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Scale of Scientific Sins

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In some fiction, science is a religion — an evil, godless religion that isn't just Bad and Wrong, but unethical by nature. And like all religions, it has sins — or, rather, "virtues". These are the sins that a Mad Scientist commits in his quests For Science!. If... no, when these are violated something will Go Horribly Wrong and the transgressor will receive karmic punishment in accordance to the sin, increasing in evil as the number rises. No exceptions.
Proud scientists will actively try to check off as many of these sins as they can as a proof of their scientific genius.
Automation.
Making something, anything, with potential applications.
2.1 Stimulating yourself.
2.2 Using powers for things other than combat.
Genetic Engineering and Transhumanism in general
3.1 When it's unwilling, but otherwise mostly human.
3.2 When it results in a Mix and Match Critter.
3.3 When Cybernetics Eat Your Soul.
Immortality when it doesn't revive the dead. (that's type 6)
Creating Life.
Cheating Death.
Usurping God.
Despite the name, magic often considers these sins as well, the kind of deeds magicians are capable of but must never do. Some of these are Older Than Steam, but modern authors often also rely on them to explain why Reed Richards Is Useless by demonizing potential applications for his technology or powers.
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And also in Terminator, particularly in the second and third movies.
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One of the major recurring themes in Shadow Hearts is a manuscript that can resurrect the dead, but it never turns out like intended.
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Volt from Choujuu Sentai Liveman is the villainous organization the Liveman fight against, and they're all over every sort of conceivable bad way to use science. The Big Bad especially, as all he really wants to do is use his minion's intelligence to make him younger.
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Our Fair City: This is seen in the second season when Dr. Herbert West, despite his amiable nature, releases a horde of zombies on Hartlife.
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Dragon Age: "The Chantry teaches us that it was the hubris of men the one that brought the Darkspawn into the world. The mages sought to usurp heaven, but instead they destroyed it." That's also an (attempted) type seven according to the Chantry, since the mages were trying to usurp The Maker.
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Frankenstein — though debatable, since the Monster was created as a blank slate in the book. Although Frankenstein itself may not fully apply, the story did go on to spawn dozens of B movies that featured Mad Scientists attempting to resurrect people, keep body parts alive, create life from nothing, halt the aging process, etc. etc., usually with horrible results. The reason why things go wrong in these movies usually have more to do with man being punished for tampering in God's domain (or man being punished for using his Science for evildoing) than with any shortcomings on the part of the science itself.
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Franken Fran: No explanation needed here if you've read it, you were already nodding in agreement. If you haven't, well, These Are Things Man Was Not Meant to Know.
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Bleach: Aizen has been using shinigami science to attempt this. He's even been willing to steal the scientific achievements of others (especially Urahara's) in his pursuit of this.
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A Certain Magical Index has the Level 6 Shift project, which aims for this.
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Marquis DeSinge in Tales of Monkey Island.
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Honor Harrington: Genetic modification is somewhat frowned upon, and certain forms outright forbidden, ever since a bunch of Übermensch saw that they were "better" than humans — so they started a war that could have destroyed Earth.
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The General in Psi-Ops: The Mindgate Conspiracy used an alien psi device to gain massive psychic powers, in the process he killed dozens, lobotomized hundreds, and betrayed every one of his allies. His comeuppance was getting beat by the protagonist.
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The Terrans in the X series are extremely paranoid after their own Terraformers went crazy after a bad software upgrade, gained sentience and began "terraforming" the Earth and any Terran ships in sight. Now the Terrans have a military group — the AGI Task Force — dedicated to eradicating AI's. Considering that the terraformers became the Xenon who spent the entire series terrorizing the commonwealth, they're quite correct.
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The entire plot of the six-part G.I. Joe: A Real American Hero arc "Arise Serpentor Arise" involves Dr. Mindbender trying to emulate Frankenstein by splicing the DNA of historical figures to create a perfect leader. It doesn't turn out too well. He gets a leader, but Serpentor turns out as much a failure at leading COBRA as the Commander was.
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This is pretty much the backstory to The Matrix.
