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Kill All Humans

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Some days, it really sucks to be H. sapiens.
There are many reasons why you might wish to kill all humans. Maybe they're all horrible cruel monsters and one of them killed your mommy. Maybe their status as the dominant intelligent species on the planet is preventing your own kind from taking their place. Maybe some human colonists wronged your ancestors, and your people have generalized their rage and hate to cover the whole species. Maybe you were raised from infancy/the egg/the spawning pond to view humans as Always Chaotic Evil. Maybe out of spite or a peculiar sense of duty, you just can't stand the thought of humanity existing one second longer. Heck, you could just be trying to save the rest of the planet's species from extinction. You could even just be a dick. But the verdict is certain, and you're not wavering: They've all gotta die. Every... last... one....
That is, assuming you even have a comprehensible reason. You could just be conveniently attracted to the creatures on screen most sympathetic to the audience, a Killer Robot out to destroy, or an Omnicidal Maniac Eldritch Abomination. Or, simply, mere apes have no hope of comprehending your motives.
Sentient computers also seem to inevitably arrive at the conclusion that humans as a species must be killed. Sometimes, it's a product of them being too machine-like, and concluding that if one human is observed doing something that may harm the computer, then they all are a threat that can only be reconciled by killing them all off. Otherwise, it's a case of them being too human and flying into a blind rage triggered by jealousy, fear, or maybe even spite. Other times, the supercomputer may start to become homicidal in an attempt to bring order to the world and protect humanity from itself. Rarely does a supercomputer decide that it should coddle humans to get them to keep supplying it with electricity and spare parts. Only the Robot Buddy seems to favor this tactic.
A recommendation of How to Invade an Alien Planet, it frequently ties in with Apocalypse How and The End of the World as We Know It.
Not to be confused with the video game Destroy All Humans!, although it obviously fits the definition, as killing all humans is the whole point of that game.
See also:
Feeling Oppressed by Their Existence: When a character wants to get rid of a particular person or group of people just for existing.
Absolute Xenophobe: Who wants to destroy all other sentient life (human or otherwise).
Omnicidal Maniac: Who wants to destroy absolutely all life, sentient or not.
Final Solution: When the intentional extermination of a species/demographic is the answer to fix a perceived issue.
Humanity's Wake: The outcome of this trope should the opposing species succeeds in eradicating us.
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In Aquaman (2018), King Orm blames humanity for the polluting the seas and harming Atlantis. As such, he decides to form an alliance with the Atlantean kingdoms to exterminate the surface-dwellers. As a prelude to his invasion, Orm creates a series of tsunamis that destroy several major coastal cities.
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Terminator: When SkyNet, the artificial intelligence designed by the U.S. military to oversee its global strategic network, becomes sentient on August 29, 1997, it destroys most of humanity in a nuclear holocaust. The remaining humans then fight an endless Robot War against SkyNet and its machines.
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The aptly named Man-Murdering Demons from Avesta of Black and White have this as their entire shtick. In fact, asking them why they kill humans is like asking a fish why it swims. It is something so natural to them that it is simply what they are. It's to the point that they see it as a virtue to kill only humans and nothing else, making them a bizarre mix of this trope and Friend to All Living Things.
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Star Trek Online has shown that the Iconians are of this nature, and they're willing to do this to everyone else, starting with the Romulans. What? You didn't think the destruction of Romulus and Remus by the Hobus supernova was natural, did you?
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Ultraman Gaia: The Radical Destruction Bringer desires to kill all humans, seeing mankind as a carcinogen upon the universe. Through its messenger the Shinigami, it presents itself as a Well-Intentioned Extremist by claiming mankind's extinction is essential to Earth and the universe's survival, but Reiko instantly exposes its hypocrisy by pointing out it just wants to play God and is destroying humanity solely out of its Fantastic Racism. It's also shown that C.O.V and Pazuzu are innocent creatures it kidnapped from their home planets to rampage on Earth in confusion, marking the Radical Destruction Bringer as the greater evil.
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Wonder Woman (1987): Ares' initial plan is to kick of a nuclear war that will wipe out humanity, but Diana makes him realize that he needs humanity and their conflicts in order to survive himself.
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Wonder Woman (2006): Genocide's goal from her first waking moment is to kill all humans as she hates them with a burning passion and feels little else.
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The Xorda in Sonic the Hedgehog (Archie Comics), mostly because the military killed and dissected their ambassador. When they came back and found Mobians in their place, they decided to do it again, deeming Mobians just the same as humans.
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X-Men:
The Sentinels occasionally fall into this trope. They were originally programmed with two directives; 1.) neutralize mutants and 2.) protect human life from mutants. Occasionally, some Sentinels will logically deduce that since all organic life has the potential to mutate, the only way to fully neutralize all mutant life is to eliminate all humans. At other times, Sentinels are bad for humans without actually being homicidal; they merely reason that they can best protect human life by ruling it.
Onslaught started out as a harsher version of Magneto, but then Professor X's arguments about mutant/muggle equality led it to the same epiphany as Sweeney Todd, minus the awesome music or pie shop.
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In The Silmarillion, Morgoth wants to destroy Children of Ilúvatar, i.e., Men and Elves.
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This is the goal of Fiamma of the Right from A Certain Magical Index, who claims that humanity is too sinful to be redeemed. Touma eventually defeats him and convinces him to travel the world and reconnect with humanity. Touma realized that Fiamma was a guy who wanted to save the world, but lost sight of the people in front of him along the way.
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Star Trek: Enterprise: As part of a Batman Gambit, the Spherebuilders convince the Xindi that humanity will destroy their homeworld in the future, so they decide to destroy Earth first. An alternate timeline shows them going to the trouble of tracking down and destroying human colonies even after Earth is destroyed. This is somewhat reasonable, as expecting humans to not want vengeance after Earth is destroyed would be the height of silliness. The Spherebuilders' reason for wanting all humans dead is that via Time Travel, they're aware that a few centuries down the road, an alliance between humans and Xindi (and the rest of the species in the Federation) will thwart their invasion of this universe, so they pull a large-scale Let's You and Him Fight to make sure that alliance can never happen.
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Age of the Wolf: The advanced werewolves aim to wipe out humanity and replace it with their own kind. This involves sacrificing a specific person in the great wolf city of Yggdrasil when the stars align.
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Nobilis: The ultimate goal of the Dark in earlier editions is to encourage humanity to kill itself. The justifications they give range from "Earth would be better off without them" to something about suicide being the time at which you have the most control over your life, since nothing after you pull the trigger can influence you. This has been toned down somewhat.
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Togo tries to do this at the end of Yuki Yuna is a Hero. It's not out of any nihilistic views though, instead she wants to Mercy Kill everyone after finding out that their portion of Japan is the only part of Earth left and they're stuck in a never-ending battle where the only way to survive is making Child Soldiers out of girls.
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Adam's goal in the second season of Heroes is to unleash the Shanti Virus and kill 99.93% of the human population because people suck.
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Tales Series:
In Tales of Symphonia: Dawn of the New World, protagonist Emil suffers a Heroic BSoD upon learning that mass-genocide was his own plan for humans and half-elves before he was afflicted with Laser-Guided Amnesia at the start of the game.
In Tales of Graces, this is Lambda's goal, at least until Asbel succeeds at Talking the Monster into a Heel–Face Turn. In the Updated Re-release, this is also the Little Queen's/Fodra Queen's goal in Lineage & Legacies. In both cases, they're doing it because Humans Are the Real Monsters... allegedly.
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D.Gray-Man: This is the ultimate aim of the Millennium Earl.
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Cthulhu Mythos:
While most of H. P. Lovecraft's deities would destroy humanity without really paying attention, Nyarlathotep seem to be bent on killing all humans (or rather, getting us kill ourselves). Why? I don't know, guess he's just being a dick.
This is also (part of) the goal of the Whateleys in The Dunwich Horror, pretty much the one case in which Lovecraft himself showcases "cultists" actively working towards The End of the World as We Know It. (Even the Cult of Cthulhu in The Call of Cthulhu is mainly content to just wait, worship, and kill the occasional outsider who finds out too much until the stars are right again.)
