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Opposite-Sex Clone

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While clones and most other sorts of sci-fi duplicates are identical to the original character and, by definition, the same sex, exceptions do exist. The idea dates at least from Nine Lives by Ursula K. Le Guin (1969), where recognized geniuses are routinely cloned in large mixed-sex groups and Time Enough for Love by Robert Heinlein (1973), where the opposite sex clones become sexual partners of the original. Nowadays the trope is more often used as a quick way of producing a Distaff Counterpart rather than for titillation. Merely being of the opposite sex of his or her original greatly increases the chance of the clone surviving the denouement and showing up in a future story. This way writers can invoke the First Law of Gender Bending without sacrificing an original-sex character they've grown fond of.
Biologically, this is somewhat plausible for male-to-female cloning, because a male has an X-chromosome that can be doubled to produce a female clone, as in Garrett's poem and Heinlein's novel.note Strictly speaking, you don't even need the second X chromosome, though omitting it is a good way to kill 99% of your fetuses and give the surviving 1% Turner syndrome. Alternatively, the SRY gene, which causes maleness, can be removed from the Y chromosome. For female-to-male cloning, the Y chromosome would have to come from another subject, preferably a paternal relative and most ideally the father, as if the original subject were a male, she would have had a Y chromosome virtually identical to her father's. Nevertheless, this would technically not be a pure clone. A Y chromosome could be formed from one of the X-chromosomes, which would require absurd amounts of genetic engineering and amount to simple fiat anyway. Alternatively, the SRY gene can be implanted in one of the X chromosomes to create a sterile clone that appears male. Somewhat fittingly when given the above, the majority of these characters are female.
If the Opposite-Sex Clone retains the memories and personality of the original this is effectively a Gender Bender, at least from the perspective of the clone.
See Clone Angst for when said clone is upset about their nature. Subtrope of Modified Clone. Compare Distaff Counterpart, Half-Identical Twins and Screw Yourself. See also Trans Audience Interpretation, as that is a common fan explanation as to why this trope occurs.
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Wonder Woman (1987): Kreel biology means that attempting to clone a man may result in a female infant, as is the case for the Emperor.
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Starfield: Hadrian Sanon is the clone daughter of an executed war criminal, and is worried that her father's misdeeds will be used against her. In the conversation where we learn all of this you can reassure her that she is not her father; and when asked how an opposite sex clone is even possible, she will reply "A lot of gene editing."
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X-23 is an Opposite-Sex Clone of Wolverine, developed by Dr. Sarah Kinney as a solution to not being able to recreate a Y chromosome from a sample of Wolverine's DNA. So instead, she doubled the X chromosome.
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Ranma ½:
After accidentally looking into an enchanted mirror, Ranma creates a copy of his female self. She is, of course, infatuated with him. In the end, he accidentally copies his male self and the two copies fall for each other.
In an anime episode, Happosai attempts to split Ranma into male and female forms for his own selfish reasons. However, he misses the fact that, A: Ranma despises him and would never obey him no matter the form, and B: the incense he uses is called Personality Splitter. The result is an Enemy Without situation, as the Clone is a vampiric ghost-like entity that is the living embodiment of Ranma's evil.
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The female Nemu is the clone of the male Mayuri Kurotsuchi in Bleach. It's more apparent when Mayuri doesn't have his make-up on.
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 Bleach (Manga)
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The community-driven interactive fiction MS Paint Adventures: Problem Sleuth introduces a trio of detectives: Problem Sleuth, Ace Dick, and Pickle Inspector ("pickle" in this context is meant to connote "problem"), who, through spirit quests, are psychically linked with female counterparts of themselves, whom they eventually meet in person and are instantly attracted to. Problem Sleuth gets Hysterical Dame, Pickle Inspector gets Nervous Broad, and Ace Dick, lacking the imagination to think of a female counterpart, simply becomes linked to another male version of himself (albeit one who owns a blonde wig).
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Keith Violet of Project ARMS, the one female amongst the many clones of Keith.