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Project F of Lyrical Nanoha, which attempts to bring back the dead by creating a clone with the memories and personality of the original. As it's a subset of Artificial Mage research mentioned under Genetic Engineering, this is also banned by The Federation. Series Dark Magical Girl and ultimately Lancer Fate Testarossa was one of the products of this project, and the development of her own personality led to her mother, Precia, being absolutely horrible to her.
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Fullmetal Alchemist: The Big Bad accomplishes just about everything this list and even some of the good guys try a few.
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In the Gentleman Bastard books, the Bondsmagi — many of whom consider themselves as far above humans as humans are above livestock, with moral compasses to match — have horror stories of a fellow mage who tried this. The magical pollution from the attempt created a plague that ravaged a city, and the mage himself was shunted into a new body without his powers or his memories, though whether the latter was a case of Gone Horribly Wrong or Gone Horribly Right is uncertain.
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Rick Sanchez of Rick and Morty has willingly committed each sin, and has even mixed & matched to create his very own affronts to the laws of God, man and nature. Highlights include creating an entire universe of tiny aliens that "worship" him by powering his spacecraft's battery, and inventing a sentient, self-aware robot for the sole purpose of passing him butter at the breakfast table. Some of this is due to power creep. In an early Season 1 episode he states matter-of-factly that he "can't cure death". In an early Season 4 episode, he discovers that, in some of infinite alternate universes, he figured it out, so the machines will resurrect him there when he dies. However, he doesn't like those universes, so he keeps comically killing himself to find different ones.
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Neon Genesis Evangelion: The creation of Evas might be this, but how they are created is never properly explained.
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Pretty much Jobe Wilkins' raison d'etre in the Whateley Universe. He has genetically engineered a synthetic Sidhe that is essentially a dark elf hottie. He has invented serums that can turn people into transhuman monsters... and he has used them on people who annoyed him. He has invented a serum that gives people strength, endurance, and healing abilities... by turning them into what amounts to feral orcs who are put to work in his father's mines.
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The resurrection gauntlets (the second, Weevil related one moreso than the original Risen Mitten) of Torchwood.
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Resident Evil: Many of the antagonists have committed a few, but Umbrella in particular seems to use this list as a checklist, with particular focus on genetic engineering, creating life, and resurrection. Wesker has also ticked off an impressive number of the items on this list for one man, with the ultimate goal of becoming a god.
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Exalted has Voidtech, which is essentially The Corruption in the form of self-replicating machines that embody the Scientific Sins, as defined by Autocthon. As with many Exalted tropes, this is played with-Autocthon embodies invention and machinery, meaning he views violation the scale as something to praise, so long as it leads to better quality of life and new discoveries in the long run. Voidtech does not care about this, only itself-in effect, what happens when actual science is warped to service greed and war.
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This trope is extensively played with in Ghost in the Shell — the impact of extensive technical progress in the area of AI and cybernetics on society forms the premise of the series.
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Marvel Universe:
Doctor Doom has done this on at least two occasions. In the first case, in Secret Wars (1984), it turns out that he isn't quite capable of handling the Beyonder's power. The second time, he gives it up because being God bores him.
Thanos loves this one. Inevitably, though, he ends up losing whatever godlike power he's gained due to his own subconscious belief that he's unworthy of it — although in one case, it's heavily implied that The One Above All was just trolling him the entire time.
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Council Wars: Creating new AIs is the only thing that is banned after a horrible war.
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Dungeons & Dragons: The Archmage Karsus from the Forgotten Realms setting created an unprecedented spell to temporarily steal a god's power. He intended to use it to defeat the Phaerimm threat, but inadvisably targeted the goddess of magic, causing a catastrophic lapse in the Background Magic Field that destroyed the Netherese Empire. History remembers him as "the child-who-would-be-a-god" or "the Ape who would fly".
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Stargate SG-1: Proclaiming themselves gods is the villainous Goa'uld's main operating procedure.
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Star Trek: Deep Space Nine: Jem'Haddar and Vorta are genetically bred (see above) to regard Founders as gods.