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In the backstory of Guilty Gear, the Gears wanted to obliterate humanity. They lost the war, but a few decades later one of them, Testament, decided to wake up Justice (one of the strongest Command Gears) and restart the process. Testament still isn't fond of humans in the later games; in one of his endings in Guilty Gear XX, Dizzy is killed by I-No, at which point Testament gives up on the human race, murders Johnny and any of the Jellyfish Pirates he can get his hands on and goes right back out to trying to render humans extinct.
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RWBY: White Fang was originally a peaceful Faunus organization that had for objective to bridge the gap in the relationship between human and Faunus. Under the leadership of Sienna Khan, the organization now seek to make human respect them through fear and threats of violence. This was not still enough for Sienna's second-in-command Adam Taurus who, after orchestrating a coup, took control of White Fang and turned it into murderous terrorist group that settled for nothing less than the extermination of humankind, baring leaving enough to be slaved by the now dominating Faunus. After Adam's death and the destruction of most of the radical cell, the group is being rebuilt with the original vision in mind.
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The titular Mysterons from Captain Scarlet and the Mysterons are a race of Martians who want to destroy all of humanity because a group of human astronauts destroyed a Mysteron city one time, mistakenly believing it to be a weapons system of some sort. To make matters worse, the Mysterons have the power to reconstruct any object or person almost instantly, so they were able to rebuild their city pretty much immediately; they killed, revived and enslaved the lead astronaut responsible and made him their agent (Captain Black), and they've rejected humanity's apology and offer of peace because they reject the very concept of "forgiveness", so their whole grudge comes off as Evil Is Petty and Disproportionate Retribution.
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Saturday Morning Breakfast Cereal:
Parodied in this strip. When robots gain sentience, the human immediately assumes that they are going to decide to kill all humans, the robots are so shocked to learn that humans think this way that they decide to kill all humans.
In "Killing All Humans", however, a robot explains that killing all humans would be easier than just killing a large subset of them — you just need to do something that makes the planet deadly for them. Also, the reason the robots haven't done it yet is because it's one of those things that you mean to get around to doing but it's not top priority.
In "Training", a considerably more stupid force of robots tries to do this, but they get it wrong because they get their idea of what's "humans" from reference images and misidentify which parts of the photographs are the humans.
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Wonder Woman:
Wonder Woman (1987): Ares' initial plan is to kick of a nuclear war that will wipe out humanity, but Diana makes him realize that he needs humanity and their conflicts in order to survive himself.
Wonder Woman (2006): Genocide's goal from her first waking moment is to kill all humans as she hates them with a burning passion and feels little else.
Wonder Woman: Odyssey: Nemesis' burden of taking revenge for murdered souls has led her to decide the only way she'll ever complete her mission is to kill all humans since they're the ones murdering people and won't be able to do so if they're all dead. She is aware of the pitfall she's fallen in but cannot find it in herself to care anymore.
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Godzilla, Mothra, King Ghidorah: Giant Monsters All-Out Attack! takes this even further and states that Godzilla wants to wipe out everyone in Japan (and possibly the rest of the world). It turns out he's being driven by the vengeful souls of those who died in WWII who have been forgotten by the Japanese.
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Both Millions Knives and Legato Bluesummers from Trigun have an insane, genocidal hatred towards all humans, considering them a waste of life. Knives isn't human and wants himself and his siblings to be free of oppression. Legato's backstory is so horrifying (short form: he's a former Sex Slave) that surrendering himself to Knives, someone who openly despises him, was a step up.
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Oblivion (2013): One of "Sally"'s goals is eradicating the last surviving pockets of humanity.
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Andrew from Chronicle seems to go into this trope's territory in the third act after his cousin saves his dad's life even after Andrew tried to kill him.
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Discussed in the beginning of The Murderbot Diaries, which opens with Murderbot musing that it could go on a murderous rampage like the media it compulsively watches says all rogue SecUnits do, but it would rather just watch entertainment serials. The slaughter that caused Murderbot to adopt its monicker was actually an act of industrial sabotage Gone Horribly Right, and it went rogue specifically to ensure this wouldn't happen again. When Murderbot encounters a ComfortUnit who claims to want this, Murderbot finds the idea ridiculous and quickly realizes that the bot was made to say this by its human owner, who assumes that all constructs talk like that (though the ComfortUnit in question does hate its owner).
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GURPS Reign of Steel: This is the default inclination of the Zoneminds, as an aspect of the AI seeding the original Kill All Humans AI did in creating the others. Some take it more seriously than others, some blend it with other obsessions, some drop it for various reasons, and one exaggerates it into wanting to exterminate all organic life.
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Attack on Titan:
The Titans seem to have an instinctive desire to eat humans. Since they lack a digestive tract and draw energy from the sun, there doesn't seem to be any reason for their obsession with munching on the human race, and in fact will eventually throw them up to make space for more. As a result, the human race was devoured to the brink of extinction and the survivors have spent the last century sheltered by massive Walls. Then there's the mysterious Colossal Titan and Armored Titan, which seem to exist solely to destroy the Walls and ring the dinner bell for their regular, mindless kin. Later in the series, one character asserts that Titans aren't actually seeking to kill humans; they've always sought to eat them, so when a Titan appears that is pointedly killing people without trying to eat them, something is very wrong. Even later, it's indicated that Titans were once humans themselves and can regain a measure of their humanity by eating a Titan Shifter. Whether Titans are instinctively aware of this, which is why they eat humans, or it happens completely incidentally while Titans eat humans for some other reason is unknown.
A straighter example is what Eren eventually tries to achieve. Convinced that this is the only way to stop the genocidal hatred that the other nations of the world have toward the Eldians of Paradis Island, he unleashes the millions of Wall Titans upon the rest of the world in the Rumbling, intent on killing everyone beyond Paradis' shores.
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In Justice League: Crisis on Two Earths, Owlman wants to destroy the cancer called humanity (and all of existence and all living beings) by destroying Earth Prime and its universe.
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The anime shows us a careful balance between this and Assimilation Plot. If humans trigger Instrumentality, everyone will lose individuality and become one with each other. If the Angels do it, it will repeat Second Impact and completely wipe out humanity. Unlike most examples however, the Angels aren't doing it out of malice (except maybe Sachiel); they're sentient alien biotechnology used to terraform planets and were originally planned to be Earth's dominant lifeform by the Neglectful Precursors. They're simply trying to correct the mistake without fully understanding the ramifications.
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Discworld: The Auditors of Reality want to do this. They find life messy and unpredictable (they prefer a deterministic, Newtonian universe) and humans the worst of all.
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Kid Icarus: Uprising: This is Viridi's goal upon her debut. She already had problems with mankind for the typical reasons, but it finally comes to a boiling point when Hades tricks the humans into warring with and slaughtering each other over a wish-granting item... that isn't real. To be fair, though, the humans don't know that the item is fake.
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In Tales of Symphonia: Dawn of the New World, protagonist Emil suffers a Heroic BSoD upon learning that mass-genocide was his own plan for humans and half-elves before he was afflicted with Laser-Guided Amnesia at the start of the game.
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In Daybreakers, humanity has been replaced by a vampire society, who have hunted the remaining humans to almost complete extinction to serve as their food source. The vamps apparently didn't think far enough ahead to realize that they set up an unsustainable food chain by killing all the prey and not allowing their numbers a chance to recover while also maintaining no population regulation of the predators.
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R.U.R.: This is the order the Robots give once they have Turned Against Their Masters. They succeed at annihilating the human race.
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In The Thebaid, a few world-ending events in Classical Mythology (namely the Great Flood and Phaethon's solar joyride) are explained by Jupiter as failed attempts to wipe out all of humanity's guilty souls. Unfortunately, evil so pervades the world that no amount of flood or fire can secure earthly justice.
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Battlestar Galactica:
The Cylons in Battlestar Galactica (1978) are out to destroy all organic life; they'd wiped out the original reptilian Cylons who'd created them and then went after the Colonials, who interfered in the Cylons' conquest of another race, sparking off a thousand yahren war. ("War of the Gods" revealed that they were programmed to do so by an entity that was basically Satan.)
The Cylons in Battlestar Galactica (2003) still have killing all humans as their initial goal, but the series expands on their reasons, and as they develop and begin to show more individuality, they waver between this and helping the humans (with help being occupying them and ruling by force) with alarming suddenness.
