not a clean transfer, as Ryou is left with a lot of Dante's violent impulses, and struggles to remind himself of who he really is. Subverted: Ryou is Dante, who sent his spirit into the future to free himself, and eventually regains his memories.
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Old Kingdom: At the climax of Sabriel, Kerrigor devours Mogget aka Yrael, one of the gods of the setting and absorbs his power. Unfortunately for Kerrigor, this also makes him subject to the magical bindings that made Mogget subordinate to the Abhorsens, giving Sabriel a way to defeat him.
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Magic: The Gathering features a race of highly mutable insects known as "slivers". A hive mind link allows a sliver to share its mutations with any slivers nearby. In game terms, this means that each sliver grants all other slivers on the table (friend and foe) an ability, such as Lifelink, Deathtouch, Flying, etc. These are almost always beneficial, but there are ways a savvy opponent can cause the sliver's mechanics to backfire. The two most visible ways are "Hivestone" (all creatures you control are slivers in addition to their other types), allowing the opponent to gain all the benefits the opposing player's slivers grant to all of their creatures, and "Plague Sliver", which causes all slivers to deal one damage to their controller at the start of every turn (inconsequential if the plague sliver is the only sliver you have, but devastating for an opponent who may have a dozen or more slivers in play). As the flavour text for the latter points out, "A sliver shares everything with its hive - even its afflictions."
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In the God Eater series, the Aragami are organisms made up of a colony of voracious, all-consuming cells that take on the traits and properties of anything they consume, organic or inorganic. This went horribly wrong for the Golden Gboro-Gboro species, which was implied to have feasted on pure metals - they've become so fragile they easily die in under five hits to the weakest of weapons. It's good news for the player though, since they drop lots of different metals you can use for crafting.
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Occurs in a weird way in Rebuild of Evangelion, as Zeruel eats Rei's EVA (with Rei still inside it) to assimilate it and get around the self-destruct mechanism NERV set up in case an angel got to Central Dogma. This turns out to be the last mistake Zeruel makes, not because Rei breaks out herself, but because Shinji tears it into tiny pieces to get her back.
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Death's Head II has a mind built from 106 absorbed personalities. Some of them didn't assimilate so well, though — in Battletide II, the sorcerer Bezial escaped to a new body and left Death's Head infected with a lethal virus, for example.
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Fate/kaleid liner PRISMA☆ILLYA: Expanding on the Fate/stay night example, the second Archer class card (corresponding to Gilgamesh) is an anomaly which carries not only the power of the King of Heroes, but also his Awesome Ego. When Miyu uses the card, she quickly begins taking on Gilgamesh's mannerisms (such as calling her enemies "mongrels"), and is briefly taken over entirely before the card is forcibly ejected. Angelica, the card's previous user, reveals that she was only able to channel Gilgamesh's power safely because her ability to feel emotions had been removed, muting his influence.
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Spider-Man: After Eddie Brock busted out of prison, his symbiote left behind a spawn which bonded with his cellmate, Cletus Kasady. Cletus' psyche seemed to have completely dominated the newborn symbiote's, as he refers to himself as "I" instead of using "We" like most symbiote/host unions do.
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In Robot Chicken, the Borg meet their match in Captain Jake, captain for the Enterprise-D night crew. Assimilating duty-bound officers is one thing, but a frat boy in a uniform causes the entire collective to become obsessed with partying.
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The ultimate Venomverse villains, the Poisons, are able to spawn new Poisons by bonding a superhuman to a symbiote, then infecting them with a larva creature. Unfortunately for them, several characters prove resistant to this: Deadpool and Carnage are too crazy to reliably manipulate, and Jean Grey too strong-willed to fully succumb, leading to the destruction of most of the Hive when Jean steals their power and uses it to kill the Poison Queen.
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Young Justice (2010) has an appearance of Parasite, who is defeated when he steals Miss Martian's powers without realizing they came with a weakness to fire, which the heroes exploit. That's how the Parasite is generally defeated. When he takes on a hero's powers, he takes on their weaknesses — which the hero knows inside and out and the Parasite often doesn't. A little fire/Kryptonite/yellow/expiration of the time limit, and he's back to the Cardboard Prison.
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In Fate/stay night: In the final route, Heaven's Feel, the Holy Grail War is thrown Off the Rails by the appearance of a mysterious entity known only as "the Shadow" with the ability to absorb and corrupt Servants. When it tries this on Gilgamesh, though, Gil is so powerful and "pure" that the Shadow is unable to subsume him, and is almost destroyed itself. It settles for digesting him into raw Mana instead.