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Dune: The Bene Gesserit have been attempting to create the Kwisatz Haderach in secret, as he would be their puppet like prophet to control mankind with all their skills and powers. They succeed, except for the "puppet" part. Paul Atreides and his son Leto do not like being controlled.
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The beginning of Mass Effect 2 sees the trilogy's hero and main character Shepard die in an attack, only to be surgically resurrected by Cerberus on the Illusive Man's orders. The ending of Mass Effect 2 sees Shepard turn their back to the Illusive Man and Cerberus who go back to being villains in 3, while the ending of Mass Effect 3 ends badly for the Illusive Man by either being talked to death or shot by Shepard.
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Fontaine in BioShock becomes a horrendously powerful ADAM-overdosed human statue.
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Mass Effect:
The quarians built the geth as a cheap labor force. If you talk to Tali, she will eventually reveal that her people panicked when their labor automata started asking existential questions ("Does this unit have a soul?") and tried to shut them all down; the geth responded with force, driving the entire quarian race from Rannoch to wander known space in their vast Migrant Fleet for the last three hundred years. Considering that there had been billions of quarians on Rannoch before their exile, while only 17 million are alive currently, the so-called "Morning War" was a genocide of epic proportions as well (despite the geth not even wanting to annihilate their creators). This incident prompted the Citadel Council to outlaw the development and use of artificial intelligence.
According to Legion, the geth considered it self-defense; they bear the quarians no real ill-will and have preserved Rannoch for the day when the quarians will return, repopulate their world, and live peacefully together. The remaining geth have no desire to interact with biological intelligence and remain behind the Perseus Veil. A minority of geth came to believe that Sovereign was akin to a deity and followed it with their worship and actions; those "heretic" geth are the ones that Commander Shepard fights throughout the series.
It is possible to achieve peace between the two factions in the third game (provided you make the right choices), but even with the best possible outcome, sacrifices must be made. What can be surprising, however, is that if you have to choose a side because you didn't meet the requirements, the Paragon choice is to side with the geth.
Despite the Council's laws against it, you encounter two rogue AI programs in just the first game — one which evolved from a casino-cheating program, and one built by your own bosses as a tactical tool. Cerberus steals the second one and it ends up working for you under her new name, EDI, and she's alright.
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Bendy and the Ink Machine features this in its backstory. Joey Drew, who wanted people to see his cartoons in the same way he does, commissions the Ink Machine to create living versions of his characters, something that Thomas Connor thinks is "teetering on the edge of magic more than engineering". The first attempt at creating Bendy results in a soulless ink creature which Joey demands be locked up inside the studio (it escaped by the time you encounter it in-game), with no further attempts being made afterward.
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Amnesia: A Machine for Pigs: The Engineers commits #3 and #7, its plan is to slaughter everyone in London and convert them into Manpigs, and become a God by using the blood of the people killed.
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Star Trek: While future medical science is sophisticated enough that characters almost routinely come back from clinical death. However, some extreme attempts have fallen into this trope, such as Kira wanting her boyfriend, Vedek Bareil, to be rejuvenated by using artificial parts to replace decaying brain tissue in the Star Trek: Deep Space Nine episode "Life Support". This is progressive, and further replacements leave him less and less Bajoran until he asks to be allowed to die.
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I, Robot. See Asimov's entry for literature below.
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Girl Genius features resurrection as a major issue among royalty. To prevent eternal reigns death and resurrection are considered an abdication. Part of the reason for this is that Came Back Wrong is pretty common; the other part is that most heirs don't want to get back in line for the throne.
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Fullmetal Alchemist (2003) has Homunculi, who score a 4.5 being both botched resurrections and attempts at creating life.
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The N.I.C.E. in That Hideous Strength follow most of the list pretty nearly to the letter, given that they start out by tearing down a historic forest to build a factory, and wind up developing transhumanist technologies including cybernetically reanimating severed heads to give demons the ability to fight against God. Reanimation is what the rank-and-file N.I.C.E.-er (if they even know about it) thinks has happened; a few of the higher-ups seem to know (or at least suspect) that what is really going on is far worse. You know you're dealing with an evil organization when "we reanimated the head of a criminal psychopath" is your cover story.
