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Professor Guinea Pig

 Professor Guinea Pig
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Professor Guinea Pig
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So you're a bona fide scientific genius, and you've come up with a wonder drug that will allow people to live forever. So now you'll apply for approval from the FDA, right? Begin animal testing, assessing major organ toxicity in rats and small primates, then monitoring the subjects for carcinogenic effects and reproductive complications; who knows, if the drug behaves as predicted you could be doing Phase One clinical trials inside of five years.
Or, you could just mix up a batch of the stuff in your basement and drink it...
That's just what scientists do in fiction. They might go as far as trying out their incredibly experimental drug/strength ray/time-altering device/etc. on a squirrel or something first, but the point is that they move onto human testing quickly, usually without any safeguards or anyone observing, and they use themselves as a test subject. They might have their reasoning — they needed to get it done quickly because the invention is needed for some time-sensitive purpose (e.g., a dying loved one, a company about to go under); the story's setting (such as After the End) inherently limits the options in terms of test subjects; they're a discredited scientist, forced to work under the radar; the invention is being created not for public consumption but for the scientist's own (usually evil) ends; or the scientist is just plain crazy. But none of those are decent reasons, save possibly the insanity; it's just a dumbass thing to do. Hence the fact that half the time something Goes Horribly Wrong; and for the other half (which is far worse) something Goes Horribly Right.
On the other hand, these characters usually retain the audience's sympathy since they are risking only their own lives, not those of some poor Innocent Bystanders or their own children. This puts them in favorable contrast to the Obviously Evil Mad Scientists, who test their Phlebotinum on any innocent humans they can strap down to the table.
Testing things on themselves is actually terrible scientific procedure. Since the scientist has pre-conceived notions on what might happen, the results are unreliable and are likely to be discarded. There's also the issue that there can't be a control group due to the testee/tester knowing what they are doing. Many experiments don't tell the testees what they are trying to find out or lie to them in order to find out something different from what the scientists are claiming to find.
The more cartoonish the show, and the crazier the scientist, the more blatant this trope becomes. A Zany Cartoon might very well feature a scientist who, suddenly needing to be giant, just steps over to his array of beakers and retorts, mixes a bunch of funny-colored liquids together, and drinks it.
Believe it or not, this was actually standard procedure in many fields of science. Even as late as the 1950's, chemists would create a new compound and ingest it to see what it did. It was not the healthiest of occupations; quite a few scientists did end up killing themselves via experimentation. The Nuremberg Code of 1946, which codified the ethical requirements for human experimentation, forbids any experiment that is highly likely to or will certainly cause death or serious harm to the subjects. However, the ban is explicitly waived if the researcher is experimenting on themself. It still happens; see the real-life example section.
See also Guinea Pig Family and No Control Group. May overlap with Self-Made Superpowers, if the purpose (and result) of the experiment was the character gaining superpowers. May also overlap with Getting Sick Deliberately, if the character decides to test something by getting themselves ill first.
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2024-04-12T10:44:45Z
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Mocked in Mary Shelley's Frankenhole when Victor tells Doctor Jekyll that only an idiot would use himself as the test subject for an untested formula.
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For Bondrewd in Made in Abyss, everyone and everything is fair game for his experiments, he himself is no exception.
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The Far Side has a comic with a group of deformed scientists crowding around a non-deformed one, offering him a beaker full of noxious-looking bubbling liquid. Caption: "Laboratory peer pressure."
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In The Swarm (1978), Dr. Walter Krim tests out a killer bee anti-venom on himself. It goes as well as one might expect, and he's dead in minutes.
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Kiriko resorts to this with the last vaccine in 20th Century Boys, since she is in a hurry and no longer has as many resources as before.
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In The Transformers Megaseries, the Decepticon scientist Thunderwing used himself as a test subject for his experimental "polydermal grafting" technology. The experiments made him into a nigh-invulnerable and completely insane Person of Mass Destruction whose subsequent rampage forced the Autobots and Decepticons to unite against him. And the fight caused the destruction of Cybertron, which was the very thing he was trying to prevent.
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In X-Men, this is the origin of the original blue fuzzy status of Beast. In the X-Spider-Man crossover novel trilogy Time's Arrow, a future scientist hangs a lampshade on Beast's testing an experimental serum by drinking it. McCoy has the grace to be embarrassed. His original intention was to use it as a means of disguise which he could use to spy for his employer, one which he would reverse when his spying was done. (Yes, in those days Hank had a little problem with ethics.) However, it is true that Hank drinking the serum was a rather dumbass move to make, and Beast even lampshades this himself, when he observes that he didn't have to drink it — keeping it out of his employer's hands aside, it was in the end an act of hubris. Incidentally, this habit went horribly wrong in the Elseworld Mutant X — one of his projects significantly damaged his intelligence, and he's no longer smart enough to undo the effects.
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Buckaroo Banzai in The Adventures of Buckaroo Banzai Across the 8th Dimension, in a way. He decides to test his Oscillation Overthruster (which can allow something to pass through solid matter) in a vehicle he himself drives. He suffers no ill effects as a direct result, although the president's adviser suggests otherwise.
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Bleach:
Kurotsuchi Mayuri is obviously his own favorite test subject (he's given himself such bizarre abilities as being able to rip out his own ear and transform it into a kusarigama, and to launch his right arm as a grappling hook)... although based on what is known of his personality, most of his "improvements" were probably perfected on the unwilling first.
Mayuri's predecessor as the chief scientist of the Gotei 13, Urahara Kisuke, has also been known to do this. He invented a device that allows a Shinigami to achieve bankai (the final stage of their zanpakuto), which normally takes decades if not centuries, in no more than three days. "No more" because if bankai isn't achieved within that time, the user of the device will die. Urahara immediately used it himself.
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In The Time Machine, the Time-Traveller at least has the presence of mind to build a proof-of-concept device first.
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Purah from The Legend of Zelda: Breath of the Wild developed a Fountain of Youth rune with Ancient Sheikah technology so that the elderly warriors of Hyrule could once again be robust enough to fight Ganon's forces. She tested it on herself and quickly went from elderly to physically six years old. Naturally, she didn't bring it into mass use after that. Tears of the Kingdom has her do it again, this time with an aging rune to cure the previous, and it works, bringing her back into her prime.
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In the Star Trek: Enterprise episode "Daedalus", Emory Erickson, the wheelchair-bound inventor of the transporter, is shown receiving an injection from his daughter— his back and spine are grossly distorted, implying a failed transporter experiment.
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In Helix, Doctor Hiroshi Hatake hides glowing, silver irises behind brown-tinted contacts, suggesting some interesting side projects apart from the unregulated viral research Arctic Biosystems is conducting.
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House: Although Dr. House didn't create the drug, he did test one created by his old college rival to combat migraines. He decides to become a sort of drug pincushion: first, using nitroglycerin to give himself a stonking great headache, then trying the drug (which failed), then ridding himself of it using LSD, and finally anti-depressants to counteract the LSD... and the six Vicodin he had probably already taken that day. House probably had enough drugs in his system to mildly discomfort Keith Richards.
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In V: The Final Battle, the dust used to kill the Visitors is tested on an alien prisoner. Then while the others are busy arguing about whether they should find a human collaborator to test it on, the scientist steps into the chamber instead and survives.
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Marine biologist Dr. Lemuel Dorcas from Sub-Mariner was crushed when a machine toppled onto him during a fight against Namor, and to heal himself, he injected himself with regenerative starfish tissue. It mutated him into a human/starfish hybrid.
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In Avengers: The Initiative, Komodo was a paraplegic who understudied with Curt, above. You can probably see where this is going... she modifies the formula to regrow her legs and gets lizard-woman powers. On the plus side, she doesn't suffer Curt's split-personality issues, but only because she was at least smart enough to make sure that wouldn't happen. She also doesn't particularly care about being a lizard person because, hey, legs!
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The MythBusters often use themselves as test subjects for their experiments. That said, the experiments they run in this manner have to be approved by their insurance company in advance, and there's always someone keeping tabs on the test subject(s) (if not another one of the hosts, then a producer or other member of the production team), avoiding at least some of the pitfalls of this trope.