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The Hitchhiker's Guide to the Galaxy: In Life, the Universe and Everything, The Krikkiters find Marvin the depressed robot on Sqornshellous Zeta, and capture him, thinking that his massive intellect will be an asset to them. They plug him into their war computer, allowing him to plan their entire military strategy. But any AI that comes in contact with Marvin's mind becomes as depressed as he is (he had previously driven a spaceship and a bridge to suicide), and the Krikkit-bots wind up doing nothing but sulking.
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 The Hitchhiker's Guide to the Galaxy
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Warhammer 40,000:
A background character is Ax'Senaea the Thrice-Possessed, a woman who, as the name suggests, was possessed three times by daemons. But while even throwing off a single daemon is cause enough for celebration, she did so willingly, her Awesome Ego convincing her she could reverse the possession by sheer willpower in order to extend her lifespan and beauty. After summoning and successfully consuming a Keeper of Secrets, a Greater Daemon of Slaanesh, she realized it wasn't enough. So she did it again with an equally powerful daemon. And again with another. She was about to go for a fourth when Slaanesh hirself appeared and elevated her to Daemon Princesshood, allowing her to keep the daemons trapped inside her as punishment for being defeated by a mortal.
Kroot Shapers exist purely to avert this trope. Kroot very much run on You Are Who You Eat rules, as they can store information from consumed prey in their DNA and incorporate it into their own genetics. This can prove dangerous, as Kroot who eat something they shouldn't might find themselves devolving into an animalistic state (such as the Krootox or Kroot Hounds) and can pass on these bad genetics to future generations of Kroot. As such, Kroot Shapers are responsible for tasting new and unfamiliar prey, analyzing its DNA and guiding the Kroot on what prey they should avoid consuming to stop them from heading down an evolutionary dead end or what prey they should seek out to evolve further beneficial attributes.
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Basic Instructions: After learning that his comics were fed into the Midjourney image generation AI, Scott put together an entire comic, "How to Behave When Involved in an Important Current Event," based on the idea that his comics - based on images that are traced from photographs, pasted into position, with the actual humour mostly coming from the dialogue - were bad enough that their inclusion in a Midjourney training data set would either contribute nothing or actively make Midjourney's output worse.
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Boldores And Boomsticks: Lt. Surge, Weiss and Ruby just defeated the body a Geist made for itself from construction equipment, but the Geist survived the finishing blow and goes for the first object it can find... a porta-potty. After a few seconds, it comes back out looking ready to gag before Lt. Surge puts it out its misery.
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In the post-game of Kirby and the Forgotten Land, the soul of Fecto Forgo gets absorbed by Morpho Knight for the latter to reincarnate into its warrior form. Normally this would cause the absorbed soul to be sent to the afterlife, but Forgo manages to evade this fate and use Morpho Knight's power to become the True Final Boss, Chaos Elfilis.
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Morgaine Cycle: Vayne's cousin Roh is invaded (via the gate system) by an ancient personage who has been doing it for centuries. Roh manages to fight him off and retake control by the end of the 3rd novel.
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In The Matrix Revolutions, Agent Smith assimilates The Oracle, which appears to backfire in some way (since she knew he was coming). It backfires because, as she explained to Neo, "We can't see past the choices we don't understand." Smith could see that Neo would die, but not the reason he sacrificed himself. At the end, Neo's assimilation saddles Smith with a direct link back to the machines, allowing them to purge the rogue AI.
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 The Matrix Revolutions
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Doctor Who:
"The Tomb of the Cybermen": Toberman is able to maintain enough self-control in spite of the conversion process to turn on the Cyber-Controller, giving him a chance to pull off a Heroic Sacrifice and save the day.
"Smith and Jones": An alien drinks human blood so the Judoon will think she's human when bio-scanned. The Doctor tricks her into drinking his blood, so she still looks like an alien through the bio-scanner. (A different type than she really is, but it still gets the Judoon to deal with her.)
"Daleks in Manhattan"/"Evolution of the Daleks": In an experiment designed to save the Daleks from extinction, Dalek Sec absorbs human DNA and mutates itself into a human/Dalek hybrid. The new hybrid-Sec finds himself developing human values and emotions, and eventually decides the Dalek's best chance of survival is to free the next generation from their genocidal hatred of non-Dalek life. Naturally, this doesn't sit well with his Dalek comrades, who proceed to execute him in disgust, much to the Doctor's consternation.
"The Next Doctor": The Cybermen attempt to upgrade Miss Hartigan, but she's so strong-willed that she not only survives the process with her mind intact but manages to rewrite the Cybermen's programming.