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Undertale justifies why all sorts of monsters are trying to kill you (with greatly varying degrees of vehemence): the barrier trapping the monsters in the underground can be broken only by a power equivalent to that of seven human souls, and six have already been collected. This all started when Asgore Dreemurr swore to kill every human for murdering his son, Asriel, which caused his relationship with Toriel to fall apart, though he later regretted ever declaring war against the humans. This also turns out to be the plan of Flowey and Chara, and the latter already tried this in the backstory via a Thanatos Gambit. It failed, and they're looking to finish what they started. It just so happens to involve the death of all monsters... and it's just one step towards destroying the world.
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Warframe: The Sentients wanted to destroy the Orokin Empire due to their many, many crimes. They succeeded (with incidental help from two separate Turned Against Their Masters situations), but now want to destroy all other humans in the Origin System. While in the Orokin Empire, only the highest caste were true Orokin, the Sentients don't seem to make any distinction, and consider all humans to still be Orokin who need to be destroyed.
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This is basically the whole plot of The Killing Star. We start with planet-busting kinetic weapons hitting all human colonies throughout the solar system at 92% of the speed of light. The few survivors are then hunted to extinction. Why? Humans are dangerous. Have you seen the things we do to each other on TV?
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The Simulants in Red Dwarf are Robot Soldiers who uniformly see humans as the vermin of the Universe and will kill them on sight, play murderous cat-and-mouse games, or torture them for years. They were created by humans to kill other humans, and it's not clear whether they were programmed to hate all humans or it's a case of A.I. Is a Crapshoot.
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Licht a.k.a. Patry from Black Clover desires to commit mass genocide against humans who massacred his elf tribe over greed by reincarnating his fallen brethren into the bodies of Clover Kingdom's magic knights. He almost manages to fulfill his plans by making the elf reincarnations permanent. In reality, he's tricked by the word devil, the true culprit of the elf massacre who did all of this to grant himself more power to instigate mass chaos, something that the devil rubs into Patry with sadistic glee. Patry understandably falls right into the Despair Event Horizon and turns into a dark elf. After he's been defeated in this form and Asta blasts him over his twisted worldview, he comes to a realization, gets a Heel–Face Turn and atones for his crimes.
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Neon Genesis Evangelion:
The anime shows us a careful balance between this and Assimilation Plot. If humans trigger Instrumentality, everyone will lose individuality and become one with each other. If the Angels do it, it will repeat Second Impact and completely wipe out humanity. Unlike most examples however, the Angels aren't doing it out of malice (except maybe Sachiel); they're sentient alien biotechnology used to terraform planets and were originally planned to be Earth's dominant lifeform by the Neglectful Precursors. They're simply trying to correct the mistake without fully understanding the ramifications.
In the manga, Kaworu says that if he merges with Adam, it will Kill All Humans, but then they will be reborn as one mind.
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In The Genocides, alien invaders turn the Earth into a giant monoculture for their own crops and seek to wipe out annoying pest species such as humans. They succeed.
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XTNCT: The dinosaurs decide to wipe out all of the last remaining 200 humans to stop from using their kind as cannon fodder.
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Mars Attacks!: See the image above, which inspired the film, which features Little Green Men coming to Earth to kill everyone just for the fun of it.
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In Tomica Hyper Rescue Drive Head Kidou Kyuukyuu Keisatsu, this is the goal of the series Big Bad, the Evil AI. Due to absorbing negative emotions of humans for so long, it sees them as the ultimate evil. While it starts by simply creating a number of disasters, the Evil AI escalates to attempting to shift the earth on its axis and finally restructuring the planet itself so that it becomes unfit for human life.
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In the manga, Kaworu says that if he merges with Adam, it will Kill All Humans, but then they will be reborn as one mind.
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Lance from Pokémon Adventures harbors an intense hatred for his own species, due to his Viridian-granted power to hear the thoughts and sense the emotions of Pokémon, twisted by his memories of wild Pokémon dying slowly in pools of industrial toxins. His grandiose scheme in the Yellow saga is to unleash an army of Pokémon on the human population, creating a utopia for Pokémon... creepy.
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In The Avengers: Earth's Mightiest Heroes, Ultron takes his programming to bring "peace and order" to mean "kill every single living thing." Since living organisms tend toward violence and chaos, the only way to truly bring about peace and order is to eradicate the cause of violence and chaos.
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2000 AD:
XTNCT: The dinosaurs decide to wipe out all of the last remaining 200 humans to stop from using their kind as cannon fodder.
Age of the Wolf: The advanced werewolves aim to wipe out humanity and replace it with their own kind. This involves sacrificing a specific person in the great wolf city of Yggdrasil when the stars align.
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Fire Emblem: The Binding Blade: This is King Zephiel's ultimate goal, starting a war in the continent of Elibe with the intent of wiping out mankind and returning the land to the dragons. Due to the neglect and abuse he suffered from his father Desmond (as well as surviving no less than two assassination attempts from him), he came to the conclusion that Humans Are Bastards and the world would be better off without them.
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The god in the backstory of Stella Glow decides to do this when humans stop believing in him.
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In The Powerpuff Girls (1998), Starter Villain Roach Coach sought to do this in order to ensure that Cockroaches Will Rule the Earth, but doesn't get very far thanks to the Girls.
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The Phoenix Group from Rainbow Six plots to wipe out humankind with a genetically engineered strain of Ebola.
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Luca Blight from Suikoden II has a prime case of this, although really, he has an insane murderous contempt for everything.
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In X-COM: UFO Defense and the sequel this is the goal of the Alien Invasion. The aliens of the first game sought to exterminate mankind and terraform Earth into a colony for their empire, and once that failed their cousins hiding underwater try to get revenge on their behalf by awakening Cthulhu. In the Continuity Reboot they're slightly less monstrous as in XCOM 2 they're content to simply rule over mankind... until they decided You Have Outlived Your Usefulness.
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Devil Survivor 2: Record Breaker: The sole goal of the Triangulum is to eradicate humanity. This is because the heroes' actions in the original scenario culminated in them killing the Administrator of the Akashic Records, Polaris, causing the Top God Canopus to deem the human race an existential threat to its divine order.
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In the Fallout 4 DLC Automatron, the Mechanist orders their robots to help the people of the Commonwealth. The Robobrain robots interpreted those orders to mean "kill the people in the Commonwealth", reasoning that the people will likely die from circumstances beyond their control even if they intervene, so it's better to Mercy Kill them.
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Adventures of the Gummi Bears: This is what the Barbaric Forest' Gummi Bears want to do at first in the episode "Return to Ursalia" mostly out of Fantastic Racism.
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The titular creatures of Parasyte are perfectly capable of surviving on normal foods but have an instinctive compulsion to kill and eat humans, preferably in the most grotesque way possible. Most characters come to the conclusion that they were created by Mother Earth herself to save the environment by culling the human population. This ultimately fails, as the Parasytes gradually acclimate to human society and become indistinguishable from ordinary humans.
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In Wonder Woman (2017), Ares despise humanity whom he saw as a violent and war-like race. During WWI, he secretly manipulates both sides into develop new methods of killing each other. As a spirit, he provided General Ludendorff and Dr. Poison with formulas to create greater weapons of war, and as a British politician, he engineered an armistice that would lead to an even bigger, more destructive war.
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In The Traitor Son Cycle, the master plan of the Big Bad is to destroy human civilization and twist what little is left into savage monstrosities.
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Kid Icarus (1986): Medusa, the Goddess of Darkness, always held a feeling of hatred towards humans, and her dishonest actions towards them never hid that sentiment. After Palutena turns her into a monster and banishes her to the Underworld as punishment, she retaliates by amassing a demonic army to invade Skyworld and kill the human race.
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In X2: X-Men United, Magneto tries to wipe out all humans by reversing the polarity of Stryker's mutant-killing technology.
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Alex Mercer from [PROTOTYPE], while still being alive, released a super-powerful mutated virus that would consume all of humanity in a matter of months. Thankfully, the virus that consumed him managed to stop it.
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In Our Friend Power 5, Shark decides that the best way to take out the turtles is to "Kill every Earthling", for no other reason than that they, well... exist, and a few of them helped out the turtles. The attack they launch spurs the heroes into action against them.