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Holy Bibble portrays Eve as this to Adam, since she is created from his rib. Due to the comic's simplistic art style, this is primarily shown by her having a similar curly forelock to him, as well as the same skin and hair colors.
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X-Cellent introduces Phatty, a female clone of Phat, one of the dead members of X-Statix.
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Naruto fanfictions happen to do this a lot to the main character, due to his Opposite Sex Clone actually being real. This is strengthened in the fact that it's not really a clone, but a disguise that quite literally changes Naruto into a girl. He can do this to his clones making literal Opposite Sex Clones.
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In a Valentines episode of House of Mouse, Ludwig Von Drake deduces that the perfect partner for someone would be an Opposite Sex Clone. The two can't stand each other, and she breaks up with himself.
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The Innovators in Mobile Suit Gundam 00. They are all technically genderless but come in pairs; out of the four pairs only one has both members having adopted a persona of the same gender (both male), so each of the other six Innovators has their own opposite sex clone of sorts.
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Used in a classic Supergirl comic where a criminal tries to clone Supergirl in order to use her twin to commit crimes. The (male) twin ends up committing suicide due to an Ethical Conflict between what his criminal creator has told him to do and what his twin wants him to do.
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Majikoi! Love Me Seriously! has Yoshitsune and Benkei, as per their namesakes, are the female clones of the famous historical figures. Seiso is likely this as well, though it's not yet revealed who she's a clone of.
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A variant from the Whateley Universe: In "The Second Book of Jobe", kleptomaniac devisor Belphegor ends up downloading a copy of his own personality into a cloned female drow body based on Jobe's "drow formula" and DNA. Hilarity quite naturally ensues, though the overall awkwardness of the situation (and not just because campus security shows up right the next moment) isn't neglected — for one, both Belphegor and Jobe find themselves promptly declared "Belphoebe"'s parents of record, and there's every reason to believe that she's here to stay because there's in-universe evidence that she's managed to dodge the Clone Degeneration bullet...
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Hero: The Guardian Smurf: Wonder Smurfette is one of the series' main protagonist Hero Smurf, who was created with the magical Mirror of Opposition when lightning struck it, thus creating a second adult female Smurf in the village besides Smurfette.
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In BioShock Infinite, it turns out that Robert Lutece is not Rosalind's twin brother, but rather an opposite-sex version of her from an alternate universe.
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Cartoon band The Plastic E-Gulls have Tina the bass player, a clone of Ian the frontman, made to satisfy the record company's mandatory bass player clause. Ian would happily label her as a Distaff Counterpart if her Cloudcuckoolander persona wasn't in the way.
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In DC Comics Bombshells, Superman is an opposite-sex clone of Supergirl, created by Hugo Strange. He also created a same-sex clone, who is that continuity's Power Girl.
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Subverted in Skin Horse- when the characters travel to an alternate dimension, Tip discovers that this universe's version of him is a woman- but eventually they realize that although they were born at the same time from the same parents, they're no more genetically related than a different brother and sister.
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Bionic Six: Dr. Scarab's attempt to create a female companion resulted in this. Later, his female clone created opposite sex clones of his henchmen.
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Ayakashi Triangle: About half a year after Matsuri was turned from a boy into a girl, exposure to The Corruption somehow resulted in both a male and female Matsuri, each with all of Matsuri's previous memories and personality. Because only the girl has the mark of the initial transformation, it's judged most likely the spell was turned into an ayakashi with a copy of Matsuri's mind, turning the original back into a boy. However, it's entirely possible the boy is a clone, and thus an inversion.
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Johnny Test has at least three female doppelgangers of Johnny. Princess Maribel is by far the most exact and doesn't get an upgrade in hairstyle or even a clothing change aside from a little lipstick. Sissy is the second and Joni West is the last.
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In Kingdom Hearts: 358/2 Days, Xion is a clone of Sora literally made out of memories. It's played with a bit, as what you see while looking at them varies from person to person (such as Xigbar seeing her as Ventus), but the Shapeshifter Default Form is Kairi with black hair.