"Asylum of the Daleks": Oswin Oswald is physically converted into a Dalek, but fights off the associated mental conditioning. It ends up with the Daleks losing all knowledge of the Doctor.
"The Day of the Doctor": The Zygon who takes Osgood's form also acquires her asthma.
"Death in Heaven": Missy's Evil Plan of making all Earth's dead into Cybermen proves ill-advised when this includes Danny Pink (who breaks free and helps the Doctor and Clara) and The Brigadier (who breaks free, saves his daughter from being dropped out of a plane, and shoots Missy).
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In the Forges of Mars trilogy, the robot Galatea steals Linya Tychon’s brain and adds her to its Wetware CPU neuromatrix. This proves a costly mistake, as once Linya has gotten over the horror of being reduced to a Brain in a Jar, she realizes that Galatea cannot parse modern hexamathic code and starts exploiting that vulnerability to sabotage it from within.
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In Shantae and the Seven Sirens, the Empress Siren is able to restore her physical form by consuming some life force from the half-genies Risky Boots delivered to her. By taking the magic from five drops of genie life force, she would have true immortality and become unstoppable. Unfortunately for her, the fifth "half-genie" was actually Rottytops, and from her she took the "life" force of the undead. Her new body was rotting from the inside as soon as it was created. This is also what allows Shantae to ultimately win.
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In a VGA Planets/Star Trek: The Next Generation crossover fanfic Boeuf Borgignon: The Planet of the Steaks the Borg assimilate a planet full of Bovinoids. Since there is such a huge number of Bovinoids, Borgs start adopting their mannerisms. Moo.
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Baccano!: Szilard Quates makes his eternal living devouring the memories and abilities of other immortals who oppose his plan to share immortality with the world (Trust us, it's not as noble a goal as it seems.). However, being an immortal himself, he ends up falling victim to this by Firo Prochainezo once he and a large group of others drink the immortality elixir (believed to be liquor by Isaac and Miria). This helps in not only stopping Szilard's run of taking other immortals' lives, but also gives Firo the knowledge on how to stop Ennis from dying, as Szilard had the ability to mentally control her state of physical health.
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Re:Zero: Once Louis Arneb eats Subaru's memories and finds out about Return by Death, she thinks that's the ideal power to have the most perfect and happiest life since the user can undo any of their mistakes and failures. Wishing to steal Return by Death, Louis creates a copy of herself and uses it to possess Subaru's body. Louis then discovers that she vastly underestimated the critical mental damage and trauma experiencing your own death over and over again causes. After she's out of Subaru's body, Louis doesn't care about having the perfect life anymore; all she can think now is how much she doesn't want to die again.
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Tales from the Mos Eisley Cantina: In "Soup's On: The Pipe Smoker's Tale", space vampire Dannik Jerriko became addicted to "tabac" after feeding on a smoker.
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In Osmos the assimilation of other cells is the goal, but it is governed by the laws of osmosis (or at least some version of it). As such, an attempt to consume a cell even slightly bigger than your own will backfire and result in your cell absorbed.
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In Gold Digger, Dreadwing has been using his Fusion Dance ability to forcibly fuse with people to gain their abilities, while holding their minds down with his own will. When he fuses with a pair of Wererats to steal their inherent luck however, they prove a little too slippery, sneaking behind his metaphorical back and causing him to pickpocket people within reach. He also finds out that he's picked up a wererat's inherent fear/paralysis when meeting the gaze of a Werecheetah. When he finally reaches the wellspring of power he's been seeking, he not only gets the power, but so do those he's fused with, including Benjy, the actual owner of the Fusion ability, who has the power to undo all the fusions as well...
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In The Order of the Stick, Durkon is turned into a vampire, effectively having his soul trapped in his own mind. The negative energy spirit that controls his body is able to absorb his memories at will, allowing it to mimic Durkon. However, it lacks the ability to understand Durkon's feelings. This bites it in the ass when it becomes confused and tormented by an act of utter selflessness performed by Durkon's mother, and upon demanding that Durkon show it all his memories to help process the information, the spirit is overwhelmed and becomes Durkon.
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Ben 10: Omniverse:
In "Showdown Part 2", Malware manages to absorb Ben as Waybig into himself. Inside, Ben has a flashback and finally forgives himself for losing Feedback, resulting in him reobtaining and transforming into Feedback to escape from Malware from the inside. Malware was doubly surprised for Ben escaping and doing it as Feedback, the alien he had destroyed in the past.
Malware's past attempt to absorb the Omnitrix backfired when the angry Ben released the Omnitrix's vast power inside Malware, causing him to explode.