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The Cyberpunk universe has its own problems with over using cybernetics: Cyberpsychosis. When a human adds too many augs, they eventually become more and more unhinged until they're more machine than man and become Cyber Psychos. Special police forces colloquially called "Cyber Psycho Squads", police that are almost Cyber Psychos themselves, detain these criminals to have their minds rebuilt into a more acceptable form. Some even become Cyber Psycho Cops after their prison time.
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The Genesis Planet from Star Trek II: The Wrath of Khan didn't exactly turn out well in the end.
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In the Star Trek: The Original Series episode "The Ultimate Computer", a computer, when given control, refuses to be turned off and attacks friendly ships.
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The Elder Scrolls has the Dwemer, who attempted to commit every sin on the list, with their efforts toward committing the final few leading to their disappearance. They committed Automation by blending Steampunk technologies with magical enchantments to create automated machinery and Mecha-Mooks. They committed Potential Applications by devising ways to use their technology to accomplish things well beyond their Standard Fantasy Setting contemporaries including Weather Control Machines, Humongous Mechas, and even a device capable of reading the Elder Scrolls without the nasty side-effects. They dabbled into Genetic Engineering with their treatment of the Falmer, who the Dwemer twisted so much that it changed their very souls. Upon discovering the still-beating heart of the dead god Lorkhan deep beneath Red Mountain, the Dwemer attempted to commit sins 4-7 in one fell swoop by tapping into the power of the heart. They sought to both create a new god (Anumidium) as well as allow their entire race to Ascend to a Higher Plane of Existence. However, something went wrong and caused the entire Dwemer race to blink out of existence. These behaviors obviously put them at odds with their much more religious neighbors in the Chimer, who warred with the Dwemer before their disappearance and demonized them (and their technologies) after.
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Doctor Hogback of One Piece was a famous surgeon who disappeared from the public eye to study an island full of zombies with the hope of figuring out how to achieve proper resurrection, but it turns out that he is helping to create said zombies. Chopper claims that he would have supported Hogback, no matter how many other people accused him of playing God, if he'd actually been bringing people back from the dead, but has lost all respect for Hogback upon learning that he's simply animating corpses to do his bidding.
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I Am Legend: We cured cancer and everybody died. And turned into an evil horde of zombie-vampires.
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Many of the mooks (and some of the bosses) you face in Mother 3 are either unnatural crosses of animal species (e.g., Cattlesnake, Batangutan, Kangashark) or mechanised animals (e.g., Steel Mecharilla). They only exist because Porky deemed regular animals as uncool, and so had his Pigmask army to alter them genetically.
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Herbert West–Reanimator ends with the title doctor being torn to pieces by a small army of his creations, though they take his head with them, and one of them is smart enough to reanimate the dead himself.
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Orion's Arm, despite generally displaying all of these as good things, shows disadvantages to all but immortality.
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This is the entire focus of Orphan Black, with much of the plot being driven by the inhuman manipulations of a science group (much of the rest being driven by the religious fanatics opposed to them). In some ways, though, it's quite a subversion. The Dyad Institute's villain status comes not from their science necessarily, but from their objectification of human life, disregarding the clones' well-being and their very bodily autonomy for the sake of profit. It's their intention behind the human cloning, rather than the act of cloning itself, that drives them to villain status. In fact, some of the less predatorily capitalistic members of Dyad were occasionally portrayed in a good light, such as Delphine Cormier, Aldous Leekie and Ethan Duncan.
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In Forbidden Planet the Krell's subconsciousnesses created creatures which had the power to destroy but not be destroyed.
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Deus Ex: Human Revolution focuses on this as its primary setting. Whether or not human augmentation is evil is up for the player to decide, but it does make the world worse to a degree.
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Surprise, surprise, Warhammer 40,000, albeit in an unconventional fashion: the Immortal God-Emperor of Man. The fallen Primarchs may also think of themselves this way, though they didn't elevate themselves to levels just shy of a Physical God.