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DuckTales (2017): The finale shows Webby is some kind of artificial daughter to Scrooge McDuck, which Bradford made because retrieving an Artifact of Doom required a direct descendant of the latter. She's not quite called a "clone", or identical-looking, but no mention is made of adding any other person's DNA. May and June are also genetically Scrooge's daughters, although they were actually made by cloning Webby via magic. Scrooge, for his part, after his initial shock at being called Webby's dad, is elated to find out they're biologically related.
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Red Dwarf:
"Parallel Universe" has opposite-sex versions of the whole crew, where Rimmer's female double (Alternate Universe rather than cloned) comes on to him in a spectacularly unsubtle way, and where Lister proceeds to sleep with and get pregnant by his female counterpart. This episode also features an obvious joke:
"Rimmerworld" has Rimmer try to go the pervy route with this when he winds up stranded on an unoccupied planet. He screws up the cloning, though... several times. Even when he gets it "right", the clone still has his (male) face, but by that time, he's a prisoner of his own male clones and thus has bigger problems...
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Fate Series: A weird one. In real life Arthurian legend, Mordred is the illegitimate son of King Arthur, made through the intervention of Morgan le Fey (exactly what she did varies depending on the legend). In Fate/stay night, one of the first major reveals is that King Arthur is actually female. Many fans assumed that Mordred would therefore be an Opposite-Sex Clone. In Fate/Apocrypha, we find out that Mordred is indeed an Opposite-Sex Clone... except she's still female. Specifically, Artoria was temporarily transformed into a pseudo-male by Merlin, and Artoria's sister Morgan le Fey used the opportunity to get a DNA sample. She then used that to grow a homunculus of the opposite gender, meaning Mordred came out female. Word of God explained some of this before Apocrypha came out.
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The Powerpuff Girls (1998): The Rowdyruff Boys, in a twisted-Evil Counterpart way. They aren't so much clones as bargain-basement knockoffs, made when Mojo Jojo imitated the Powerpuffs' creation using more "manly" ingredients. Despite the resemblance to their counterparts, no one treats them as genetically related. The girls defeat the boys by exploiting their disgust for romantic interest without any sort of incestuous implications.
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Super Robot Wars:
Ingram Prisken and Viletta Vadim were the male and female options for the protagonist of Super Hero Sakusen. The Alpha and Original Generation games re-envision them as this trope, with Viletta being a female clone of Ingram who wouldn't be subjected to the same mind control that he was under.
Kazuma Ardygun has a female clone named Aria Advance. Unlike most examples, she's not a genetic clone, but rather a digital being based off Kazuma's data.
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The Stardoc series has for a main character Cherijo Grey Veil, who is introduced as the daughter of renowned geneticist Dr. Joseph Grey Veil. Later in the series, we discover not only is she a female clone of the good doctor, she was created as a wife for him. Basically, he was such an egomaniac that he felt only his Distaff Counterpart would be a worthy mate. And he was willing to get laws passed declaring her a non-person in order to make sure she had no say in the matter.
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Biting the Sun: The heroine goes male so as to be able to produce sperm which s/he stores, then uses (once she switches back to female) to impregnate herself. It doesn't end up that well...
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In Drakengard 3, each of the Intoners has their own Disciple to serve them as a companion, bodyguard, and to sate their ramped-up sexual needs. Instead of a normal Disciple, One somehow spontaneously created a male clone of herself, who she keeps hidden from the other Intoners as a secret weapon against Zero. He only appears in the main story at the very end of Branch A, as a Diabolus ex Machina who backstabs Zero out of nowhere, but he co-stars in One's DLC missions, turns out to be the founder of the Cult of the Watchers that features so prominently in Drakengard, and is the main character of the Drakengard 3 spinoff manga. And yes, One used her brother to meet her sexual needs as well - she at least felt guilty and conflicted about it, he didn't see what the problem was. And no, he isn't given a name beyond One's Brother, and in Route A's epilogue is able to pass himself off as One to take her place.
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Nintendo Wars: Caulder/Stolos from Advance Wars: Days of Ruin has his 'daughters', Opposite Sex Clones of himself. They don't look that much like each other, so he appears to have fussed about with their genetics a little (which could explain their different eye colors). He does have a male clone as well, Cyrus, but he plays little part in the story.