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Lampshaded in Blue Beetle. When Dani Garrett (having recently switched meds) decides to fly Jaime and herself into a volcano the following exchange occurs:
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In the third season premiere of Heroes, Mohinder Suresh takes a syringe of Maya's blood/DNA/super-powered-phlebotinum out onto a dock all by himself and injects it into himself. He gets insect-like super-strength, agility, and wall-climbing ability, but as a side effect appears to be mutating uncontrollably. The entire plotline appears to be a direct reference to The Fly (1986).
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Back to the Future is a rare example where the scientist doesn't test the machine himself, but he does put his beloved pet dog in the driver's seat, and himself and his best friend in the path of the speeding vehicle, so he does still seem overly confident. "If my calculations are correct, when this baby hits 88 miles per hour, you're gonna see some serious shit." "WHAT DID I TELL YOU?! EIGHTY-EIGHT MILES PER HOUR!" He did intend for himself to be the first human test subject, with the space of time to observe negative side effects in said dog being a few minutes.
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In the Justice League story "Injustice for All", Batman wrangles this sort of confession out of Cheetah while a "captive" of the Injustice Gang. She was desperate and didn't have the funding to conduct controlled experiments, so...
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In one episode of Grey's Anatomy, a patient is an immunologist who's conducting a long-term experiment on himself where he ingested parasitic worms to test if they'd help reduce his allergy symptoms. This isn't as crazy as it sounds. A real-life biologist infected himself and several volunteers with hookworms (not the same type of worm as in the show) to do the same thing, and the results are promising.
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This happens in several episodes of The Outer Limits (1995). "Double Helix" lampshades it.
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In the Another Code games, Richard ends up having the Another machine tested on himself twice — both times, it was done involuntarily by the villains.
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One of the enemies of Darkwing Duck did this: Reginald Bushroot, Ph. D. finds his funding cut. He tries his experimental procedure on a duck and ends up with a mutant plant-duck. The duck is, of course, himself. Once the science lab bullies ridicule him in front of the girl of his dreams, then the body count starts.
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In an episode of Star Trek: Discovery, science officer Paul Stamets uses a tardigrade-like creature as a navigation tool for the experimental spore drive, which allows instantaneous jumps across dozens of light-years. However, each jump takes a physical toll on the creature, and it eventually goes into self-induced hibernation. Burnham, Stamets, and Tilly figure out that the "tardigrade" is able to absorb the DNA of other living beings, thus explaining its symbiotic relationship with the spores. Burnham also realizes that humans still have a genetic link to the spores, since both are terrestrial species. For the final jump, Stamets injects himself with the creature's DNA and enters the reaction cube in order to use himself to plot the jump coordinates. It works, although Stamets is unconscious for several minutes. He personally finds the experience incredible. The last scene of the episode is a Wham Shot of Stamets turning away from his bathroom mirror to go to bed, while his reflection doesn't move for several seconds, before copying the action.
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In the Community episode "Social Psychology", Prof. Duncan inadvertently becomes the subject of the Duncan Principle.
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DC Animated Universe:
The first episode of Batman: The Animated Series, "On Leather Wings", involves a professor who drank serum with bat DNA and became the Man-Bat.
In the Justice League story "Injustice for All", Batman wrangles this sort of confession out of Cheetah while a "captive" of the Injustice Gang. She was desperate and didn't have the funding to conduct controlled experiments, so...
The villain of the Batman Beyond episode "Splicers" is Dr. Able Cuvier, the inventor of modern splicing technology — and like his forerunners above, he used himself as the first test subject. Funnily enough, while Cuvier's splicing is easily reversible and completely painless, he's the only one of these guys to be Hoist by His Own Petard.
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Dr. Michael Morbius tries to cure his blood disease by injecting himself with fluids distilled from vampire bats and turns himself into a living vampire in the process.
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Skylanders: Pop Fizz is a crazed alchemist who drinks the potions he creates (which he seemingly is unaware of the effects of), which has caused various changes to his body, the most notable of which is turning him into a maniacal monster.
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Harry Potter: Fred and George test sweets they've made that will cause sudden minor illnesses, allowing you to get out of class, on themselves. After they tried out the Nosebleed Nougat, their mother thought they'd had a fight. The worst it gets, though, is painful boils in an area they "don't normally expose to the public", and even that's eventually fixed. They try to test the sweets out on their fellow students (namely, first-years who wouldn't know to be suspicious), but Hermione stops them by threatening to tell their mother about it.
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The 100 Girlfriends Who Really, Really, Really, Really, Really Love You: The Yakuzens routinely test experimental drugs on themselves. Of particular note is Kusuri's immortality drug, which de-aged everyone in her family into eight-year-olds, with their Magic Antidote only countering it temporarily. (Or not at all in the case of her grandmother, for whom Kusuri sought to make the immortality drug in the first place.) Among the side effects of this practice is the Yakuzens being Unaffected by Spice and having Acquired Poison Immunity.
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Before I Hang: Using the blood of a recently executed prisoner, Dr. Garth and Dr. Howard succeed in developing a serum that will reverse the effects of aging and decide to test it on Dr. Garth immediately prior to his execution.
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SCP Foundation: Researchers in the Foundation often test their artefacts of their own accord, although they prefer to leave the more dangerous ones to the expendable "D Class" prisoners.
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Whateley Universe: A recurring problem with the devisers and gadgeteers of Whateley Academy (and out of it too, if Dr Venus and Lady Havoc are any indication). Hazmat was lucky; all his treatment did was burn all his hair off his head. Compiler wasn't quite so fortunate — while she did manage to become a faux-Exemplar and speedster through her nanite treatment, she ended up locked in her dorm room most of the time because she couldn't control her new powers. As for Migraine... well, she should have known better than to mix two different devisor projects when she wasn't even a Devisor herself. Then there are the Mad Scientist types like Jobe, who uses other students as his guinea pigs. Sometimes he even tells them this ahead of time. Sometimes.
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In Charite, Robert Koch tests Tuberculin, his experimental medicament that's supposed to heal tuberculosis, on himself. It's causing him a dangerous bout of fever. Truth in Television, by the way — the historical Robert Koch did just that.
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Professor Guinea Pig
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The Apothecary Diaries: The protagonist, Maomao, considers her own left forearm to be a perfectly acceptable testing site for poisons and medicines. She is also extremely casual about ingesting both to see what they do. Her Acquired Poison Immunity is the result of this habit.
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Professor Hojo in Final Fantasy VII. When the player party (some of its members being his former test subjects) finally confronts him, he injects himself with The Virus, claiming that he has, once more, succumbed to his desire for knowledge. As you'd expect from the dad of the Trope Namer, he pulls a One-Winged Angel afterward.
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In The Adventures of Dr. McNinja, Dr. Birding tested his formula to transform into a super-strong giant on himself, with dubious success. While it does accomplish this, it doesn't cure his paralysis, which was presumably the purpose behind the experiment.
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In an episode of Supergirl (2015), a Mad Scientist breaks Livewire out of prison only to plug her into his machine and drain her Shock and Awe powers into his two Mooks (a security guard and a former female prisoner). The two new Livewires turn out to be highly effective copies of the original. When the Guardian and Mon-El manage to defeat them at the scientist's warehouse, he references this trope before subduing them with a more powerful version of Livewire's lightning coming from his hands. Luckily, Supergirl arrives and, together with the original Livewire, defeats the scientist.
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Beast again, this time in X-Men: First Class... but he deserves a special mention because unlike a lot of scientists who then stop, X-Men: Days of Future Past makes clear that he kept doing it.
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Professor Guinea Pig / int_4f46b380
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Professor Guinea Pig
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Shirogane Ryou of Tokyo Mew Mew, upon completing his father's research, promptly tested it on himself. Because he conveniently didn't have the right genetic code, he did not, in fact, become a magical girl... er, boy.
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Daybreakers: Edward Dalton tests sun exposure plus submergence in water as a cure for vampirism. On himself. Justified in that he's the only vampire around the human refugee hideout when he tests it. Generally, unless there are vampire animals around, it's rather difficult to test a cure for vampirism in a method that is not either really stupid (this trope) or morally questionable (Strapped to an Operating Table).