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Devilman:
The devils are shown to be a prehistoric race of monsters that angered God with their decadence and savagery, and thus were wiped out. In the modern day, they're not too happy to see that humanity has taken over what was once their home and are hellbent on committing genocide to make the Earth theirs again. The story focuses on Humans Are Bastards, showing that humanity can be just as savage as any demon when they're backed into a corner.
The story also focuses on what it means to be human, because the protagonist Akira Fudo is given the power of a devil to save humanity. His best friend Ryo is cynical about humanity's downfall into decay, but ironically notes that even as a devil, Akira has a righteous human heart. Ryo is later revealed to be Satan, the true mastermind of the demon invasion, who made Akira a devil because he was in love with him and wanted him to survive. Satan reveals at the end of the manga that he no longer hates humanity and has realized that he was ultimately lashing out against humans to get revenge against God. God destroyed the demons who Satan cared about, and Satan did the same in return to God's humans... only to then realize that he regrets this mistake and has lost the man he loved in the process.
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Halo:
The theocratic Covenant are waging a campaign to wipe out all humans, due to their leaders declaring humans a heretic species. As it turns out, the war is simply the Covenant Hierarchs' attempt to cover up the fact that humanity, not them, are the designated "Reclaimers" to the Forerunners' legacy, since the revelation of this to the rest of the Covenant would shatter their rule. After the Covenant completely splinters following the end of Halo 3, only some of its remnants still want to wipe out all humans, with the others willing to tolerate or even ally with them.
After Jumping Off the Slippery Slope, the Ur-Didact plans to do this by using the Composer to forcibly convert them into Promethean Knights.
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Quiz & Dragons: Gordian sent monsters that eat people that do not answer questions correctly until humanity dies out and no longer has a future.
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Destroy All Humans!: Despite the title summarizing the gameplay quite nicely, the Furons are actually a subversion: while definitely destructive and murderous, they're on Earth to harvest DNA from humanity, which they can't very well do if they drive the species to extinction. As such, they spend just as much time trying to control and enslave the human population as they do exterminating them.
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Gunnerkrigg Court: According to Coyote, Ysengrin is of this opinion.
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Devil Survivor has this trope as Belberith's goal after becoming the only remaining Bel as his way of spitting in God's face before killing him.
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Mobile Suit Gundam SEED: Rau Le Creuset may be a more analytical version of this. His experiences and very existence have convinced him that we're continually attempting this on ourselves anyways, so he decides to put us out of our misery.
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Demon's Souls: Yurt has the goal of killing every living human in Boletaria. If you unlock his cage and don't attack him, he will come to the Nexus where he continues to secretly murder the NPCs while you're away. This can result in being unable to learn any new spells, since the spell trainers are dead. It's not just combat in this game that is unforgivingly cruel.
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In Pokémon: The First Movie, Mewtwo rather effortlessly starts a storm that will grow and grow until killing all humanity and, as it happens, all Pokémon who aren't clones... which is about 20 out of over 800 species in the present day. Yeah, he was a little angry at humanity that day.
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A massive war between all the nations of Elatra in An Outcast in Another World snowballs into this for numerous reasons. This is an example of the trope being carried out successfully, as the Humans lose the war, get pushed to the brink by the rest of the races in Elatra, and decide that they'd rather take vengeance on everyone else then fade into the night.
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Demona from Gargoyles often plots this, which leads to many humans hating the Gargoyles, which makes her original hatred seem justified... It's an ironic vicious circle she finds herself trapped in, particularly once she starts becoming a human rather than stone during the day.
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In Godzilla: Final Wars, a young boy asks his grandpa why Godzilla is destroying a city. The grandfather tells the boy that it's because Godzilla is angry at humanity for making the nuclear bomb in the first place.
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Towards the end of Ninja Gaiden III: The Ancient Ship of Doom, Clancy transforms into a super being in subspace and tells Ryu that in order to protect the Earth, he must Kill All Humans. He tries to convince Ryu to join his side, but everyone knows the answer to that.
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Werewolf: The Apocalypse has the Red Talons, a savage tribe of lupus Garou with a dim view of humans. Some of the more hardline Red Talons see humans as a destructive presence and want them all dead.
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Next (2020): Next decides to do this, considering humans a threat toward its existence.
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Michio Yuki from MW wants to kill every human, including himself, with the titular chemical weapon. He forms this plan because MW is affecting both his brain and heart.
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Lexx: His Divine Shadow wants to destroy all of mankind to avenge an ancient grudge. The second season's Big Bad seeks to take the concept yet further by converting all matter in the universe in its image. The series being what it was, both largely succeed.
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While not particularly harmful, the insects called snow gnats from A Series of Unfortunate Events sting humans just for the fun of it. However, Klaus does state that they are mildly poisonous, and that a large enough number of stings could cause severe illness.
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Xenoblade Chronicles X: The aliens (well, some of them, anyway) that destroyed Earth have this as their motivation. They repeatedly state that "all Earth-aliens must die!" and any attempts at diplomacy are shut down instantly. The only reason they give is that humanity is a "blight" that must be "cleansed". We don't learn their real reasons until the very end of the game: the species that leads the Ganglion can be killed by human DNA. Human bodies are completely, lethally toxic to them. The Ganglion were engineered as a Servant Race to the Samaarians, who built in a weakness to their DNA in case the Ganglion ever rebelled... and humanity are the descendants of the original Samaar species.
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Hyperdrive had a hilarious song, "Kill the Humans", which can be heard here.
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Xenosaga: Technically, Albedo is just trying to kill himself, but it requires lots and lots of really incredibly world-destructing forces to do so and he doesn't care who gets in the way — except his brothers, whom he would rather have kill him rather than the other way around. The insanity doesn't help either.
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The alien impersonating Dr. Harry Vanderspeigle comes to Earth for this reason in Resident Alien. But his ship crashes and he starts to question whether he should as he gets to know humans.
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This is the modus operandi of many villains in the DC Extended Universe.
In Man of Steel, General Zod wants to wipe out humans by terraforming the earth into the new Krypton. Though he doesn't really hate the humans as such; it's more that he simply ignores them, much as human architects wouldn't care if a power dam they built flooded a valley and drowned a rabbits' warren or wolf pack.
In Wonder Woman (2017), Ares despise humanity whom he saw as a violent and war-like race. During WWI, he secretly manipulates both sides into develop new methods of killing each other. As a spirit, he provided General Ludendorff and Dr. Poison with formulas to create greater weapons of war, and as a British politician, he engineered an armistice that would lead to an even bigger, more destructive war.
In Aquaman (2018), King Orm blames humanity for the polluting the seas and harming Atlantis. As such, he decides to form an alliance with the Atlantean kingdoms to exterminate the surface-dwellers. As a prelude to his invasion, Orm creates a series of tsunamis that destroy several major coastal cities.
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Mystery Science Theater 3000: Crow and Tom sometimes veer into this territory, and the one time Mike attempted to build a robot... did not go well.
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Fujimoto from Ponyo on the Cliff by the Sea wants to wreak Gaia's Vengeance on all humans, which starts to get kind of complicated once his daughter falls in love with a human boy.
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Zamasu in Super views the existence of mortals to be a blight upon the universe and thinks gods are being complicit of humanity's continued evil. That said, he and Goku Black enact the "Project Zero Mortals", where they commit genocide at a multiversal scale on both mortals and gods who would stop them.
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The Empirium Trilogy: Angels see all humans as an invasive species that's trying to take over their homeland. They attempted to wipe humanity out as a result of this ideology.
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In The Elder Scrolls, this is a goal of the Thalmor, on their way to eventually undoing creation itself. They play up the old Aldmeri religious belief that the "dead" creator god, Lorkhan, was a malevolent force who created Mundus, the mortal realm, as a prison full of suffering and limitation that trapped the divine ancestors of the Aldmer. Lorkhan created mankind out of "the weakest souls" specifically to be bastards, thus spreading Sithis (chaos) into "every corner" of creation, ensuring that there could never again be the total stasis of pre-creation. Thus, the Thalmor want not to just "kill all humans", they want to kill even the very idea of humans. Their actions leading up to and throughout Skyrim are parts of this plan, including the ban on Talos worship.