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Dune:
God-Emperor of Dune: Leto is introduced to Hwi Noree, the new Ixian Ambassador, who turns out to be an Opposite Sex Clone of the previous ambassador, genetically tweaked to be irresistible to the inhuman Leto.
Dune Encyclopedia provides a history of all of Leto II's Duncan Idaho gholas, it includes that the Tleilaxu once provided a female Duncan Idaho ghola in a similar ploy to what the Ixians attempted with Hwi.
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In Mass Effect 2, Miranda Lawson is genetically engineered using her biological "father's" modified genome to be perfect. Unsurprisingly she has some pretty severe daddy issues resulting from what she perceives as her father's egotistical arrogance. Ultimately by the end of 2 and in 3, they turn out to be two VERY different people, with Henry Lawson turning out to be even worse than Miranda described and Miranda showing herself to be a Jerk with a Heart of Gold, with the Jerk part eventually being shed.
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In Magical Girl Lyrical Nanoha StrikerS, Uno of the Numbers Cyborgs was revealed in the Sound Stages to have been created by Jail through cloning, using his own genetic material.
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Getter Robo Armaggedon: the pilot Go is a male Artificial Human made from the DNA of Dr. Saotome's deceased daughter Michiru.
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The web-toon series Bonus Stage featured a female clone of main character Phil Argus as a gag character, once as a "perfect girlfriend", the next as a "cheap ploy for additional viewership" (applified by bunny ears and fox ears (presumably to appeal to a wider spectrum of viewers).
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Traveller: Archduke Norris Aella Aledon never married, but needed an heir, so he had a daughter (Seldrian Aledon) created. Cloning to have children happens so often, there is a term specifically for clone offspring (especially ones created to provide an heir for nobles): "true-son" or "true-daughter".
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In The Sims 2, a cheat can be used to impregnate a Sim by him/herself. Doing this will produce offspring that is a clone of the parent, but it will always be of the opposite sex. Notably, the child Brandi Broke is pregnant with when first played is such a clone, and isn't genetically related to his supposed father at all.
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The King of Fighters series has Kula Diamond, one of the many clones of Kyo Kusanagi. In addition to the sex flip, Kyo's powers over fire became Kula's powers over ice.
The series can be inconsistent about "clones," sometimes using the term to describe unrelated people who have just been altered to be like someone else, and not clones in the normal sense. This makes Kula's status as a clone unclear.
Kula did say in her storyline in KOF 2001 that she was "grown from a petri dish" (at least in the English version, anyway), which would make her fall squarely into this trope.
However, Kula's bio in Maximum Impact 2 hints that she's a clone in the "genetic manipulation" sense (i.e. a normal girl surgically implanted with Kusanagi DNA, much like K' and Nameless). While the MI series is an Alternate Continuity, most of the characters' backstories seem to be unchanged, so...
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Darker than Black Gemini of the Meteor reveals that Suou is an opposite-sex clone that Shion created of himself to pass as his twin sister complete with Fake Memories. The real Suou died during an unrelated assassination attempt.
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BattleTech General Maeve Wolf of Wolf's Dragoons is a female clone of founder Jaime Wolf. Rumors had it she was his illegitimate daughter even though public records claimed her as one of the war orphans the company took in while their own records had her as one of their Trueborn warrior of such mixed heritage that she refused a proper Bloodname.
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In Xenosaga URTV #668, named Citrine is the opposite sex clone of Dimitri Yuriev, as were all of the female variant URTVs.
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In House of Suns, by Alastair Reynolds, the various posthuman clone houses, such as Gentian Line, consist of male and female clones of a single individual.
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Spider-Woman (who later went by Black Widow), in Ultimate Spider-Man. Ultimate Spider-Woman is a clone of Peter Parker, with all of his memories and personality traits - except she's considerably more abrasive, especially to Miles. (They were going to blank her memory and give her an entirely new made-up personality and set of memories, but didn't get around to it before wackiness ensued.)