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Ultimate Marvel:
In Ultimate Origins, Bruce Banner tries the Super-Soldier serum on himself. As you probably suspected, it goes horribly wrong. Later, in The Ultimates, Bruce decides to tinker with the formula a little while in a depressive funk and having heard Henry Pym insulting him. The end result: the Hulk, but stronger than before, and with the little extra detail that whatever Bruce's done is permanent this time.
Decades before, Bruce's mentor tried his own version of the Hulk serum out on himself. It actually worked for him. Then he ran off into the night to play crime lord with his new superpowers.
The Ultimates: Henry Pym tried the Giant-Man experiment on himself. It was a successful case, but still, he was the leading scientist, and many things could have gone wrong.
Ultimate Spider-Man: Having seen what his Oz formula did for scrawny Peter Parker, Norman Osborn decides that it's a terrifically great idea to inject himself with a souped-up version. The initial power-up blows up the lab, kills a lot of people, and shatters Norman's mind. Later on in the series, when the truth about Norman gets out, a lot of characters even point out how spectacularly dumb this was.
Ultimate Vision: Tarleton experimented on himself, even before the Gah Lak Tus unit showed up.
Ultimate X Men: Cornelius experimented on himself with Wolverine's DNA, and mutated himself.
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How Green Shield from DC Nation acquired meta-human abilities; faced with a terminal illness, she experimented on herself, hoping to turn her body into a "smoking gun" to protect her patent on the work and provide for her family. It instead made her extra tough, extra strong, arrested her illness's progression... and made her a fugitive from bosses Playing with Syringes.
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Attempted in Speed Grapher; however, since the "experiment" involved raping a 15-year-old girl, all for the better that it wasn't carried out.
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Professor Guinea Pig / int_57430640
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Professor Guinea Pig
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Resident Evil:
Scientist William Birkin from Resident Evil 2 injects himself with his experimental monster-making formula, which not only mutates him into an unrecognizable, gigantic, grotesque monster — but also drives him to impregnate his 10-year-old daughter. He had a better excuse than most, mind you — Umbrella goons had just repeatedly shot him in the chest. Injecting the serum was a last-ditch attempt to keep himself alive/fuck those goons over. The resulting abomination was mostly, if not entirely mindless aside from its considerable killing expertise.
Alexia Ashford from Resident Evil – Code: Veronica did the same thing, though only because she'd already messed around with her father and needed a new subject.
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Professor Guinea Pig / int_57ad0c07
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The Invisible Man: Griffin did test his process on a cat first, and he did have the excuse that he was kind of crazy. The justification given is that the invisibility process will only work on an albino — which Griffin is.
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Professor Guinea Pig / int_5a2f53d1
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Professor Guinea Pig
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Warframe:
Grineer scientist Tyl Regor is noted to have experimented on himself to the point that, unlike most other Grineer, he's able to speak English very clearly. He also proves to be Wicked Cultured and a Genius Bruiser.
The Veilbreaker update introduces former Corpus-turned-Solaris worker Chipper, who is noted to be quite experienced in modifications, including to himself (and considering that part of being a Solaris is the removal of one's organic limbs and head...).
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The Operator in Duumvirate developed a retrovirus to bestow transhumanity on whoever received it, and injected himself with it the second it was done synthesizing.
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In Soul Eater, one of the first things we learn about Franken Stein is that he is interested in observation and experimentation, where anything or one could be a test subject — including himself. Stein has, naturally, a bolt through his head and scars all over him. Sort of an odd example though in that we don't actually know what he did to himself. Yes, he has a stitch over his face but aside from that, he doesn't look too different from his younger incarnation we see in flashbacks so it at least wasn't anything cosmetic. He's been hailed as a genius meister since before he had the scar and bolt too so it wasn't some kind of power augmentation. So far the bolt and scar on his face only seem to be evidence that he has done this, but the reason behind it has not yet been given.
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Spider-Man: Norman Osborn's company is about to lose a military contract and go under, thanks to a lack of successful human trials of a performance-enhancing drug. With only two weeks to produce good results for the asshole general who makes the ultimatum and no time to go "back to formula" as suggested by his colleague, he tests it on himself in desperation — never mind the fact that, if that test were made public, he'd surely lose the contract and the company. It's all kind of moot anyway, as the drug does work...and makes him go insane as well.
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Scientist William Birkin from Resident Evil 2 injects himself with his experimental monster-making formula, which not only mutates him into an unrecognizable, gigantic, grotesque monster — but also drives him to impregnate his 10-year-old daughter. He had a better excuse than most, mind you — Umbrella goons had just repeatedly shot him in the chest. Injecting the serum was a last-ditch attempt to keep himself alive/fuck those goons over. The resulting abomination was mostly, if not entirely mindless aside from its considerable killing expertise.
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S.S.D.D. has Dr. Ashmore. He was working on new eye implants, and paperwork on live test subjects was slow. He'd test it on himself, but he had two healthy eyes...
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The Incredible Hulk (1977): David "Bruce" Banner is performing experiments on himself to try to "tap into the hidden strengths that all humans have." An accidental overdose of gamma radiation interacts with his body chemistry to change him: whenever he gets angry, he becomes the Hulk.
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In Star Trek: First Contact, Zefram Cochrane, the inventor of warp drive, flies the test ship himself. Given the post-apocalyptic setting, however, finding a trained pilot may have been very difficult, and it makes a certain amount of sense for the person who knows the ship inside and out to be aboard. At least he has two astronauts from the future to help him out.
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Testing your own inventions on yourself is the fast track to instant super-villainy in the Marvel Universe.
Dr. Curt Connors from Spider-Man tries using reptilian DNA to regrow his lost arm. Congratulations, Curt, now you're a violent half-human half-lizard monster. Bravo.
In Avengers: The Initiative, Komodo was a paraplegic who understudied with Curt, above. You can probably see where this is going... she modifies the formula to regrow her legs and gets lizard-woman powers. On the plus side, she doesn't suffer Curt's split-personality issues, but only because she was at least smart enough to make sure that wouldn't happen. She also doesn't particularly care about being a lizard person because, hey, legs!
Dr. Michael Morbius tries to cure his blood disease by injecting himself with fluids distilled from vampire bats and turns himself into a living vampire in the process.
Marine biologist Dr. Lemuel Dorcas from Sub-Mariner was crushed when a machine toppled onto him during a fight against Namor, and to heal himself, he injected himself with regenerative starfish tissue. It mutated him into a human/starfish hybrid.
In the universe of Marvel 1602, Baron Octavius suffered from the bubonic plague. He tried to cure himself by using the blood of octopuses. It worked, but also slowly transformed him into a human/octopus hybrid.
In X-Men, this is the origin of the original blue fuzzy status of Beast. In the X-Spider-Man crossover novel trilogy Time's Arrow, a future scientist hangs a lampshade on Beast's testing an experimental serum by drinking it. McCoy has the grace to be embarrassed. His original intention was to use it as a means of disguise which he could use to spy for his employer, one which he would reverse when his spying was done. (Yes, in those days Hank had a little problem with ethics.) However, it is true that Hank drinking the serum was a rather dumbass move to make, and Beast even lampshades this himself, when he observes that he didn't have to drink it — keeping it out of his employer's hands aside, it was in the end an act of hubris. Incidentally, this habit went horribly wrong in the Elseworld Mutant X — one of his projects significantly damaged his intelligence, and he's no longer smart enough to undo the effects.
Marvel's other noteworthy Hank, Hank Pym, was also an example of this, testing a shrinking serum on himself. After encountering some now-giant ants and managing to return to normal size, he originally planned to destroy the serum but later used it to become a superhero with varying levels of success. He did it again when he tested out his mind uploading technology to make a robot he named Ultron — who then went mad and became one of The Avengers' worst enemies. He's not proud of it.
Ultimate Marvel:
In Ultimate Origins, Bruce Banner tries the Super-Soldier serum on himself. As you probably suspected, it goes horribly wrong. Later, in The Ultimates, Bruce decides to tinker with the formula a little while in a depressive funk and having heard Henry Pym insulting him. The end result: the Hulk, but stronger than before, and with the little extra detail that whatever Bruce's done is permanent this time.