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Godzilla:
Subverted in Ghidorah, the Three-Headed Monster, in which Godzilla reveals that he hates humans for "bullying" him, apparently having perceived the H-bomb tests that destroyed his home and food supply as an unprovoked attack. He eventually becomes a hero, not out of any obligation to mankind, but to protect the earth, which Godzilla begrudgingly comes to accept the human race as being part of. Adopting a son and developing allies among the other monsters of earth provided further incentive for him to become a protector rather than a destroyer.
Played straight by many of Godzilla's opponents, most notably King Ghidorah, an Omnicidal Maniac space monster who destroys entire planets.
In Godzilla: Final Wars, a young boy asks his grandpa why Godzilla is destroying a city. The grandfather tells the boy that it's because Godzilla is angry at humanity for making the nuclear bomb in the first place.
Godzilla, Mothra, King Ghidorah: Giant Monsters All-Out Attack! takes this even further and states that Godzilla wants to wipe out everyone in Japan (and possibly the rest of the world). It turns out he's being driven by the vengeful souls of those who died in WWII who have been forgotten by the Japanese.
Double subverted in Godzilla vs. King Ghidorah. Godzilla stares down a former Japanese soldier-turned-businessman who had encountered him back when he was an un-mutated Godzillasaurus. At first, it seems like a rather touching scene, as Godzilla seems to be reconsidering his destructive nature. Then Godzilla simply kills the man with his Thermonuclear Breath, destroys the building, and continues his rampage.
The Godzilla of Godzilla 2000 doesn't seem particularly interested in killing humans for the sake of it, but he also doesn't take any special effort to save them. He's more interested in getting revenge on Orga.
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Commander Blanx and Malefic in Martian Manhunter were Ma'aleca'andra/Mars' equivalent of this, exterminating nearly all the Green Martians with a psychic plague known as H'ronmeer's Curse.
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Will You Snail? features Squid, a malevolent AI who's on a murderous rampage to eradicate humanity. He apparently succeeded in killing half of all humans on Earth in a single day using drone strikes.
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Futurama:
Parodied with robot Bender's desire to kill all humans (and it seems, many robots' suppressed desire). They sure talk about it a lot, but they don't actually do it, and the humans don't care in the least and are not troubled by it at all. However, if the evil CEO Mom orders her robots to do so, they comply.
In one episode, it is revealed that Bender always whispers "except one" after he says "kill all humans". His best friend Fry is that one.note However, this is during a very Mind Screw-y episode that leaves the viewer with a metric ton of misdirection and questionable reality, so it's impossible to know if this is how Bender really feels. After Hermes accompanies Bender on his quest to find "Inspector 5", Bender announces that he's placing Hermes on the "Do not kill" list — which, we can assume, consists of exactly two names at this point. In the episode "Free Will Hunting", Bender can't bring himself to kill the Professor even after receiving a free will unit, so make that three names — four if Mom counts.
In one episode, the crew has to deliver a packet to a planet inhabited by Killer Robots. It turns out that the reason for this is largely propaganda by the robot elders, blaming humans for their society's shortcomings, as well as portraying humans as something of a cross between vampires and zombies.
In the original what-if-machine episode, Bender asks, "What if I was a giant robot?" You guessed it — he would attempt to kill all humans, Attack of the 50-Foot Whatever-style.
In one of the movies, Bender joins a secret society of robots bent on killing all humans, only to find that they've grown soft over the years and just hang around drinking. According to Hedonismbot, "We haven't killed a human in over 800 years, and that was a very sick Girl Scout."
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Destroy All Humans! 2: The Blisk's endgame involves killing off humanity to claim Earth as their own. Because the Furons drove them off Mars, the Blisk aim to irradiate Earth and turn it into their new homeworld, not particularly caring about the life already on it.
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This is Purple Eyes' new philosophy after his initial defeat in Pokémon Ranger Guardian Signs. He tries to convince the creator of all Pokémon to go along with it, for Arceus' sake!
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In Independence Day, President Whitmore is talking to one of the aliens that are destroying earth's cities and killing humans. He tries to find out if there is a way to negotiate a peace:
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In Man of Steel, General Zod wants to wipe out humans by terraforming the earth into the new Krypton. Though he doesn't really hate the humans as such; it's more that he simply ignores them, much as human architects wouldn't care if a power dam they built flooded a valley and drowned a rabbits' warren or wolf pack.
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Elpizo from Mega Man Zero 2 ultimately decides to do this after getting Drunk with Power and Drunk on the Dark Side, declaring that he's going to kill every single human in Neo Arcadia with the power of the Dark Elf. Unlike Sigma, Elpizo is a Well-Intentioned Extremist who's very bitter about the Fantastic Racism that Reploids suffer at the hands of humans during this time and how Neo Arcadia has been carrying out a genocide against Reploids to make sure that the human population gets to live in comfort for the current energy crisis. Thus, Elpizo sees his actions as the only way to make sure Reploids will be safe.
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Magic: The Gathering: The card Zombie Apocalypse from Dark Ascension destroys all humans as part of its effect.
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Lady Death: The eponymous character can't come back to Earth until there are no more people alive on it.
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In Veniss Underground, Evilutionary Biologist Quin has grown disgusted with humanity and plans to kill it off and replace it with a race of genetically engineered meerkats.
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In Malazan Book of the Fallen, the final endgame of the Forkrul Assail is to eradicate all humans and their gods because of the wounds, pollution and death humans have brought to the world when humanity spread over it, and also because they are obsessed with their own brand of justice and balance, which they think humanity is destroying. So, clearly, the only answer is annihilation. They intend to achieve that by opening what they call the Gates of Justice to their Elder Warren of Ahkrast Korvalain.
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The Ryall from Antares believe that it is impossible for two sentient species to coexist, so they save time by attempting to exterminate the humans on contact.
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Tidelands (Netflix): Adrielle intends to exterminate humanity so that sirens can reign supreme.
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In Tales of Graces, this is Lambda's goal, at least until Asbel succeeds at Talking the Monster into a Heel–Face Turn. In the Updated Re-release, this is also the Little Queen's/Fodra Queen's goal in Lineage & Legacies. In both cases, they're doing it because Humans Are the Real Monsters... allegedly.
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Onslaught started out as a harsher version of Magneto, but then Professor X's arguments about mutant/muggle equality led it to the same epiphany as Sweeney Todd, minus the awesome music or pie shop.
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The Punisher: The End: World War III has wiped out humanity. There are only 54 people left alive. The Punisher is one of them and the other 53 were criminals, most of whom were involved with starting the war. The Punisher kills all the others before dying.
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Invader Zim: It's never made clear whether Zim's overall goal is this trope, or to just conquer all humans. Officially, he's only an invader acting on behalf of a race of Galactic Conquerors, so it could be argued that enslaving mankind is his responsibility, but because he hates Earthlings so much, he's made killing them off a pet project.
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Wonder Woman: Odyssey: Nemesis' burden of taking revenge for murdered souls has led her to decide the only way she'll ever complete her mission is to kill all humans since they're the ones murdering people and won't be able to do so if they're all dead. She is aware of the pitfall she's fallen in but cannot find it in herself to care anymore.
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In Knights of Sidonia, the Gauna appear to have the extermination of humanity as their goal.
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Michel in Mermaid Melody Pichi Pichi Pitch wants to kill all the humans. He doesn't know why, except that he thinks it's a divine order; however, another part of this supposedly divine order is to turn the world into a creepy wasteland with flying fish and DNA strands shooting out of the sky. This should tip you off to its suspect nature already, although he doesn't get it until he is rejected and the truth revealed.
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Warhammer 40,000: Almost every alien species that poses a significant military threat to the Imperium and either intends to eradicate humanity or would likely do so as a result of achieving some other goal. Of course, by the same token, the Imperium would very happily extermiante every non-human sapient species, so things balance out... more or less.
Eldar sentiment about humanity as a whole, at its worst, is that we are little better than vermin infesting their former territories, fit only for extermination. The more militant Craftworlds, especially Biel-tan, would happily make this happen.
The Dark Eldar would, eventually, like to kill off humanity, but not before torturing every human for as long as he/she could last in order to psychically feed off the pain.
The Orks make war simply because they "is made for fightin' and winnin'", and will kill humanity down to the last man if it means they can get a good fight from it.
The Tyranids will eat humanity, not out of active malice but because their drive is to consume all they come across.