Although to be fair to the old boy, he essentially made it extremely clear that he was just a (hyperpowered and nigh on invulnerable) man, not a god. You can thank the lackeys after his death who set him up as a new deity.
But those very same lackeys may have actually turned him into a deity, through the power of belief and due to how the Immaterium works.
Also, he may have known he WAS a god, but because he knew that the 40k verse runs on Clap Your Hands If You Believe he may have set out to stop any and all belief in gods in the galaxy as a way to kill off his rival gods.
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The Shadowrun universe features different examples of this trope:
Genetically engineered animals.
Cybernetically enhanced animals.
Massive-scale human cybernetics. For the sake of balance Cybernetics Eat Your Soul — any mechanical and electronic modifications chip away at magic-defining character traits and at the character's humanity score. This includes the creation of cyberzombies. Those are not undead, but literally corpses walking by their artificial parts, to the extreme of an artificially alive brain in a weapon-grade android body.
The 4th Edition introduces bioware and genetic engineering for metahumans. They cause Essence loss but not as much as cyberware.
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The El Goonish Shive universe makes some sort of LEGO Genetics easy, given some of its non-human (but not alien) residents. Still, Project Lycanthrope starts up to make weird hybrids to go on missions and assassinate. Before America Saves the Day, though, the intended target (Damien) shows up, 'liberates' (read: enslaves) the results, and kills everyone else save one. Note that in an alternate universe, one of the Project Lycanthrope products is hinted to be the reason it's now ruled by an Evil Overlord.
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Indiana Jones and the Fate of Atlantis: Mix-and-Match Critters, Eldritch Abominations, Bamboo Technology Automatons made out of stone and bronze and powered by Orichalcum, followed by The God Machine set on top of an underwater volcano, which cause the characters to either possess the wearer or mutate into A Fate Worse Than Death. Oh, and the Nazis want to restart the whole shebang.
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According to the Church of Yevon in Final Fantasy X, in the backstory Spirans relied on technology ("machina") to live proud and hedonistic lives, and Sin is their punishment, a monster attracted to technology. Later we learn that there is some political bias attached to this; Sin was a weapon created by Yevon get revenge on the technologically-advanced city of Bevelle, and later Yunalesca created the Church and its beliefs so that her people, her family and their old way of life, would be honored and preserved forever.
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Eclipse Phase has checked off each of them, although number 7 was carried out by superintelligent AI's, the TITANs, who proceeded to forcibly upload many humans, reduce Earth to a blasted hellscape, and vanish through hyper-advanced wormhole gates. Most of them are considered routine everywhere except the Jovian Junta, although attempting to create another TITAN-style "seed AI" with unlimited potential is so illegal that if you attempt it you will be killed and all your backups will be wiped, and if your habitat doesn't take you down, Firewall will.
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Doctor Who: According to "Inferno", the sin of the greedy scientists seeking to dig too deeply into the earth is so great that not only are monsters called forth and the guilty scientist punished, but the world itself is destroyed (in a parallel reality). There's no reason for this other than that scientists dared tamper with what men should not have disturbed — and this from the incarnation of the Doctor who steadfastly rejects all nonscientific explanations for observed phenomena in every other story.
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The ultimate goal of Bob Page from Deus Ex, complete with theological rhetoric and quoting Aquinas. Also J.C. Denton in the "Helios ending", closed by Voltaire's aphorism "If God did not exist, it would be necessary to invent him".
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Nearly every faction of Command & Conquer: Red Alert 3 Paradox has committed at least one of the sins. The Allies have committed sins #1 and #2, the Empire and Syndicate have committed #1, #2, and #3 (the Syndicate is worse though), the Confederates have committed #2, China has committed #2, #3, #4, #5, and the Protectorate is #1. Only the Soviets and Order of the Talon haven't committed any of the sins.
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Doctor Doom has done this on at least two occasions. In the first case, in Secret Wars (1984), it turns out that he isn't quite capable of handling the Beyonder's power. The second time, he gives it up because being God bores him.
