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Synthetic Plague

 Synthetic Plague
type
FeatureClass
 Synthetic Plague
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Synthetic Plague
 Synthetic Plague
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SyntheticPlague
 Synthetic Plague
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So The Plague is wreaking havoc on the world's population. Maybe Super Flu has killed millions, or some unknown biological agent is causing people to snap and kill each other. Heck, maybe we even have a good old fashioned Zombie Apocalypse on our hands. Either way, it's safe to say that for most of humanity, these are not fun times. How could things get much worse, you ask?
By the revelation that the disease in question has been manufactured by genetic engineering, and possibly is distributed by humans. The untold amount of death and destruction has been directly caused by the foolish or malicious action of Man himself.
It may have been designed for use as a biological weapon, or an unexpected result of an experiment gone wrong. Perhaps we just shouldn't have let monkeys watch TV for too long. However it came to be, it has now been unleashed on humanity at large, and has almost certainly gone far beyond what its designers had originally intended.
In works that involve these types of diseases, expect an Aesop about the hubris of man, and the evils of unchecked science. In most cases, those behind the creation of the disease will often fall victim to it as well, either directly or indirectly. Scientists who worked on the original project may cry out "My God, What Have I Done?"
Synthetic Plagues are favorite weapons of Mad Scientists and Plaguemasters alike. Note that in works where multiple sentient, technologically advanced species exist, any disease created by one of those species would qualify. The key defining point in this case is that the disease in question does not occur naturally, but is instead created or nudged along by intelligent creatures.
A Sub-Trope of The Plague, and one that can often serve as a form of Depopulation Bomb and/or Superweapon. Compare Mystical Plague, The Virus, Apocalypse How, Biological Weapons Solve Everything, and Genetic Engineering Is the New Nuke.
 Synthetic Plague
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2024-02-29T07:45:29Z
 Synthetic Plague
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2024-02-29T07:45:30Z
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DBTropes
 Synthetic Plague / int_11b7db91
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Synthetic Plague
 Synthetic Plague / int_11b7db91
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Adventure Time: Several years before the present day, the Mad Scientist Dr. Gross created an infectious virus which was accidentally released, resulting in the greatest cataclysm to the human species in centuries, killing off two-thirds of the last functioning human colony on Earth. Finn's mother was one victim of the illness; she only survived because of Brain Uploading before the disease killed her.
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Synthetic Plague
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Jane, Unlimited: The development of a man-made plague plays into the espionage story. As it turns out, it's not quite as synthetic as most examples, as it's a strain of smallpox. They have to hurry to get it contained before it's released back into the world.
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Twig: These are a standard part of the Crown's repertoire. But the biggest example is the "Red Ravage" plague that appears partway through the story. It's insanely infectious, causes as much pain as is possible in its host, and can survive as ivy-like growths outside a human body and propagate itself that way too. Also, it's incubation time appears to be random. Various characters immediately pick up that it's clearly an artificial plague, but nobody can figure out who made it, as it doesn't seem to fit either the Revolution's or the Crown's goals. It's actually a creation of the final Primordial that was killed in the Battle of Lugh, which engineered the plague during its last moments as a final act of spite against humanity for killing it.
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Synthetic Plague
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Bonesaw of Worm creates a prion-based amnesia plague.
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 Worm
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 Synthetic Plague / int_162b751d
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Synthetic Plague
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In the Jacob's Ladder Trilogy, an engineered strain of influenza is used as a biological weapon. It is designed to be potent enough to afflict even Exalts, who have nanomachine-enhanced immune systems.
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Synthetic Plague
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In Blood Music, artificial lymphocytes convert the entire biomass of North America into versions of themselves.
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1.0
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Synthetic Plague / int_18284e18
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Synthetic Plague
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Master of Orion allows the player to research biological weapons to wipe out planetary populations without damaging colony improvements. However, this causes every other faction to despise the user.
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Synthetic Plague
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Escape from the Moon: As Spliced Genome, Doa created a number of these that killed millions and infected billions more.
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 Escape From the Moon / Fan Fic
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 Synthetic Plague / int_1a5d84af
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Synthetic Plague
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The blood plague from 20th Century Boys is one of these, as it is continuously strengthened throughout the series to cause ever greater devastation.
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 Synthetic Plague / int_1c296808
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Synthetic Plague
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The scientists in Rise of the Planet of the Apes aren't trying to create a synthetic plague, they're trying to create a cure for Alzheimer's. Unfortunately for them, not only does the ALZ-113 give sentience and super-intelligence to apes, it's also fatal to humans... and it's an airborne virus. Nice Job Breaking It, Hero. The Viral Marketing website Simian Flu implies that only one-tenth of the population survived. Dawn of the Planet of the Apes reveals that only small pockets of humans survived — those with a natural immunity to the plague. War for the Planet of the Apes reveals that it's mutating to affect the remaining population: it robs them of the ability to speak. The Colonel claims that it also robs humans of their intelligence, but as seen on the film's YMMV page, there's room for debate on that.
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A Certain Magical Index: The Kremlin Report is a form of defense made by the Russian military, used in the event when nuclear facilities are likely to be taken over by an enemy, as seen during World War III against the Academy City forces. It is basically a wall which emits a bacteria which is both resilient and highly destructive. The Academy City forces settled this by bombing the power generator feeding the Kremlin Report.