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In Dragon Tails, when Norman the squirrel orders a clone of himself, he marked the sex box with an F (for "Fine the way it is") and got a female clone. The clone is also a child, since this was done with genetics.
They were also really drunk while designing her genetic pattern, so they made her glow-in-the-dark as well.
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Sliders:
An episode has Quinn meet Logan, his Distaff Counterpart. Turns she actually is him—in this universe Quinn was born a girl. She's also an Evil Twin.
In another episode Quinn is on a talk show and mentions meeting Logan, and of course the host immediately asks if he slept with her. They did kiss, though for his part Quinn was unaware of the connection at the time.
It's interesting that Logan found out that Quinn is her double via a "thermal scan", basically, an advanced biometric system that maps each person's unique "heat signature". The Fridge Logic comes from a man and a woman having the same heat signature, even if they do share the same parents.
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In I Don't Want This Kind of Hero, Tracy is this to Baek Morae, created by a group of scientists in an attempt to duplicate the latter's power of purification. Baek Morae, on his part, considers her existence disgraceful and so tries to kill her when they meet in the present.
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After Fantomex of the Uncanny X-force died, he was going to get a cloned body to come back with. However, he has three different brains and each brain received its own cloned body. The nicest brain got a female body called Cluster.
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In The Bible, it is said that Eve was created out of Adam's rib, making her for all intents and purposes one of these.
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 The Bible
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By the time of Mega Man Zero, the four Guardians were created from Mega Man X's DNA. One of these Guardians is the obviously female Fairy Leviathan.
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In The Guild Bladezz' little sister looks even more like him than you'd expect (the androgynous clothes probably help). This isn't to put her down, if anything it makes Bladezz retro-actively prettier.
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Orphan Black focuses on several clone characters played by Tatiana Maslany. One of them, introduced in Episode 8 of Season 2, is a trans man named Tony (formerly Antoinette). In Season 3, the focus is on Project CASTOR, which involves a series of male clones that are genetic siblings to the female clones. In fact, both lines come from a single donor, who happens to be a genetic chimera, having absorbed her male twin brother in the womb and thus has two sets of DNA.
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Kazuma Ardygun has a female clone named Aria Advance. Unlike most examples, she's not a genetic clone, but rather a digital being based off Kazuma's data.
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In Infinity Train, it's revealed that Hazel, a six-year-old girl is a failed clone of Alrick, Amelia's deceased husband.
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In The Elder Scrolls III: Morrowind, Divayth Fyr (a very powerful, very old wizard), made four female clones of himself: Alfe, Beyte, Delte, and Uupse. They're variously described as wives or daughters. Surprisingly this isn't particularly played for Squick... at least within his tower.
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Endless Space has the Horatio faction, an array of clones of ultra-rich Horatio the First. Some of them are female, because Horatio got bored with just his male clones.
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Knights of Sidonia: Norio Kunato's "sister" Mozuku is in fact a clone of himself, but altered to be female. She takes care of all of Norio's responsibilities as head of the Kunato family while he devotes his time to piloting, and is mostly just seen as an extension of Norio himself.
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Logan: Laura was created from samples of Wolverine's blood, doubling the X-chromosome.
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Danielle "Dani" Phantom in Danny Phantom. She and Danny continue to call each other "cousins" even after she reveals the truth about what she is.
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Genome: In Dances on the Snow, a genius geneticist named Edward Garlitski manages to create a female clone of himself named Ada Snezhinskaya. She shares his ambition and a vision of a world where genetic engineering is the norm. However, they have different ideas on how to achieve this goal. He chooses to work within the system by perfecting genetic engineering (in another book he is hailed as the father of genetic engineering). She decides that the entire society needs to be remade through political means. She creates hundreds of clones of herself and Edward and sends them out throughout The Empire to be adopted by unsuspecting parents. She then plots a rebellion, which would result in her ruling with her clones. Her plan fails but Garlitski's succeeds.