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Wild Cards:
Demise, a projecting telepath. Projects the memory of his own death to kill. Demise had drawn the Black Queen (in the setting's Super Power Lottery, 90% of those afflicted by the Mass Empowerment Event just die horribly) and was treated with the experimental Trump cure. He Came Back Wrong.
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Battlestar Galactica (2003): "The Cylons were created by man..." To be fair, their situation is more similar to that of the geth. Plus, it was a plan of god(s) all along.
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In the backstory of the John Carter of Mars novel Synthetic Men of Mars, Ras Thavas has done this. As is par for the course, it proved to perhaps be ill-advised, which kicks off the actual story.
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The Inexplicable Adventures of Bob! has four artificial characters — Molly, Golly, Jolly, and Roofus. Of those, three were produced accidentally, with only Golly being grown deliberately. The other three are very nice people, while Golly is far and away the most emotionally screwed up and potentially dangerous of the bunch.
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Genius: The Transgression incorporates almost the entire list into the Karma Meter. In order of severity Transgressions include: automation, minor transhumanism, making zombies, dangerous experimentation on humans, creating intelligence, deadly experimentation on humans, moderate transhumanism, very deadly experimentation, major transhumanism, raising the dead, genocide.
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Averted and played straight in Buffy the Vampire Slayer. When Dawn revives their recently deceased mother while it is never seen it is implied it would have gone poorly. Buffy's resurrection on the other hand didn't have any major consequences except for the whole "opening up the opportunity that The First needed to destroy the Slayer line, and take over the world" thing.
Although being pulled out of Heaven is a bummer.
This concept was addressed in-universe when Willow tried to get Tara back after her death and was told that the reason why getting Buffy back was possible was that she died due to supernatural causes, while Tara (and Joyce) had both died normally.
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Herbert West in Re-Animator has a serum that brings the dead back to life, which he uses on anything dead he comes across. He also makes a few interesting attempts at create new life, with varied results.
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In the Eldraeverse, the advanced Transhuman polities consider this sort of thing a to-do list. Or, in many cases, a have-done list.
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Doctor Faustus set out to "gain a deity" through the study of forbidden magic and the consequently-named Faustian Pact. To say it went horribly wrong would be an understatement, but then the terms of his bargain were pretty stupid to begin with.
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In Cyberpunk 2077, Evil, Inc. Mega-Corp Arasaka devises a Brain Uploading program that they advertised as immortality for the uber-wealthy (and anyone unfortunate enough to wind up as one of their test subjects). Johnny Silverhand sees this as a cardinal sin, stating that they've found a way to deny people the right to die.
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Crimson Dark shows humanity's way from prosthetics to augmentation. While there are laws to prevent Ghost in the Shell scenarios, at least one side of the in-universe conflict employs literal cases of Cybernetics Eat Your Soul — technically dead human bodies, augmented and modified beyond recognition, held alive by said augmentations with conscience replaced by AI, referred in-universe as JAKs.
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Tales of the Abyss again, under the same concept. Fomicry as used to create human clones was originally an attempt to bring back the dead. It never worked right, though — not only were many replicas physically imperfect, often in horrifying ways, but not a single one of them ever had the original's memories.
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Raistlin Majere in War of the Twins sets out to overthrow Takhisis and take her place. Bad Future seen by his brother in the final book of the trilogy reveals were he to succeed he would then kill all other gods in the world.
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Babylon 5: The Vorlons genetically engineered the Younger Races to perceive them as angels.
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Hellsing makes a good college go at it — Millennium only missed one point. If Doktor had thought to make some robots they'd have checked off everything.
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Messiah is a literal case; Earth has turned into a technological dystopia, and humanity not only has rejected God, it's planning to convert His power for selfish reasons, and has actually achieved limited success already, so much that He can no longer influence or even view it. Bob — the player's character — is sent on a mission to investigate.
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Kirby: Planet Robobot: The employees of Haltmann Works Company run afoul of this. Finishing the entire game and discovering the complete lore reveals that there's more to it than simple ambition.
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The following is a list of statements referring to the current page from other pages.

 Scale of Scientific Sins
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Speculative Fiction Tropes
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