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One episode of South Park has Cartman's super high-tech Trapper Keeper begin assimilating all technology (beginning with a calculator, then a computer, then a lamp, then Cartman). "Trapper Keeper ready to ensorb." Eventually, it goes on a rampage and heads for Cheyenne Mountain to ensorb the NORAD command center there, but on the way it eats Rosie O'Donnell, weakening it enough for Kyle to turn it off.
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Left Beyond: Yahweh must emulate the Omega in order to apply the White Throne Judgement to them, so the Omega initiate a fork bomb, which slows Yahweh down for long enough for the interstellar colonists to escape from it.
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In Bad Machinery's "The Case of the Unwelcome Visitor", an Eldritch Abomination that eats hope makes the (fatal) mistake of consuming the ghost of Todd Baxter, the most miserable rock star in history. (As a bonus, Baxter finally gets to feel happiness, and cross over.)
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The Martians in The War of the Worlds drink human blood, both as a form of sustenance and in an attempt to assimilate certain biological factors that will allow them to adapt to Earth's atmosphere more quickly. It doesn't end well for them.
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During the "Sons of Brainiac" storyline in R.E.B.E.L.S., Brainiac is assimilating the knowledge within the minds of his cloneson Brainiac 2 and his grandson Brainiac 3. Sensing some partitioned information within the former's mind, he greedily takes it in, realizing too late that it's his son's repressed feelings towards being a clone used as a tool but also craving the approval of his "father". Brainiac is left debilitated and in tears over the intensity of such emotions and is forced to retreat.
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When the Red Court took Susan into their midst, it proved to be an interesting setback in Changes, when Harry causes a powerful death spell meant for him to genocide the entire Red Court, by backfiring the spell using Susan as a willing conduit.
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Dragon Ball Z:
While Kid Buu absorbing the Southern Supreme Kai (a skilled, muscular warrior) transformed him into the more powerful "Buff Buu", his absorption of the Grand Supreme Kai (a "Fat Buddha"-like All-Loving Hero) actually made him less dangerous, turning him from a berserk, untiring killing machine into Fat Buu, a cruel but innocent child who eventually pulls a Heel–Face Turn.
When a redeemed Fat Buu witnesses his friends' apparent murder, he spawns an avatar of rage and grief called Evil Buu. After punishing the intruders, Evil Buu then attacks Fat Buu and absorbs him to become Super Buu. However, this comes back to bite him several times, as the good Buu's memories of his friendship with Mr. Satan prevent Super Buu from killing his former friend, and he is convinced to wait for Goten and Trunks to prepare for their fight with him when asked to do so by Mr. Satan's daughter Videl.
When Super Buu ends up getting trashed by Ultimate Gohan, he tricks Goten and Trunks into refusing into Gotenks and then absorbs him to get the power-up to become stronger than Gohan, as well as absorbing Piccolo for his intellect. However, the Fusion Dance time limit of thirty minutes is still in effect, and once it runs out Super Buu loses a good chunk of power and once again becomes weaker than Ultimate Gohan. Luckily for Buu, he had a back-up plan and proceeds to absorb Gohan, powering up even further without the power loss drawback.
After witnessing Super Buu absorb a number of protagonists to gain their power and intelligence, Vegetto tricks Super Buu into absorbing him as well, but raises a barrier at the last second which prevents him from actually merging into Buu's body. Vegetto (now split into Vegeta and Goku) then explores the inside of Buu's body to locate his previously absorbed victims and free them.
Finally inverted when Vegeta discovers Fat Buu inside of Super Buu's body and frees him as well, hoping to weaken or kill his opponent. Instead this purges Super Buu of Kai influence, causing him to revert back into Kid Buu (while the purified Fat Buu becomes a weaker independent being).
Two examples from the Budokai video game series; in the first Budokai game, there's a What-If scenario where Cell accidentally absorbs Krillin instead of Android 18, leading to a severely weakened Cell being defeated by Yamcha and Tien. In the second Budokai game, Buu's absorption move randomly selects a character to absorb out of Gohan, Gotenks, Vegeta, Cell, Frieza, or Yamcha and Tien together. While the other absorptions make Buu stronger, the last one makes him weaker.
Contemplated in the fight against Buu, where Goku wondered if he should fuse with Mr. Satan. He decides it would probably make him weaker, but is desperate enough to try it before Vegeta shows up. The second Budokai game likewise has this fusion option as a playable character.
In Dragon Ball Super, both the Commeson and Merged Zamasu suffer from this. When the Commeson assimilates Vegeta to create Copy-Vegeta, Copy-Vegeta inherits the original's strong will and goes rogue. And because Merged Zamasu is the permanent fusion of the immortal Future Zamasu and the mortal Goku Black, his immortality is flawed and his body becomes unstable, leading to his downfall.