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Transformers: Animated:
Each of Starscream's clones represents some facet of his personality, which includes a female one (retroactively named Slipstream)—who refuses to explain what part of his personality she represents. Fan theories range from his ambition, to his feminine side, to his opportunism, to his treachery, to his... ah, feelings for Megatron. Word of God has deemed it a Riddle for the Ages, and won't even say if Slipstream herself knows.
Sari Sumdac seems to be a partial example: She is an organic Cybertroninan, but looks like the daughter of her human "father" Isaac Sumdac. Even besides sexual characteristics, the resemblance is far from identical. They share skintone, but not hair or eye color. It's not clear if this was because her protoform was designated to be female, or it just randomly became such.
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El Goonish Shive had protagonist Elliot using an ancient magical artifact to try to undo a Magitek Gender Bender, inadvertently creating Ellen in the process. She was "born" with a perfect copy of Elliot's memories and personality (though she says the memories feel more like stuff she learned, rather than experiences), but her initial Clone Angst and subsequent (successful) attempts to establish her own identity led to Divergent Character Evolution, so she isn't a simple Distaff Counterpart. People calling her a clone (before getting to know her) is a huge Berserk Button. More than a few scenes make it clear that the classic sex partner idea seriously squicks both of them, since they genuinely care about each other like any two siblings would. Elliot in particular has gone on record saying that his first thought when he saw Ellen mid-freakout was "She's family, help her.". Furthermore, since Ellen was split off by the Dewitchery Diamond, Elliot can be considered Ellen's father and (since this is El Goonish Shive and a Gender Bender was inevitably involved) her mother as well. Unfortunately, all of this (plus Elliot's Chronic Hero Syndrome and Ellen's initial Clone Angst) causes him to treat her like a little sister, which tends to annoy her no end.
This potentially may get even more complicated, now that Magus (a Alternate Universe version of Ellen who had used Gender Bender magic in his home worldnote  while he excuses this on some rather sketchy logic about physical strength, the evidence seems to point to this Ellen being Transgender, hence the switch before getting trapped in the EGS universe in a ghost-like state) is now walking around in a a male Dewitchery Diamond duplicate of Elliot's body. For now, Magus is avoiding the other two, but it is likely that he will re-appear eventually.
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One Judge Dredd story set during a flashback to Chaos Day portrayed a group of cadets trying to survive. One of them is stated to be a Dredd clone. Falcone is the obvious, but wrong, candidate. Turns out the clone is female. And pregnant.
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Doctor Who: In "The Doctor's Daughter", a female Truly Single Parent-offspring is made of the Tenth Doctor. She's a genetic duplicate made of a tissue sample, entirely against his will. The relationship between them is presented as father/daughter throughout, as she was created from splitting his chromosomes then randomly recombining them — like sexual reproduction, but him being both parents. The Doctor calls her a "generated anomaly". Donna shortens that to "Jenny". note The actress that played Jenny is the daughter of the actor who played the Fifth Doctor, and later married the actor who played the Tenth Doctor. So she's now a Doctor's daughter who played the Doctor's daughter and then had the Doctor's daughter. Gallifreyan DNA is weird.
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Forges of Mars: The scientist Linya Tychon is a female clone of her father Vitali Tychon. He’d intended her to be male like himself, a carbon copy existing solely to carry on his work when he died, but an error in the creation process altered her sex and inspired him to treat her like a daughter instead.
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Yu-Gi-Oh!, it isn't a clone exactly, but the digital copy of Mokuba Kaiba that Seto Kaiba creates in a video game is Princess Adina. It makes a bit more sense in the Japanese version, where the Big 5 programmed the female Mokuba rather than Kaiba.
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Not an example, but in Dumbing of Age, Sarah refers to Joyce's nearly-identical older brother actually sister Joshua as this.
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The title character of Battle Angel Alita: Last Order and several others are cyborg clones of the same woman. Sechs was original female, but decides to alter their body to be male.