Decades before, Bruce's mentor tried his own version of the Hulk serum out on himself. It actually worked for him. Then he ran off into the night to play crime lord with his new superpowers.
The Ultimates: Henry Pym tried the Giant-Man experiment on himself. It was a successful case, but still, he was the leading scientist, and many things could have gone wrong.
Ultimate Spider-Man: Having seen what his Oz formula did for scrawny Peter Parker, Norman Osborn decides that it's a terrifically great idea to inject himself with a souped-up version. The initial power-up blows up the lab, kills a lot of people, and shatters Norman's mind. Later on in the series, when the truth about Norman gets out, a lot of characters even point out how spectacularly dumb this was.
Ultimate Vision: Tarleton experimented on himself, even before the Gah Lak Tus unit showed up.
Ultimate X Men: Cornelius experimented on himself with Wolverine's DNA, and mutated himself.
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Ultimate Vision: Tarleton experimented on himself, even before the Gah Lak Tus unit showed up.
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CinemaSins frequently adds a sin for this.
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In A Study in Scarlet, Watson's friend Stamford explains Sherlock Holmes' willingness to go this route. Barely a page or two later, Holmes happily and unconcernedly stabs himself in the finger to produce the fresh blood he required for a chemical test. Although he does at least put a sticking plaster over the cut, "'for I dabble in poisons a good deal.' He held out his hand as he spoke, and I noticed that it was all mottled over with similar pieces of plaster, and discoloured with strong acids."
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Equestria Girls: Friendship Souls: Grogar seeks to improve the Hollow condition (and mostly himself), and as such isn't afraid to use his research to augment his own body after having perfected it on the unwilling test subjects in his "care". In addition to the copy of Adagio's siren gem, his Resurreccion is a horrible mish-mash of his own flesh and cybernetic components made from reishi that in addition to strengthening his physical abilities allows him to use the powers of other Hollows and even Espada he's studied and replicated.
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"The Bicentennial Man": When Andrew invents new sorts of prosthetics, he is doing it to make a more human-like body for himself. He owns the patents but arranges for a leasing agreement with US Robots, provided they install the prosthetics into his body first. He's motivated to Become a Real Boy and making his body more organic in nature is part of that.
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The villain of the Batman Beyond episode "Splicers" is Dr. Able Cuvier, the inventor of modern splicing technology — and like his forerunners above, he used himself as the first test subject. Funnily enough, while Cuvier's splicing is easily reversible and completely painless, he's the only one of these guys to be Hoist by His Own Petard.
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Galaxy of Fear: City of the Dead has Dr. Evazam trying to make zombie soldiers, and it goes well for him, but he notices that the fresher the corpse, the smarter and more useful the zombie. Some still have their memories and can talk, so he tries killing random kids to quickly zombify. When this gets him killed, he comes back as a zombie with all his old memories and faculties — he had injected himself with the serum while still alive and is delighted to find that it worked so well.
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Overwatch features Moira; her intro cinematic and a couple of her sprays show her experimenting on herself.
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In Quantum Leap, Dr Sam Beckett was pressured to prove his theories or lose funding so he stepped into the project accelerator himself. This experiment wasn't exactly a resounding success.
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The Farscape episode "DNA Mad Scientist" has an inversion, a Mad Scientist who used to be a guinea pig, or an alien equivalent, before his intellect was enhanced and he killed most of his captors. He does perform further genetic modifications on himself, but he tests them on others first — for instance, injecting Aeryn with Pilot's DNA in order to isolate the Pilot species' multitasking ability.
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Wonder Woman (2017): Dr. Poison's facial scars are quite obviously caused by chemical burns, and Word of God confirms the implication that they were self-inflicted when Maru tested her corrosive gas on herself to see how effective it was.
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At the start of Frankenstein Created Woman, Baron Frankenstein is testing his theory that the soul does not leave the body at the moment of death by allowing himself to the buried for an hour, then frozen, and then revived by his assistant Dr. Hertz.
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Atlas Reactor:
Doctor Finn used himself as a subject in order to finalize his human-fish-hybridization procedure because he had run out of willing test subjects. Downplayed in that it's mentioned that he did test parts of the procedure on others first, but he was the first person to go through the finished process (which was performed by a whole team of geneticists and doctors).
Orion is a less benign example; he used the reactor merging technology that created him on himself first because he didn't want to risk anyone else becoming superpowered by it before he could. Having the procedure go horribly wrong, absorb his entire research group and the building they were in was a stroke of luck for him, really.
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Aaron Newt from +Anima performed many experiments regarding the titular +Anima phenomenon (children gaining animal superpowers after experiencing a near-death experience). He apparently performed a lot of these experiments on himself, which led to him becoming a strange-looking Beast Man.
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Archer:
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Semi-averted in an episode of The Saint, where a man with a heart condition wanted to use cryogenics until open-heart surgery was commonplace. He did several animal tests, and wanted to start human testing with somebody else, but at the end of the episode, Simon Templar escaped and a heart attack forced the man to enter his machine in an emergency.
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In BioShock 2, a Brute Splicer in the diner at Pauper's Drop turns out to have been Leo Hartwig, a scientist for Sinclair Solutions who put together a cocktail of strength- and speed-boosting plasmids and gene tonics and injected it into himself, turning him into one of the first Brutes. You find this out after listening to an audio log found on his corpse of him taking the serum and Hulking Out.
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Marvel's other noteworthy Hank, Hank Pym, was also an example of this, testing a shrinking serum on himself. After encountering some now-giant ants and managing to return to normal size, he originally planned to destroy the serum but later used it to become a superhero with varying levels of success. He did it again when he tested out his mind uploading technology to make a robot he named Ultron — who then went mad and became one of The Avengers' worst enemies. He's not proud of it.
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The Palaververse: Second Sun: "Starswirl's Partitioning Dweomerlayk"'s only seen casting applies its effects on the caster, and since Starswirl managed to make notes on its effects, that implies that he made those notes after testing it on himself.
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In Crying Suns, you can stumble upon an abandoned Akee space station where a Dr. Akara used herself as a test subject for her experiments. If you send some commandos to investigate the place, they will be slaughtered by a monstrous creature. If you then send in a fighting specialist to kill the beast, the specialist will identify it as Dr. Akara from its eyes.
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Batman: This is the origin of Batman's sometimes ally sometimes foe Man-Bat. Dr. Kirk Langstrom, a scientist specializing in the study of bats, develops an extract intended to give humans a bat's sonar sense and tests the formula on himself because he is becoming deaf. The extract works, but it has a horrible side effect: it transforms him into a hideous man-sized bat.
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I Was a Teenage Exocolonist: Sol gets at least two separate opportunities to be their own test subject:
If they assist Instance and Tangent with finding the Shimmer cure, one option they have is infecting themself with the disease, then trying the cure. In fact, in loops in which they know the cure works due to being a Groundhog Peggy Sue, but need to convince the colony's scientists, the option is encouraged.
If they come up with a new variety of blep tea while working in the xenobotany lab, their choice of testers are Tangent, Cal, or themself.
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Yatsubiyashi from Rebuild World, a Mad Scientist, installed his own cybernetic inventions in himself that give him Super-Strength and enough confidence to defend himself against hunters or monsters in the field.
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In the Boojumverse story "The Wreck of the Charles Dexter Ward", the villain injects herself with her experimental reanimation serum, believing that receiving it while still alive will produce better results than the mostly mindless zombies created by her previous tests.
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The Goodies: In "Snooze", Graham Garden invents a bedtime drink that works so well it puts the entire country to sleep. As there's no one else awake (except Tim who's chasing after a sleepwalking Bill), he has to test the antidote on himself.
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In If I Only Had A Heart, Izuku tests his own artificial prosthetics to replace his missing arm and eye as well as support his damaged spine on himself. Granted, he runs countless tests on non-living dummies beforehand, but he has neither the time nor the expenses to ask for a clinical trial, and his inventions are so advanced that no doctor would ever dare help him with it. He's also anywhere between 9 and 12 when he creates his own painkillers and performs surgery on himself. For the most part, they run smoothly, at least until he installs his artificial eye. That one gave him an epileptic seizure after his neural link to the supercomputer inside of it overwhelmed his brain, though he was up and at it after a short stay in the hospital.