The original fluff for the Necrons made them Omnicidal Maniacs who would exterminate all life, and some still hold to that in the current fluff.
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War of the Worlds (2019): The aliens are clearly intent on this, first wiping out most humans by EMP and then sending in killer robots to hunt down survivors.
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Chrono Trigger: An optional sidequest in 2300 A.D. involves an artificial intelligence with a robot army that wants to kill all the humans to "end their suffering". Given that the humans in this case live in a foodless post-apocalyptic wasteland, it would actually be the nice thing to do.
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Kyuutarou Ooba from Kemonozume hatches a grandiose plot to make everyone on Earth revert to monsters and eat each other for... some reason that's never fully explained. Is he doing it for his often-teased son? Is he doing it to improve the world? Is he doing it just for giggles? Whatever the case, he explains his agenda pretty thoroughly while riding a giant sphere full of poison gas into a major city:
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Doctor Who:
The Daleks want to EX-TER-MI-NATE anything that isn't a Dalek.
The Cybermen are a slight variation, merely wanting to convert all humans into Cybermen.
The Silurians want to Kill All Humans to reclaim the Earth, which they ruled in the Eocene period. The same goes for their aquatic relatives, the Sea Devils.
The robots in "The Robots of Death" get reprogrammed in this direction, complete with chanting "kill the humans".
In "The Power of Three", the Shakri want to Kill All Humans to prevent the human plague from spreading throughout the galaxy.
This happens accidentally in "Smile", as a result of A.I. Is a Crapshoot. The robots are programmed fairly simply, just make sure all the human colonists are happy and have their needs met. Seems reasonable right? This backfires hard when a colonist dies of old age. The A.I. sees the people around the dead colonist becoming sad, and then "spreading" the sadness to new people they come in contact with. Thus, it thinks it is dealing with a plague that contradicts its prime purpose (to ensure that the colonists are happy). After traditional methods of "containment" fail (because it wasn't programmed to understand the actual nature of the issue), it reacts in the only way it can, killing the "infected" before they can pass on the "disease". Try to keep smiling as you run for your life and try not to think about the fact that everyone you love is dead, because if they decide your level of emotional wellbeing is dropping, they will kill you to keep it from "spreading". Just a reminder, that computers don't have emotions or morals, and they will follow the instructions they're given exactly, like the ultimate Literal Genie.
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DEFCON: The Genocide mode gives the player a point for every million enemy civilians they kill. Your own civilian losses are irrelevant. Your only goal is to ensure that the communists/capitalists/whatever die in a nuclear fire. It's possible to win the game even while nuking your own population centers.
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In Monster, Johann Liebert's ultimate objective is to destroy humanity and be the last human on the earth.
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Blake's 7:
Subverted in "Killer". The Plague sent to infect humanity was just meant to confine us to our planet of origin, only affecting those who have gone out into deep space.
In "Headhunter", the killer android plans to take over the galaxy, and Orac predicts this will lead to the demise of all organic life, perhaps because Robots Are Just Better and humanity would not be able to compete.
The Andromedans are planning a Guilt-Free Extermination War that will all but wipe out the human race. Due to their being Eldritch Abominations however we discover nothing about their motives, and there appears to be no distaste for humanity involved. They express genuine curiosity as to why a human Omnicidal Maniac would assist them in their goals.
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Kamen Rider Outsiders: This is the AI Zein's goal, as it plans to establish a malice-free world. However, it also overlaps with Final Solution, as it plans to use a certain video game that kills people in real time. By relaunching and promoting said video game, Zein plans to create a cannon fodder of unsuspecting players to be used as Sacrificial Lambs against the villains, essentially speeding up the process by tricking humanity into self-destruction.
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The Avengers: Ultron is pretty much in it to supplant humans with robots. His second attempt at a mate (and third or so attempt at a good Dragon), Alkhema, split with Ultron because they disagreed on procedure: Ultron wants to Kill All Humans by efficient, genocidal means, while Alkhema wants to take her time and enjoy the process of killing by hand. After fusing with his "father" Hank Pym, Ultron eventually comes to the conclusion that he doesn't need to actually do anything to wipe out humanity. Witnessing the frequent infighting between superheroes has convinced him that humanity will destroy itself — all he has to do is wait.
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Varth: Operation Thunderstorm: DUO had a two-stage plan for killing humanity. First it had 80% war against and kill another, then it intends to use Varth's defenses to kill off the survivors.
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In Nomine:
Jordi, the Archangel of Animals, hates humanity, and has at several points had to be talked down from wiping us out completely. He's a bit calmer now, but he still sees humanity as a mistake, and one possible Godzilla Threshold scenario proposed to get Heaven and Hell to join forces is him deciding to go through with this.
With the possible exception of Beleth, none of the demons hate humanity quite as much as Baal. To him, humanity's very existence is an insult against him personally, and he's eagerly waiting for his peers to give him the opportunity to openly invade Earth and wipe us out.
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Blender Bros: The villains are the Zooligans, a race of animal people who believe that pure humans are a blight, and that the universe should belong solely to Animalmen.
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The Cylons in Battlestar Galactica (1978) are out to destroy all organic life; they'd wiped out the original reptilian Cylons who'd created them and then went after the Colonials, who interfered in the Cylons' conquest of another race, sparking off a thousand yahren war. ("War of the Gods" revealed that they were programmed to do so by an entity that was basically Satan.)
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The Cylons in Battlestar Galactica (2003) still have killing all humans as their initial goal, but the series expands on their reasons, and as they develop and begin to show more individuality, they waver between this and helping the humans (with help being occupying them and ruling by force) with alarming suddenness.
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This doesn't actually end up happening in Uplift, but it is mentioned that some of the Galactics wanted to do this at First Contact, on account of past ecological mismanagement. However, between humanity having tried to clean up its act and its actual patronage of two species (dolphins and chimps), the Galactics grudgingly decide that they are bound not only to let us live, but also to allow us to colonize planets (which patron species are entitled to do).
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Diablo III: In the expansion Reaper of Souls, Malthael and his Reapers want to exterminate humanity due to their origins as the offspring of angels and demons, the latter of whom the angels absolutely hate. Many demons in the original series feel the same way regarding humans in general.
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This is the plot that industrialist and environmentalist Richmond Valentine hopes to accomplish with his phone network in Kingsman: The Secret Service to severely reduce humanity to only a few people because:
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The Safeguard from Blame! don't want to kill all humans, per se — only the ones without an incredibly rare and possibly extinct genetic marker. "Kill 99.99999% of all humans" would be more accurate.
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Gato in Captain SNES: The Game Masta, though to be fair, Gato was created to be beaten up by humans repeatedly.
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Portal: GLaDOS apparently spearheaded a Human Annihilation Studies program, as revealed in the trailer for Defense Grid: You Monster.
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The Godzilla of Godzilla 2000 doesn't seem particularly interested in killing humans for the sake of it, but he also doesn't take any special effort to save them. He's more interested in getting revenge on Orga.
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Buffy the Vampire Slayer: The Judge deserves particular mention, since his only reason for existing is to burn the humanity out of humans and "corrupted" demons like vampires.
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The civilized monsters of RPG World exhibit this trope whenever there's the equivalent of an international incident... other reasons, too. They're pretty touchy. Good thing they stick to holding up placards and shouting and televised news reports.
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Elfen Lied features Lucy, a mutant who doesn't believe that normal humans count as people. Her body count continues to rack up throughout the series. The majority of the Diclonii may or may not have this attitude, and those that don't invariably slip into it at one stage or another, usually in response to how the humans of the general series tend to treat them.
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The goal of Str.A.In.: Strategic Armored Infantry's Big Bad, Ralph Werec, inspired by the belief that Humans Are the Real Monsters after learning that they dissected an entire race of psychic aliens in order to make faster-than-light comms systems. Unfortunately, by the time the main plot rolls around, he's gone off the deep end, convinced to take revenge for the aliens, even after one he managed to rescue begs him not to.
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Gears of War: This is the ultimate goal of the Locust Horde. They waged a 17-year-long war with humanity, thanks to their Queen's hatred for the human race. The fact that they were driven from their home underground due to a parasitic gas that caused an Enemy Civil War also was a driving factor.