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Otherland: The Corrupt Corporate Executive Felix Jongleur's daughter is a clone of himself. She's actually a byproduct one of his early attempts to make himself immortal. The idea was to have a clone of himself implanted in a surrogate mother. Of course, the child would need a similar upbringing to his own to produce an effective copy. To this end, Jongleur wanted the surrogate mother to be like his own mother. Unfortunately, he couldn't bring himself to unearth her body... so instead, he made an Opposite-Sex Clone of himself. That's right: he intended to impregnate an opposite-sex version of himself... with himself. Very Squick. Fortunately, the project never went beyond the initial stages because a far more appealing (yet no less unethical) option presented itself, so Jongleur adopted the Opposite Sex Clone for his daughter.
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Star Wars: The Bad Batch has introduced a single female clone of the very masculine Jango Fett: Omega, who is not under the control of Order 66 and has joined the Bad Batch. The season two finale introduced another female clone in Dr. Emerie Karr who works for the Empire.
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Arcueid of Tsukihime is more or less a female clone of Crimson Moon Brunestud, the Ultimate Life Form of the Moon and the original template of all Nasuverse vampires. She wasn't intentionally created as such, but as the most powerful True Ancestor to have ever existed, she is, per Nasuverse logic (that copies are always inferior to their originals), the closest it gets to a being a carbon copy of the original vampire, Crimson Moon (who was a guy).
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In Spider-Gwen, The Falcon is the teenage, male clone of Captain America, who is a black woman named Samantha Wilson in this continuity.
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The Inexplicable Adventures of Bob!: While trying to manipulate Galatea, Riboflavin shapeshifts into his idea of what a male of her species would look like. Unfortunately, she doesn't actually have a species, and her reaction is, "Oh my G...! A sex-swapped version of my own face? I'll have nightmares for a week!" He then disguises himself as a handsome human male, and gets a much more favorable reaction from her.
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In the Starship Girl Yamamoto Yohko TV series, Yohko's male clone, Yousuke appears. He turns out to be female and in disguise, but then actually becomes male later.
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The Bridge: As a visual gag. Changelings can only mimic ponies of the same sex, so when a female one tries to mimic the transformed kaiju-to-unicorn Godzilla Junior the result is a female version of Junior.
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Sunsplit Saga: Basically the core idea of the saga, and a First-Episode Twist, Sunset Shimmer is Sunburst's magical construct clone, whom he made to take on a date.
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Dune Encyclopedia provides a history of all of Leto II's Duncan Idaho gholas, it includes that the Tleilaxu once provided a female Duncan Idaho ghola in a similar ploy to what the Ixians attempted with Hwi.
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In the Street Fighter series, Cammy is a female clone of M. Bison (Vega in Japan, or simply "Dictator" in international discussions), meant to serve as one of numerous backup vessels for him due to the inevitable Psycho Power-induced burnout of his body. Also a case of mix and match girl, given how she's basically an identical clone of the kidnapped Russian girl named Decapre, with some Bison thrown in for maximum Psycho Power containing capability.
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God-Emperor of Dune: Leto is introduced to Hwi Noree, the new Ixian Ambassador, who turns out to be an Opposite Sex Clone of the previous ambassador, genetically tweaked to be irresistible to the inhuman Leto.
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The Nightmare Before Christmas: Dr. Finklestein builds a female version of himself out of body parts around his lab. While not a genetic clone, he does give her a half of his brain.
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The Crusader Kings II mod Crisis of the Confederation, being a space opera mod, includes cloning as a possibility. Males cloning themselves can choose whether the clone will be male or female (females can only make female clones, though).
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InterWorld: Joseph Harker, after accidentally traveling between dimensions for the first time, realizes that he has been replaced in this dimension by Josephine Harker, an almost-exact female copy of himself.
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Star Trek: The Next Generation: When a non-corporeal entity impregnates Troi in "The Child", the baby is half-Betazoid and half-human, just like its mother in every way, except male.
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The following is a list of statements referring to the current page from other pages.

 Opposite-Sex Clone
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Gender-Blending Tropes
 Opposite-Sex Clone
processingCategory2
Our Clones Are Identical
 Opposite-Sex Clone
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Speculative Fiction Tropes
 Opposite-Sex Clone
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Monster Island Buddies (Web Video)
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Opposite-Sex Clone
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Opposite-Sex Clone
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