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The Sparks of Girl Genius have a habit of "self-augmentation" just as much as experiments on other (often unwilling) patients.
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In the case of The Invisible Man, the title protagonist is the brother of the scientist who created the invisibility process, and there had been previous testing done, albeit not with very encouraging results. The protagonist agrees to undergo the treatment because the alternative is life in prison for a crime other than the one he actually committed. His brother also knew how to reverse the process... but didn't bother to tell anybody else or keep any records of it, so it became permanent when he was murdered. It later turns out that the records were stolen by Arnaud, Kevin's murderer. Arnaud then proceeded to repeat the experiment on himself, playing this trope straight.
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Dr. Cockroach from Monsters vs. Aliens was the result of a scientist testing a procedure to give humans the genetic hardiness of the common roach... and ending up with the head of one as well. For further fun, his PhD is in Dance!
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In Fullmetal Alchemist (2003), Shou Tucker experiments on his own body, becoming a monstrous canine chimera, in his attempts to resurrect his daughter Nina.
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Journey to Chaos: Ginger Hasina is a healer who makes experimental remedies. One of them was an anthrax vaccine that she tried on herself. When Eric enters her office late at night, she thinks auditory and visual hallucinations are side effects.
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Junior has Dr. Hesse test an experimental drug for reducing miscarriages on himself due to being unable to get funding and test subjects. He ends up pregnant.
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In Lost, it seems that Daniel Faraday tested his time machine on himself and only recovered from it gradually once near the Island. He also accidentally used it on his lab assistant/girlfriend, unsticking her in time.
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In Pokémon Red and Blue, the Pokémon researcher Bill, working on a Pokémon teleporter, has a Teleporter Accident, and combines himself with a Clefairy while working on it. Luckily for him, it's a fairly quick fix: the player just has to run the machine while he's inside so he can return to human form. Seems to be an homage to The Fly.
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In Shovel Knight, the Mini-Boss of Explodatorium is an alchemist who doesn't mind chugging down a potion to turn himself into a hulking beast. Or rummaging through shelves for said potion so violently bottles fly exploding everywhere, for that matter.
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In Ultimate Origins, Bruce Banner tries the Super-Soldier serum on himself. As you probably suspected, it goes horribly wrong. Later, in The Ultimates, Bruce decides to tinker with the formula a little while in a depressive funk and having heard Henry Pym insulting him. The end result: the Hulk, but stronger than before, and with the little extra detail that whatever Bruce's done is permanent this time.
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The first episode of Batman: The Animated Series, "On Leather Wings", involves a professor who drank serum with bat DNA and became the Man-Bat.
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In The Amazing Spider-Man, Dr. Connors is developing a serum to regrow limbs using "cross-species genetics". He logically goes through the process of computer simulations and then lab rats and concludes that it is ready for primate trials to determine long-term effects. His Corrupt Corporate Executive of a boss is the one who forces him to bypass his ethics by threatening to test it on unwitting veterans down at the VA if Connors doesn't comply. Cue Connors shooting himself up with lizard goo with predictable comic-book results.
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The Spectacular Spider-Man: As stated above, Dr. Curt Connors created a serum with lizard DNA that he believed would grow his arm back. It worked...and turned him into a giant lizard monster.
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The scientists in the Bio Research Lab in SaGa Frontier have used themselves as the testbeds for their experiments. They frequently crow about achieving "a disease-free, immortal body", but their tendency to transform into monsters speaks to the downsides of such a procedure. The Remastered version reinserts cut content from Asellus's story which reveals that they're experimenting on captured Mystics to gain the knowledge they then apply to themselves.
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In the first nationally broadcast season of Mystery Science Theater 3000, as well as the one that came before it, Dr. Laurence "Larry" Erhardt was an involuntary version: Dr. Forrester would test experiments on him (often against his will.) The more interesting ones included cold fusion being created within Erhardt's mouth and making him sweat through his tongue. TV's Frank would later take on this role, but not technically being a scientist he's just a plain Guinea Pig.
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Star Trek: The Original Series:
In "Miri", our heroes are trapped on a planet and slowly dying from a disease that kills all adults. Dr. McCoy has mixed up what may very well be the antidote. Only problem is, he's not sure, and the only way to be sure is to check the Enterprise's computers, which can't be done because the local Creepy Children have stolen the communicators. What to do? Why, wait until Spock leaves and inject yourself, of course!
Cited in "Dagger of the Mind" to explain why a researcher from a penal colony has escaped onto the Enterprise, raving mad and terrified of returning. Apparently, he was testing a "neural neutralizer" on himself at too high a setting. However, Dr McCoy doesn't buy this and insists that Captain Kirk investigate. Turns out the neural neutralizer is being used for forced brainwashing.
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Ultimate Spider-Man: Having seen what his Oz formula did for scrawny Peter Parker, Norman Osborn decides that it's a terrifically great idea to inject himself with a souped-up version. The initial power-up blows up the lab, kills a lot of people, and shatters Norman's mind. Later on in the series, when the truth about Norman gets out, a lot of characters even point out how spectacularly dumb this was.
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20,000 Leagues Under the Sea: In a variation, The Professor Aronnax is willing to sacrifice his own freedom for the rest of his life for the rare chance to discover all the sea’s secrets in the Nautilus. Fortunately, he is not willing to sacrifice his friend’s freedom and leads them in their Great Escape.
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The Fourteenth Goldfish: Melvin tested the serum he developed with an extract of his T. Melvinus jellyfish on himself, and as a result, he has the body of a 13-year-old, when he's actually 75.
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Alexia Ashford from Resident Evil – Code: Veronica did the same thing, though only because she'd already messed around with her father and needed a new subject.
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In The Story of Louis Pasteur, Charbonnet the skeptic injects himself with Pasteur's rabies culture to prove that Pasteur's theories about germs causing disease are wrong. Charbonnet is triumphant when he never gets sick, but this leads Pasteur to an "Eureka!" Moment in which he figures out that weakened forms of the germ (the sample was three weeks old) can be used in vaccines to combat illness.
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SilverFin: Since he was running out of test subjects back in the States, Algar Hellebore tried the eponymous Super-Soldier serum on himself. As a result, he has become a hulkish but kind brute with little sign of his previous intelligence.
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Ultimate X Men: Cornelius experimented on himself with Wolverine's DNA, and mutated himself.
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In Noah Smith's stage version of The Strange Case of Dr. Jekyll and Mr. Hyde, Jekyll does at least spend several months testing his serum on animals before considering human testing, but he's his own first and only human test subject.
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Magic: The Gathering: In the Innistrad and Shadows over Innistrad blocks, there’s a cycle of two-faced cards (Delver of Secrets and Insectile Aberration, Aberrant Researcher and Perfected Form, and finally Docent of Perfection and Final Iteration) that follows a Mad Scientist as he runs tests on himself after running out of other subjects and turns himself into an insectoid monster, eventually putting himself through increasingly complex processes to "perfect" his form and turn into more and more horrible forms, eventually returning to share his discoveries with the other humans once he’s satisfied with his transformations. The final card reveals why he's transformed so horrifically: he's unknowingly tapped into the power of the Eldrazi.
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Portal 2 reveals that Cave Johnson, the lunatic founder of Aperture Science, was not above testing his inventions on himself. This resulted in his death by Conversion Gel (moon dust) poisoning. Somewhat related, when his recruitment of street bums as test subjects had less than ideal results, he began encouraging his own employees to test the company's products, which had a negative effect on morale and retention. The next evolution of this seems to have occurred only after his death, with "Bring Your Daughter to Work Day".
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Darkest Dungeon: The Hag was once an ordinary young woman with a strong interest in medicine and herbology, who helped the Ancestor with his research. However, her insistence on sampling various strange plants and fungi, and concoctions derived from them, turned her into a hideous, cannibalistic madwoman whom the Ancestor eventually banished to the depths of the Weald.
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Hakase from NEXT!!! Sound of the Future is one of the only doctors around willing to do voice modifications on androids (due to them being illegal), and they also happen to have a line of stitches around their throat heavily suggesting they've modified their own. Not to mention all the other stitches on their body, which seems to serve more than just an aesthetic purpose given that their hand is a different skin tone than the rest of them.