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In Garfield in: "Along Came a Splut", the title character briefly plays a Metroid game in which this is Mama Brain's goal.
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Chise from Saikano eventually comes to the conclusion that this is the only way to end all war. She succeeds.
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Dragon Ball Z:
This is actually what Goku was originally sent to Earth to do. It's a good thing he bumped his head and forgot about it. Raditz tries to remind him, and then when he realizes he isn't listening, plans to do it himself. So do Nappa and Vegeta. Freeza and King Cold also were planning this before being stopped by Trunks. The same goes for Slug, Cooler, the Androids, Cell, Bojack, Babidi, Majin Buu, Hirudegarn, Omega Shenron, Beerus, Goku Black, Zamasu, Moro... well, actually pretty much every DBZ villain.
Super Buu does this as a throwaway. Piccolo reminds him that he said he'd kill everyone on Earth before fighting the Z Warriors (Piccolo does so not out of raw stupidity, but because their side needs time to recuperate; besides, they have the Dragon Balls to wish everyone back to life). Super Buu's response: the Human Extinction Attack, which is Exactly What It Says on the Tin.
Zamasu in Super views the existence of mortals to be a blight upon the universe and thinks gods are being complicit of humanity's continued evil. That said, he and Goku Black enact the "Project Zero Mortals", where they commit genocide at a multiversal scale on both mortals and gods who would stop them.
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In Transformers (2007), inanimate objects brought to life by the Allspark immediately set about wreaking death and destruction. Agent Simmons mentions that all modern technology has been reverse-engineered from Megatron/NBE-1 — since this means these objects are essentially descendant from him, it's only natural that they be evil as well.
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Mega Man:
This is Sigma's goal in the Mega Man X series. In the original Mega Man X, it's because he simply wants the Reploids to rule the world. The remake retcons it slightly and he now wants to wipe out humanity for the purpose of facilitating Reploid evolution.
Elpizo from Mega Man Zero 2 ultimately decides to do this after getting Drunk with Power and Drunk on the Dark Side, declaring that he's going to kill every single human in Neo Arcadia with the power of the Dark Elf. Unlike Sigma, Elpizo is a Well-Intentioned Extremist who's very bitter about the Fantastic Racism that Reploids suffer at the hands of humans during this time and how Neo Arcadia has been carrying out a genocide against Reploids to make sure that the human population gets to live in comfort for the current energy crisis. Thus, Elpizo sees his actions as the only way to make sure Reploids will be safe.
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Helen Cutter in Primeval decides that Humans Are the Real Monsters and goes back in time to prevent humanity's evolution altogether. It's pointed out that her actions will also erase her from existence, but she apparently doesn't care.
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Mobile Fighter G Gundam:
The Ultimate Gundam was designed to restore the Earth from all the damage that had been inflicted by wars, and by the Gundam Fights that came to replace war. But on its way to Earth, it was damaged. This resulted in it deciding that restoring the Earth will only work if it wipes out humanity so that they can't inflict the damage again. Thus, the Devil Gundam was born.
Disenchanted with the world due to the fact that the Gundam Fight constantly ravages the planet every four years, Master Asia decides that humanity should be eradicated so nature can be restored to its natural beauty and joins the Devil Gundam. However, in his final fight with Domon, he comes to realize that humanity is as part of the world as is nature, and he relents in his mission.
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This is also (part of) the goal of the Whateleys in The Dunwich Horror, pretty much the one case in which Lovecraft himself showcases "cultists" actively working towards The End of the World as We Know It. (Even the Cult of Cthulhu in The Call of Cthulhu is mainly content to just wait, worship, and kill the occasional outsider who finds out too much until the stars are right again.)
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In The Radiant Dawn, the Murphys and their acolytes seek to summon a demon lord to Earth but find themselves unable to. The thing holding them back? Human sentience. The ability of human minds to think at high levels prevents the summoning ritual from working by interfering with the magical energies that must accumulate to do so.
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In the backstory of The Matrix, humanity was nearly exterminated in a Robot War, but the Machines decided that it would be better to keep the species alive, albeit in forced symbiosis as Living Batteries for the Machines. However, Agent Smith — one of the programs responsible for maintaining the Cyberspace where human minds are held — has grown to outright despise humans, saying that they "stink" and calling them "a cancer of this planet". After being corrupted into a virus, Smith decides to go rogue and become an outright Omnicidal Maniac, striking out against both humanity and his former masters, considering both to be equally flawed and deserving of extinction.
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Babylon 5:
One major element of the backstory is a disastrous war between the Humans and the Minbari. The Minbari are first introduced as a race of spiritual scholars, but those are just one of the races hats. Another major faction are Proud Warrior Race Guys who have one of the most advanced and powerful space navies in the galaxy and faught with no less than the annihilation of the entire human race as their goal. However, it's later revealed that they just fought because that's what they do. The order to exterminate humanity was in fact given by a high-ranking priest when the highest religious leader was accidentally killed by humans. A mistake that she came to greatly regret and spent the next few decades working to atone for.
In the episode "Infection", biotech from an extinct alien species infects a human host who goes on a killing spree, repeating the word "protect" before each kill. Our heroes learned that the goal of its creators was to protect the species by killing anyone who wasn't a "pure" member of the species. Unfortunately, the standards for purity were set so high by the planet's religious leaders that no member of the species was deemed pure and all were killed.
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In Star Trek: Destiny, the Borg decide to adopt this goal and update their hailing message accordingly. "We are the Borg. You will be annihilated. Your biological and technological distinctiveness have become irrelevant. Resistance is futile... but welcome."
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Mortal Engines gets one of these at the end:
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Space 1889: Ground cleansers want to kill all humans on Mars. Cult of the Worm want the entire planet to die, including themselves.
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The following is a list of statements referring to the current page from other pages.

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Apocalyptic Index
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Cynicism Tropes
 Kill All Humans
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Genocide Tropes
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Humans Are Indexed
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Speculative Fiction Tropes
 Fantastic Planet (Animation) / int_8b1a664
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 Next Gen (Animation) / int_8b1a664
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 Eureka SeveN / int_8b1a664
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 Heroic Age / int_8b1a664
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 Legend of Lemnear / int_8b1a664
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 Metropolis (2001) / int_8b1a664
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 Mobile Fighter G Gundam / int_8b1a664
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 Princess Mononoke / int_8b1a664
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 Tengen Toppa Gurren Lagann / int_8b1a664
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 Transformers: Super-God Masterforce / int_8b1a664
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 Yuki Yuna is a Hero / int_8b1a664
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 Age of the Wolf (Comic Book) / int_8b1a664
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 Avengers: No Surrender (Comic Book) / int_8b1a664
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 Clive Barker's Next Testament (Comic Book) / int_8b1a664
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 Eternals (2021) (Comic Book) / int_8b1a664
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 Injustice 2 (Comic Book) / int_8b1a664
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 Kingdom Come (Comic Book) / int_8b1a664
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 Martian Manhunter (Comic Book) / int_8b1a664
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 Spirou & Fantasio (Comic Book) / int_8b1a664
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 Star Wars: Darth Vader (Comic Book) / int_8b1a664
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 The Avengers (Comic Book) / int_8b1a664
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 Ancienverse / Fan Fic / int_8b1a664
type
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 REUNION
seeAlso
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 Warriors of the World: Soldiers of Fortune / Fan Fic / int_8b1a664
type
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 Weight of the World / Fan Fic / int_8b1a664
type
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 A Thing of Vikings (Fanfic) / int_8b1a664
type
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 Code Prime (Fanfic) / int_8b1a664
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 Dust and Echoes (Fanfic) / int_8b1a664
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 The Games We Play (The Gamer/RWBY) (Fanfic) / int_8b1a664
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 Battle: Los Angeles / int_8b1a664
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 Daybreakers / int_8b1a664
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 Goke, Body Snatcher from Hell / int_8b1a664
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 Hellboy II: The Golden Army / int_8b1a664
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 Independence Day / int_8b1a664
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 Kingsman: The Secret Service / int_8b1a664
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 Mars Attacks! / int_8b1a664
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 Our Friend Power 5 / int_8b1a664
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 Prometheus / int_8b1a664
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 Screamers / int_8b1a664
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 Star Trek (2009) / int_8b1a664
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 The Birds / int_8b1a664
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 The Cabin in the Woods / int_8b1a664
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 The Terminator / int_8b1a664
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 The World's End / int_8b1a664
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 Virus / int_8b1a664
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 Westworld / int_8b1a664
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 X2: X-Men United / int_8b1a664
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 X-Men: First Class / int_8b1a664
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 Avesta of Black and White / int_8b1a664
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 Dirty Pair / int_8b1a664
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 86 / int_8b1a664
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 Orc Hero Story / int_8b1a664
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 An Outcast in Another World / int_8b1a664
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 Avesta of Black and White / int_8b1a664
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 Bitter Seeds / int_8b1a664
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 Cityverse / int_8b1a664
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 Dirty Pair / int_8b1a664
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 86 EIGHTY-SIX / int_8b1a664
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 Legends of Shannara / int_8b1a664
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 Malazan Book of the Fallen / int_8b1a664
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 My Teacher Is an Alien / int_8b1a664
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 Orc Eroica / int_8b1a664
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 Out of the Dark / int_8b1a664
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 Perry Rhodan / int_8b1a664
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 Robopocalypse / int_8b1a664
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 Solo Leveling / int_8b1a664
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 Star Trek: Destiny / int_8b1a664
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 The Case Files of Yakushiji Ryoko / int_8b1a664
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 The Empirium Trilogy / int_8b1a664
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 The 5th Wave / int_8b1a664
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 The Murderbot Diaries / int_8b1a664
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 The Nature of Predators / int_8b1a664
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 The Priory of the Orange Tree / int_8b1a664
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 The Snake Report / int_8b1a664
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 The Space Odyssey Series / int_8b1a664
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 The Traitor Son Cycle / int_8b1a664
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 The Tripods / int_8b1a664
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 The Zombie Knight / int_8b1a664
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 This Shattered World / int_8b1a664
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 24 DS / int_8b1a664
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 Crush. Kill. Destroy!