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Star Trek: Voyager:
The series eventually lampshaded the Kazons' Too Dumb to Live tendencies by having Seven of Nine remark that assimilating them would weaken the Borg Collective. This makes them the only known species the Borg simply refused to assimilate.
In the series finale, "Endgame", Admiral Janeway infects herself with a bioweapon before meeting the Borg Queen. When the Queen assimilates her, it infects that entire collective.
Icheb from "Child's Play" was also intended to be one of these, but it ended up only disabling the ship that assimilated him. The collective immediately severed the ship from the hive mind and declared it not worth assisting.
Species 6339, from Infinite Regress, tried the same thing, and sent 13 of their number to be assimilated so that they could infect the Borg with the pathogen. Just like with Icheb, it didn't spread beyond a single ship.
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In one Fantastic Four storyline, an alien tried to download Reed Richards' mind into his ship's computer. His intention was to gain all of his knowledge as an easy - to - read database, but Reed's will and intelligence were so great that he managed to retain his consciousness and take over the ship's computer.
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Housepets!: Keene warns Negabreel that this could happen if he re-absorbs Breel, leading him to try and prove him wrong by absorbing a portion of Breel's guilt, only for the feeling to lay him out flat.
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Kingdom of Loathing had this as the plot of their holiday event one year. When a Borg expy lands in the kingdom and starts assimilating people, they absorb the local Bad Santa "Uncle Crimbo", whose magical power is greatest during the holiday season. As a result, they become the Crimborg. Still a hivemind bent on mass assimilation, but with a festive flair.
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Crisis on Infinite Earths: The Anti-Monitor, having just taken a serious beating from the heroes, tries to regain some of his strength by absorbing his army of shadow demons. The mystics knew he would try this, however, and magically altered the demons to destroy him from within. As a result, the Anti-Monitor becomes greatly weakened after the initial power boost.
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Men in Black: The Series: Alpha, an ex-MiB agent, grafts stolen alien limbs to his human body. When they start falling apart, he seeks out an alien symbiote with a Healing Factor to restore them. When he manages to assimilate not one but two symbiotes, the regeneration works so well that his stolen alien parts start regrowing their own bodies and end up tearing right out of him.
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Star Trek: Destiny reveals that this is why The Borg Collective is evil. They assimilated something they shouldn't have and became slaves to a mindless all-consuming hunger as a result.
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In Hellsing, this is how Alucard is ultimately defeated. During the final battle with Walter, Alucard absorbs the souls of every one of the dead in London after Anderson destroyed his familiars. Unfortunately for him, Schrodinger, who had been created by Millennium for this exact purpose, killed himself and cast himself into the ocean of blood that Alucard was absorbing. Schrodinger's prime trait was an ability to exist as long as he could recognize himself, and once absorbed and integrated into Alucard's three million souls, Schrodinger could recognize himself no longer and disappeared along with Alucard. Alucard was only able to bring himself back by killing each and every one of the three million souls he had absorbed with the exception of Schrodinger, which took him thirty long years.
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YuYu Hakusho: When Sensui Seven member Gourmet eats Elder Toguro to get his powers, Elder Toguro ends up taking over his body later.
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Implied at the end of FLCL. After Naota and Canti are assimilated into the Medica Mechanica device to iron out the planet, they soon break out again.... taking Atomsk with them, then promptly wreck the weapon.
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Journey On: If Shirley is fully corrupted, the Avatar of Darkness will absorb her. If the player has the Holy Sword, Shirley will occasionally stun the Avatar at certain HP thresholds, though she ultimately dies alongside the Avatar. If the player doesn't have the sword, Shirley will break free after Selena guards enough times.
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Kamen Rider Double has an Arc Villain who isn't satisfied with having already won the Superpower Lottery with the Weather Memory, and instead aims to assimilate even more powers into himself through a process that involves using others as incubators. When his Memory is finally broken, he loses control of the other powers he absorbed, which kill him in nightmarish fashion.
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Star Trek: The Next Generation: In "I Borg", the Enterprise crew consider using "Hugh", a captured Borg drone, as a Typhoid Mary for a cyberweapon to destroy the Borg Collective. They instead send him back without it, hoping that the sense of individuality he gained from interacting with them will defeat the Borg non-violently. "Descent" reveals that the individuality infected the Borg cube that took him aboard, whereupon the main Borg Collective ejected them from it in self-defense.
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The following is a list of statements referring to the current page from other pages.

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Index Backfire
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One with the Index
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