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Professor Brody in Cats & Dogs tests his allergy cures on himself. He does it three times that we can see in the movie: the first time, it doesn't work, and he breaks out in hives all over; the second time, his nose becomes bulbous but at least he doesn't sneeze; the third time, it's the correct cure.
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Dr. David Banner from Hulk resorted to using himself as a test subject for his Bio-Augmentation research after the Army refused to let him use human test subjects. As it turns out, the modifications are inheritable...
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In G.I. Joe: A Real American Hero (Marvel), a dentist tried to develop a new method of pain relief that he decided to test on himself. The resulting personality corruption turned him into the Cobra operative known as Dr. Mindbender.
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Dr. Curt Connors from Spider-Man tries using reptilian DNA to regrow his lost arm. Congratulations, Curt, now you're a violent half-human half-lizard monster. Bravo.
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Spider-Man: Turn Off the Dark sees Dr. Norman Osborn, bereft of funding for his experiments and against the objections of his wife, test his DNA-splicing equipment on himself. It turns him into the Green Goblin.
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Hollow Man and its sequel both have the person who has taken the serum become a serial killer. The original does have extensive animal testing of the invisibility serum, but the head scientist fudges the results and takes the serum himself. In this case, the big problem is reversing the invisibility process; the scientist thinks that trying it on a human will provide better results, and he's the only one willing to do it.
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Victor in Upldr used himself as a test subject on a way to upload and download information directly from the human brain.
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Warhammer 40,000 has Fabius Bile, a mad scientist sworn to Chaos who not only experiments on others but is also said to have used his own body as his most extensive testing ground.
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In El Goonish Shive, Tedd tends to test his transformation tech on himself.
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Subverted in Power Rangers: Dino Thunder where Dr. Anton Mercer tries and tries to perfect a potion to free himself from his Superpowered Evil Side Mesogog, where Mesogog actually succeeds in perfecting the potion and capturing the scientist. Of course, Mercer experimenting on himself was what created Mesogog in the first place.
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The crux of the plot of Flatliners is the students experimenting with near-death experiences on themselves after interviews with patients and their experiences.
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Stretch Armstrong and the Flex Fighters reveals the Big Bad Stretch Monster as the alter ego of a scientist who attempted to find a cure for all diseases, and injected an early sample into himself, while disregarding the other scientists' warnings not to test it on humans so soon.
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The members of the Val'Jaal'darya clan in Drowtales, specialists in bio-magical technology and experimentation, often use themselves for their experiments, such as outfitting themselves with Artificial Limbs — or even wings and tails — of real flesh. Their leader, Asira'malika, owes her dark-scleraed, white-irised eyes, and the bleached-looking skin around them, to a failed attempt at turning herself into a dark elf.
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Team Fortress 2:
The Medic apparently did this during the Halloween 2013 update, replacing his entire head with that of his pet dove, Archimedes. Exclusive lines for wearing the item reveal he isn't quite sure whether this is awesome, or whether he regrets it. Even earlier, though, he was implied to have performed open-heart surgery on himself so he could utilize the Ãœbercharge function he designed.
The Engineer (Dell Conagher) did this as well, testing out his new robotic hand design by willingly chopping one of his hands off. Of course, the Engineer was suffering from Australium exposure at the time, so at least he had an excuse.
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Doctor Who:
"The Lazarus Experiment": Elderly Professor Richard Lazarus uses himself as the test subject for his rejuvenation machine, which has some... interesting... side effects. "Mutation into a giant monster" side effects.
"Spyfall": Tech mogul Daniel Barton's DNA proves to be only 97% human when scanned. He eventually explains that the Kasaavin can convert human DNA into one of the most efficient data storage devices on Earth, and he's a "proof-of-concept".
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Bruce Banner supposedly did this in Child of the Storm, having seen the files on Camp Cathcart. The result was the Hulk. Sinister also got his powers this way.
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Dr. Muto has one as its protagonist, capable of collecting DNA from various creatures to mutate himself into various beasts.
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The Tingler: Dr. Warren Chapin is researching the physiological aspects of fear, and experiments on himself taking LSD some six years before the hippies appropriated it for their own.
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Done by Dr. Nitrus Brio in Crash Bandicoot (1996) at the end of the boss battle. Before that, he spends time throwing the beakers at you. The red beakers, properly mixed, become highly volatile, exploding when smashed, while the green ones release semi-alive brains that chase after you. Naturally drinking a mixture of both turns him into a giant green muscleman.
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One of the subjects of Hikawa's experiments in the Birdy the Mighty OVA series was himself, giving himself telekinesis and Super-Strength, as well as reverting him to his physical prime. He's also willing to ignore any side-effects of his experiments, including, again, to himself.
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Bugsnax: Floofty Fizzlebean can't convince any of the other grumpuses on Bugsnax Island to help with their bizarre and dangerous experiments, so they end up testing on themselves. This includes cutting off their own snakified leg (and eating it!) and then trying to regenerate it with an experimental device.
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The Crew of the Copper-Colored Cupids: It is revealed in Revenge of the Old Queen that Doctor Curious, amateur mad scientist and Crown Prince of Triskadeckia, experimented on himself and ended up accidentally mutating himself into a half-snake humanoid, forcing him to flee the palace in disgrace.
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In Sanctuary (2007), the Five all injected a serum based on pure vampire blood directly into their veins. The results were surprisingly beneficial. However, each one got different results, some of which were not related to vampiric abilities: Helen Magnus only got longevity out of it, John Druitt gained teleportation powers with Teleportation Sickness, Nigel Griffin became the Invisible Man, James Watson became a super-genius, and Nikola Tesla became a vampire with electricity powers.
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In the universe of Marvel 1602, Baron Octavius suffered from the bubonic plague. He tried to cure himself by using the blood of octopuses. It worked, but also slowly transformed him into a human/octopus hybrid.
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In The Butcher Bird, Grigori Vinci tests most of his Augment types on himself before giving them to others.
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In The Neanderthal Man, a Mad Scientist tests a devolution serum on himself in order to prove his theory that prehistoric man was more intelligent.
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Somewhat used in Pokémon: The Series: the Pokémon researcher Bill stuffs himself inside a Kabuto costume to find out what it feels like. See the video games section for the more on-the-spot version from the games.
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The Ultimates: Henry Pym tried the Giant-Man experiment on himself. It was a successful case, but still, he was the leading scientist, and many things could have gone wrong.
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In League of Legends, Singed, Mundo, and Heimerdinger are all scientists who have experimented on themselves, and as a result have gone terribly disfigured. Singed is now covered in burns and most of his body is wrapped up in bandages, but he has also been strengthened by self-testing. Mundo, although he used to be human, is now a giant, purple Frankensteinesque monster who talks in the third person. Heimerdinger, in the effort to become smarter, expanded his brain so much that now his entire head is shaped like one.
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Another classic example is The Strange Case of Dr. Jekyll and Mr. Hyde and all the variations thereof, e.g. The Nutty Professor (1963).
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In Casualty 1906, Anton Lesser's psychiatrist character asked another doctor to perform an operation on him in order that he could experience the emotions some of the hospital's patients were going through prior to an early 20th-century operation.
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In the third season of The 4400, Kevin Burkhoff has discovered promicin, the neurotransmitter that gives the returnees their abilities, and injects himself with it. First he gets all messed up (skin falling off, etc.), but eventually he develops his healing power.
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In Noblesse, this is the difference between the mostly evil Union, who got their data and progress by experimenting on countless innocents, and the mostly good Frankenstein, who did the same using only himself as a test subject.
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In Dr. Franklin's Island, this comes up when the titular doctor happily explains that he's going to splice his captives with animals, acting like it's a great adventure and even saying "If I had your young cells, but alas it's too late." In previous trials, splicing captive animals with human genes, initially much of the human material came from him and his assistant.
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Genius: The Transgression
The Progenitors have a whole transhumanist philosophy centered around this trope. They specialize in creating biological Wonders, as well as prosthetics and implants of various types. Originally, they experimented and tested their creations on human subjects of varying levels of willingness, but following the discovery of this by the rest of Genius society (and an ensuing internal purge of their old guard) they’ve taken to testing their creations and upgrades on their own selves instead.