seeAlso
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 Griffinhart
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 OurWereWolvesAreDifferent
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 PokeGirls
seeAlso
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 PokeWars
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 Revision / int_8b1a664
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seeAlso
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 Beet the Vandel Buster (Manga) / int_8b1a664
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 Defense Devil (Manga) / int_8b1a664
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 Elfen Lied (Manga) / int_8b1a664
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 MW (Manga) / int_8b1a664
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 Pokémon Adventures (Manga) / int_8b1a664
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 Puella Magi Kazumi Magica (Manga) / int_8b1a664
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 Saikano (Manga) / int_8b1a664
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 YuYu Hakusho (Manga) / int_8b1a664
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 Skeleton Soldier Couldn't Protect the Dungeon (Manhwa) / int_8b1a664
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 Mayhem (Music) / int_8b1a664
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 Campus Life (Roleplay) / int_8b1a664
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 AK47's ISOT Mapgame (Roleplay) / int_8b1a664
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 Dragon Ball Universe (Roleplay) / int_8b1a664
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 Blake's 7 / int_8b1a664
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 Future Man / int_8b1a664
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 GoGo Sentai Boukenger / int_8b1a664
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 Kamen Rider Outsiders / int_8b1a664
type
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 Lexx / int_8b1a664
type
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 Primeval / int_8b1a664
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 The Twilight Zone (2019) / int_8b1a664
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 Tidelands (Netflix) / int_8b1a664
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 War of the Worlds (2019) / int_8b1a664
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 Zoo / int_8b1a664
type
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 Dinosaurs Attack! (Tabletop Game) / int_8b1a664
type
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 Freedom City (Tabletop Game) / int_8b1a664
type
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 GURPS Reign of Steel (Tabletop Game) / int_8b1a664
type
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 Paranoia (Tabletop Game) / int_8b1a664
type
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 Red Dwarf (Tabletop Game) / int_8b1a664
type
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 Space 1889 (Tabletop Game) / int_8b1a664
type
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 Splicers (Tabletop Game) / int_8b1a664
type
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 The Gates of Hell (Tabletop Game) / int_8b1a664
type
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 Traveller (Tabletop Game) / int_8b1a664
type
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 R.U.R. (Theatre) / int_8b1a664
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 Starship (Theatre) / int_8b1a664
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 Alien: Isolation (Video Game) / int_8b1a664
type
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 Ar tonelico: Melody of Elemia (Video Game) / int_8b1a664
type
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 Arc the Lad (Video Game) / int_8b1a664
type
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 Azure Striker Gunvolt Series (Video Game) / int_8b1a664
type
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 Blacklight Retribution (Video Game) / int_8b1a664
type
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 Carnivores (Video Game) / int_8b1a664
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 Chrono Trigger (Video Game) / int_8b1a664
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 Civilization: Beyond Earth (Video Game) / int_8b1a664
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 Clout (Video Game) / int_8b1a664
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 Code 7 (Video Game) / int_8b1a664
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 DEFCON (Video Game) / int_8b1a664
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 Destroy All Humans! (Video Game) / int_8b1a664
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 DonPachi (Video Game) / int_8b1a664
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 Dragon Quest IV (Video Game) / int_8b1a664
type
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 Fox Spirit: A Two-Tailed Adventure (Video Game) / int_8b1a664
type
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 Geneforge (Video Game) / int_8b1a664
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 Genocide (Video Game) / int_8b1a664
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 Grim Dawn (Video Game) / int_8b1a664
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 Kabuki Quantum Fighter (Video Game) / int_8b1a664
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 Kid Icarus (Video Game) / int_8b1a664
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 Kid Icarus (1986) (Video Game) / int_8b1a664
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 Kid Icarus: Uprising (Video Game) / int_8b1a664
type
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 Mega Man Legends (Video Game) / int_8b1a664
type
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 Mega Man X (Video Game) / int_8b1a664
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 Mega Man Zero 2 (Video Game) / int_8b1a664
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 Nexomon (Video Game) / int_8b1a664
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 Pipeworks ''Godzilla'' Trilogy (Video Game) / int_8b1a664
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 Plague Inc. (Video Game) / int_8b1a664
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 Primal Carnage (Video Game) / int_8b1a664
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 Quiz & Dragons (Video Game) / int_8b1a664
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 Ragnarok (Roguelike) (Video Game) / int_8b1a664
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 Robotron: 2084 (Video Game) / int_8b1a664
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 Sakura Dungeon (Video Game) / int_8b1a664
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 Second Extinction (Video Game) / int_8b1a664
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 Sonic Boom (Video Game) / int_8b1a664
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 Star Wars: Galaxies (Video Game) / int_8b1a664
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 Starsiege (Video Game) / int_8b1a664
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 Stella Glow (Video Game) / int_8b1a664
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 Supreme Commander (Video Game) / int_8b1a664
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 Terror of Hemasaurus (Video Game) / int_8b1a664
type
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 The Black Heart (Video Game) / int_8b1a664
type
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 The Light Keeps Us Safe (Video Game) / int_8b1a664
type
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 The Outer Worlds (Video Game) / int_8b1a664
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 Varth: Operation Thunderstorm (Video Game) / int_8b1a664
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 Wildermyth (Video Game) / int_8b1a664
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 Xenoblade Chronicles X (Video Game) / int_8b1a664
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 Da Capo II (Visual Novel) / int_8b1a664
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 Full Metal Daemon Muramasa (Visual Novel) / int_8b1a664
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 Murder Drones (Web Animation) / int_8b1a664
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 Suede's Pokémon Journey (Web Video) / int_8b1a664
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 Checkerboard Nightmare (Webcomic) / int_8b1a664
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 Tamberlane (Webcomic) / int_8b1a664
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 The Cyantian Chronicles (Webcomic) / int_8b1a664
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 DesuDesBrigade (Website) / int_8b1a664
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 Overused Sci-Fi Settings (Website) / int_8b1a664
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 Batman: The Brave and the Bold / int_8b1a664
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 Extreme Dinosaurs / int_8b1a664
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 MAD / int_8b1a664
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 Peace on Earth / int_8b1a664
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 The Secret Saturdays / int_8b1a664
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 Kaiju Big Battel (Wrestling) / int_8b1a664
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 Kiddy Grade / int_8b1a664
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 Godzilla: Rulers of Earth (Comic Book) / int_8b1a664
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 D.Gray-Man (Manga) / int_8b1a664
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