The trope is also enforced by the game's Karma Meter: self-modification is a Transgression, but running risky and dangerous experiments on human test subjects (even willing ones) is a worse one.
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In Dead of Summer, Alan Stone is this, testing a 'cure' for zombiism on himself. When it fails, turning him into a monster, he uses it on his wife.
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At the end of Vessel, Arkwright decides to use the Accelerator on himself, believing that as the creator of the Fluros and indirectly responsible for the havoc they've caused, it's his duty to take the first step into the next phase of human evolution. He runs the machine with himself inside and becomes a Transhuman made from protoplasm.
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Paperinik New Adventures:
Gorthan is an Evronian scientist specializing in creating Super Soldiers who "improved himself", among others.
Xadhoom's immense power may or may not be the result of this. It's clear she was trying to create a powerful and eternal power source to stave off Xerba's impending energy crisis, and while some flashbacks have her implying that becoming such an energy source was a genuine accident the Evronian scientist Zoster openly states she did it on purpose (then again, Evronians don't have a good record understanding people with emotions).
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Over the course of her 71 years of life which became immortal at 15, Beatrix from Battleborn has constantly experimented on herself, a thing which she has no qualms about.
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In Dingo Doodles, Emperor Goddrick III has a grand plan to evolve the Foreclaimers into a higher form of being by stealing the sun's power. To prove his plan could work, he implanted himself with two power crystals, something Gothi says should be impossible.
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In The Fly (1958), the lead character tries teleporting himself and winds up switching heads with a housefly. The 1986 version of the story, besides having the experience result in a Slow Transformation into a Half-Human Hybrid instead, rationalizes this trope simply enough. While Seth has just finally sent a baboon through the process with no ill effects, after a previous attempt turned a creature inside-out, he plans to have the animal tested to make sure it's truly unaffected and is willing to wait weeks on that before making another move. Teleporting himself is supposed to be the Grand Finale of his work somewhere down the line. But due to a misunderstanding involving his love interest, who abruptly leaves to confront her editor/ex-lover just as they're celebrating the breakthrough of the baboon, Seth ends up getting drunk on champagne and decides to teleport himself right there and then.
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In Gears of War 3, Adam Fenix turns out to have injected himself with Imulsion in order to study how the Lambent infection spreads and build his Lambent-killing weapon accordingly, knowing full well that becoming infected would mean the weapon would kill him as well. Granted, it's not like there was anyone else around for him to experiment on instead.
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Implied in StarCraft II. If you choose to help Selendis for the "Safe Haven"/"Haven's Fall" mission, Dr. Ariel Hanson will swear to find a cure for the Zerg nanovirus before the heroes can destroy the colony. Partway through the mission, Captain Horner calls you, reporting that Dr. Hanson has locked herself in the lab. After the mission, Hanson is found to be suffering the effects of the Zerg nanovirus (major Body Horror and Nightmare Fuel involved), and she has to be killed before she can do any damage. Given that this doesn't happen if you choose to help Dr. Hanson by protecting the colony, it's implied that she injected herself not only with the supposed cure but with the nanovirus it's supposed to be effective against. That, or she had an accident brought on by her haste; either way, she locked herself in the lab to protect the rest of the crew.
 Professor Guinea Pig / int_eaeeea9b
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1.0
 Professor Guinea Pig / int_eaeeea9b
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1.0
 StarCraft II (Video Game)
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Professor Guinea Pig / int_eaeeea9b
 Professor Guinea Pig / int_ed5e07f2
type
Professor Guinea Pig
 Professor Guinea Pig / int_ed5e07f2
comment
In Other Life, founder Ren seems to be the only person the eponymous technology is ever tested on.
 Professor Guinea Pig / int_ed5e07f2
featureApplicability
1.0
 Professor Guinea Pig / int_ed5e07f2
featureConfidence
1.0
 OtherLife
hasFeature
Professor Guinea Pig / int_ed5e07f2
 Professor Guinea Pig / int_ee3a1919
type
Professor Guinea Pig
 Professor Guinea Pig / int_ee3a1919
comment
The Projected Man features a scientist who must quickly jury-rig a teleportation experiment to convince his Corrupt Corporate Executive sponsors not to cut his funding. Unfortunately, the ditsy blonde secretary he enlists to help him teleport botches the procedure, and the machine explodes. The scientist then winds up getting his DNA mixed with that of a rat that had died in a previous experiment. Oh, and he also gets the ability to generate lethal electric shocks.
 Professor Guinea Pig / int_ee3a1919
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1.0
 Professor Guinea Pig / int_ee3a1919
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1.0
 The Projected Man
hasFeature
Professor Guinea Pig / int_ee3a1919
 Professor Guinea Pig / int_ee8e40e4
type
Professor Guinea Pig
 Professor Guinea Pig / int_ee8e40e4
comment
The Adult Version of Jekyll and Hide: Leeder tested his experimental formula on himself.
 Professor Guinea Pig / int_ee8e40e4
featureApplicability
1.0
 Professor Guinea Pig / int_ee8e40e4
featureConfidence
1.0
 The Adult Version of Jekyll and Hide
hasFeature
Professor Guinea Pig / int_ee8e40e4
 Professor Guinea Pig / int_f1d71960
type
Professor Guinea Pig
 Professor Guinea Pig / int_f1d71960
comment
Machine Man has Dr. Charles Neumann. An engineer at Better Future, Neumann doesn't design any Artificial Limbs that he wouldn't try out himself.
 Professor Guinea Pig / int_f1d71960
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1.0
 Professor Guinea Pig / int_f1d71960
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1.0
 Machine Man
hasFeature
Professor Guinea Pig / int_f1d71960
 Professor Guinea Pig / int_f652eaf8
type
Professor Guinea Pig
 Professor Guinea Pig / int_f652eaf8
comment
Dr. Xavier of X: The Man with the X-Ray Eyes tests the X-Ray Vision eyedrops on himself... in both eyeballs.
 Professor Guinea Pig / int_f652eaf8
featureApplicability
1.0
 Professor Guinea Pig / int_f652eaf8
featureConfidence
1.0
 X: The Man with the X-Ray Eyes
hasFeature
Professor Guinea Pig / int_f652eaf8
 Professor Guinea Pig / int_f8956ef3
type
Professor Guinea Pig
 Professor Guinea Pig / int_f8956ef3
comment
Yu Kaitou in YuYu Hakusho has the power to steal the soul of anyone who breaks the "rules" he sets down for his psychic territory. If he breaks his own rules, then his soul is separated from his body. How did he find this out? Why, he breaks his own rules on purpose, of course, forcing his friends to seek out Genkai to find out how to cure him before it's too late, which causes the events that kick off the prologue to the Chapter Black Saga.
 Professor Guinea Pig / int_f8956ef3
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1.0
 Professor Guinea Pig / int_f8956ef3
featureConfidence
1.0
 YuYu Hakusho (Manga)
hasFeature
Professor Guinea Pig / int_f8956ef3
 Professor Guinea Pig / int_fcd2ef99
type
Professor Guinea Pig
 Professor Guinea Pig / int_fcd2ef99
comment
Sage from Castoff, a firm believer in Sufficiently Analyzed Magic and the closest the continent of Alveria has to a Mad Scientist, used to try out healing spells by cutting himself and casting the spells on the cut. He has lots of scars on his arms.
 Professor Guinea Pig / int_fcd2ef99
featureApplicability
1.0
 Professor Guinea Pig / int_fcd2ef99
featureConfidence
1.0
 Castoff (Webcomic)
hasFeature
Professor Guinea Pig / int_fcd2ef99

The following is a list of statements referring to the current page from other pages.

 Professor Guinea Pig
processingCategory2
Make My Index Live!
 Professor Guinea Pig
processingCategory2
Medical Horror
 Professor Guinea Pig
processingCategory2
Speculative Fiction Tropes
 Professor Guinea Pig
processingCategory2
Tropes on Science and Unscience
 Chuck Chicken (Animation) / int_442e3d95
type
Professor Guinea Pig
 G.I. Joe: A Real American Hero (Marvel) (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 Hack/Slash (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 Iceman (Marvel Comics) (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 Plasmer (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 Spirou & Fantasio (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 The Superman Adventures (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 The Transformers Megaseries (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 Ultimate Marvel (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 Ultimate Origins (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 Ultimate Vision (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 World of Krypton (Comic Book) / int_442e3d95
type
Professor Guinea Pig
 An Apple Sleep Experiment (Fanfic) / int_442e3d95
type
Professor Guinea Pig
 Cities in Dust (Fanfic) / int_442e3d95
type
Professor Guinea Pig
 Equestria Girls: Friendship Souls (Fanfic) / int_442e3d95
type
Professor Guinea Pig
 Null (Fanfic) / int_442e3d95
type
Professor Guinea Pig
 Spider-X (Fanfic) / int_442e3d95
type
Professor Guinea Pig
 The Great Alicorn Hunt (Fanfic) / int_442e3d95
type
Professor Guinea Pig
 Altered States / int_442e3d95
type
Professor Guinea Pig
 Amsterdam (2022) / int_442e3d95
type
Professor Guinea Pig
 Contagion (2011) / int_442e3d95
type
Professor Guinea Pig
 Daybreakers / int_442e3d95
type
Professor Guinea Pig
 Dr. Jekyll and Mr. Hyde (A'yoy) / int_442e3d95
type
Professor Guinea Pig
 Flatliners / int_442e3d95
type
Professor Guinea Pig
 Hollow Man / int_442e3d95
type
Professor Guinea Pig
 Hulk / int_442e3d95
type
Professor Guinea Pig
 I, Monster / int_442e3d95
type
Professor Guinea Pig
 Kingsajz / int_442e3d95
type
Professor Guinea Pig
 Living Proof / int_442e3d95
type
Professor Guinea Pig
 Pet (2016) / int_442e3d95
type
Professor Guinea Pig
 Polite Society / int_442e3d95
type
Professor Guinea Pig
 Re-Animator / int_442e3d95
type
Professor Guinea Pig
 Romance of Radium / int_442e3d95
type
Professor Guinea Pig
 Tarantula! / int_442e3d95
type
Professor Guinea Pig
 The Adult Version of Jekyll and Hide / int_442e3d95
type
Professor Guinea Pig
 The Amazing Bulk / int_442e3d95
type
Professor Guinea Pig
 The Amazing Spider-Man / int_442e3d95
type
Professor Guinea Pig
 The Fly (1958) / int_442e3d95
type
Professor Guinea Pig
 The Invisible Man (1933) / int_442e3d95
type
Professor Guinea Pig
 The Swarm / int_442e3d95
type
Professor Guinea Pig
 The Swarm (1978) / int_442e3d95
type
Professor Guinea Pig
 Upldr / int_442e3d95
type
Professor Guinea Pig
 X: The Man with the X-Ray Eyes / int_442e3d95
type
Professor Guinea Pig
 Dr. Franklin's Island / int_442e3d95
type
Professor Guinea Pig
 Elevator to Nowhere / int_442e3d95
type
Professor Guinea Pig
 Goosebumps HorrorLand / int_442e3d95
type
Professor Guinea Pig
 Harry Potter and the Order of the Phoenix / int_442e3d95
type
Professor Guinea Pig
 Machine Man / int_442e3d95
type
Professor Guinea Pig
 Orthogonal / int_442e3d95
type
Professor Guinea Pig
 Peter Benchley's Creature / int_442e3d95
type
Professor Guinea Pig
 Revelation Space Series / int_442e3d95
type
Professor Guinea Pig
 SilverFin
seeAlso
Professor Guinea Pig
 The Bicentennial Man / int_442e3d95
type
Professor Guinea Pig
 The Dark Profit Saga / int_442e3d95
type
Professor Guinea Pig
 The Fourteenth Goldfish / int_442e3d95
type
Professor Guinea Pig
 The Invisible Man / int_442e3d95
type
Professor Guinea Pig
 The Man Who Evolved / int_442e3d95
type
Professor Guinea Pig
 The Strange Case of Dr. Jekyll and Mr. Hyde
seeAlso
Professor Guinea Pig
 The Strange Case of Dr. Jekyll and Mr. Hyde / int_442e3d95
type
Professor Guinea Pig
 Think! / int_442e3d95
type
Professor Guinea Pig
 20,000 Leagues Under the Sea / int_442e3d95
type
Professor Guinea Pig
 Hourman
seeAlso
Professor Guinea Pig
 HumanTrialIsHumanError
seeAlso
Professor Guinea Pig
 JustImagineStanLeeCreatingTheDCUniverse
seeAlso
Professor Guinea Pig
 TheAvenger
seeAlso
Professor Guinea Pig
 Birdy the Mighty (Manga) / int_442e3d95
type
Professor Guinea Pig
 Cyborg 009 (Manga) / int_442e3d95
type
Professor Guinea Pig
 Golgo 13 (Manga) / int_442e3d95
type
Professor Guinea Pig
 ars PARADOXICA (Podcast) / int_442e3d95
type
Professor Guinea Pig
 SAYER (Podcast) / int_442e3d95
type
Professor Guinea Pig
 Charite / int_442e3d95
type
Professor Guinea Pig
 Curfew / int_442e3d95
type
Professor Guinea Pig
 Grimm / int_442e3d95
type
Professor Guinea Pig
 Helix / int_442e3d95
type
Professor Guinea Pig
 Hero Corp / int_442e3d95
type
Professor Guinea Pig
 Power Rangers: Dino Thunder / int_442e3d95
type
Professor Guinea Pig
 The Invisible Man / int_442e3d95
type
Professor Guinea Pig
 The Saint / int_442e3d95
type
Professor Guinea Pig
 The Time Tunnel / int_442e3d95
type
Professor Guinea Pig
 V (1983) / int_442e3d95
type
Professor Guinea Pig
 Deviant: The Renegades (Tabletop Game) / int_442e3d95
type
Professor Guinea Pig
 Genius: The Transgression (Tabletop Game) / int_442e3d95
type
Professor Guinea Pig
 Vampire: The Requiem (Tabletop Game) / int_442e3d95
type
Professor Guinea Pig
 Spider-Man: Turn Off the Dark (Theatre) / int_442e3d95
type
Professor Guinea Pig
 Atlas Reactor (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Chernobylite (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Darkspore (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Dr. Muto (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Final Fantasy IV (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Halo 4 (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Pokémon Red and Blue (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Portal 2 (Video Game) / int_442e3d95
type
Professor Guinea Pig
 The Thing (2002) (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Trepang2 (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Undercurrent (Video Game) / int_442e3d95
type
Professor Guinea Pig
 Zombie Night Terror (Video Game) / int_442e3d95
type
Professor Guinea Pig
 SuperThings (Web Animation) / int_442e3d95
type
Professor Guinea Pig
 Anacrine Complex (Webcomic) / int_442e3d95
type
Professor Guinea Pig
 Danger Zone One (Webcomic) / int_442e3d95
type
Professor Guinea Pig
 Juathuur (Webcomic) / int_442e3d95
type
Professor Guinea Pig
 Planet of Hats (Webcomic) / int_442e3d95
type
Professor Guinea Pig
 Badass of the Week (Website) / int_442e3d95
type
Professor Guinea Pig
 The Crew of the Copper-Colored Cupids (Website) / int_442e3d95
type
Professor Guinea Pig
 The RPG Cliches Game (Website) / int_442e3d95
type
Professor Guinea Pig
 Cloudy with a Chance of Meatballs / int_442e3d95
type
Professor Guinea Pig
 Help! I'm a Fish / int_442e3d95
type
Professor Guinea Pig
 Johnny Test / int_442e3d95
type
Professor Guinea Pig
 Mighty Max / int_442e3d95
type
Professor Guinea Pig
 Monsters vs. Aliens / int_442e3d95
type
Professor Guinea Pig
 Spider-Man: The Animated Series / int_442e3d95
type
Professor Guinea Pig
 The Spectacular Spider-Man / int_442e3d95
type
Professor Guinea Pig
 Both Syllables / Fan Fic / int_442e3d95
type
Professor Guinea Pig
 professorguineapig
sameAs
Professor Guinea Pig