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Synthetic Plague
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In Helix, its clear that the outbreak of The Virus at an isolated research facility originates from mysterious, ethically-dubious research into biological superweapons, but Arctic Biosystems' staff is willfully opaque as to the details, hamstringing the efforts of the CDC rapid response team to contain its spread. It eventually turns out that Arctic Biosystems' parent company, Illaria Corporation, is run by a cabal of immortals who were using Arctic Biosystems' research to develop both a plague to "thin the herd" of global population, and a cure to bully the survivors into servitude with.
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Synthetic Plague
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In the Heroes/Twilight crossover "Dark Days", the primary threat is an artificially engineered variation of the Shanti virus that can even infect vampires, reducing them to feral monsters for a few days before it finally kills them by destroying their brains. Even worse, those vampires infected with this disease will turn anyone they bite, whether humans or other vampires, into other infected vampires, forcing the Cullens and their allies to devise a cure before the disease reaches critical levels.
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Synthetic Plague
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In the Hc Svnt Dracones novel Fate's Fangs, Nadia has a side job getting inoculated with supposedly benign viruses that carry isotope tags so that the medical corporation that owns her home city can study the spread of disease. After one of her clients in her primary job drops dead mid-session, suspicions are raised.
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Synthetic Plague
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Several episodes of The Outer Limits (1995) feature wholly artificial or genetically altered diseases.
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 The Outer Limits (1995)
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 Synthetic Plague / int_32066b8e
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Synthetic Plague
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In V for Vendetta, the St. Mary's Virus was a major factor in Norsefire's rise to power. Blamed on religious extremists, it's later revealed that the government developed it through experiments conducted on prisoners at the Lark Hill detention facility, and chose to attack their own people to create an environment of fear that would cause the people to give the government more power.
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Synthetic Plague
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This trope is a big part of Genocide Man. Most of the world's population was killed off by a series of designer plagues before the comic, and the titular Super Soldiers carry briefcase-sized biology labs so that they can use tailored plagues to wipe out the genetic deviants they are sent to exterminate.
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 Genocide Man (Webcomic)
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Isle of Dogs: Dog flu was invented by Kobayashi Pharmaceuticals to give the dynasty a pretext for removing all the dogs.
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During the Assassination Island arc of Assassination Classroom, eleven of the students are infected by a potentially fatal virus with varying symptoms — some are still on their feet, while others are vomiting blood, and Terasaka was able to hide his symptoms for hours. This was subverted when it was revealed that Gastro, Grip and Smog withheld using the plague in favor of a relatively harmless stomach flu that will eventually wear off because they only had to make the students think that they would die, and they didn't want the stigma of killing middle-school kids on their reputation, even if it meant defying Takaoka, their psychopathic employer.
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 Assassination Classroom (Manga)
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During the New Jedi Order series, the war against the Yuuzhan Vong goes badly enough that a synthetic plague called "Alpha Red" is created, which specifically targets the Vong and their Organic Technology, killing them within days. It is deemed unethical and condemned by the heroes, but still gets released here and there by certain elements in the Alliance. The Vong weren't above using their own synthetic plagues, including one nasty variant released on Ithor that also had the side effect of over-oxygenating the atmosphere, so anything surviving the plague had global firestorms to look forward too. One of the many arguments against Alpha Red was that it might spur the Vong to retaliate in kind, potentially sterilizing the entire galaxy.
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Synthetic Plague
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Humanity's downfall in the backstory of Janitors of the Post-Apocalypse came through one of these, killing half of the population and rendering the other half into Technically Living Zombies known as 'feral humans'. The reason why someone made something like that is unstated, but their uplifted descendants tend to think pre-plague humans were just that combative and ready to kill each other. Late in the first book, we learn that there had been a First Contact Faux Pas that resulted in a human representative being in a coma, and humans engineered a virus to get her functioning again which only half worked and then escaped. The next book treats the feral plague as just a disease the Krakau accidentally brought to Earth instead.
 Synthetic Plague / int_4119a976
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 Synthetic Plague / int_459fcf85
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Synthetic Plague
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The Star Trek Shatnerverse novel Avenger involves a plague spreading through the galaxy. It turns out that not only was it engineered by a group of Well Intentioned Extremists, one of the key members was Sarek, Spock's father. When he later tried to reveal the truth, he was poisoned in such a way as to mimic Bendii Syndrome. In fact, one of the original test worlds was Tarsus IV, and Sarek mind-melded with young Kirk to erase his memories.
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Synthetic Plague
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The Shadow: In "Murder on Approval", a dastardly doctor invents a highly deadly plague, and tests it out by releasing it in a U.S. Army barracks.
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 The Shadow (Radio)
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Synthetic Plague
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Ebin and May has a case of biological warfare, but due to Fantastic Racism, it only affects the lapines, as seen in this strip.
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1.0
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Synthetic Plague
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Final Fantasy XIV has a very interesting take on this. At the end of Stormblood, we're introduced to Black Rose, a chemical weapon created by the Garleans intending on wiping out the Eorzeans. However, in a Bad Future, it turns out the Flood of Light from The First would transform Black Rose into a synthetic virus that would bring about the Eighth Calamity, killing the Warrior of Light, the Scions and many, many others. The events of Shadowbringers are a Set Right What Once Went Wrong plan, intending on saving The First so that the weapon isn't used that way. Thankfully, the weapon is also destroyed by a Came Back Strong Zenos, who refuses to let such a cowardly weapon take his chance to destroy the Warrior of Light.
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Spawn (1997): According to Wynn, Heat-16 "makes the Ebola virus look like a skin-rash!". He intends to conquer Earth with it, while Hell means to use it to wipe out the Earth.
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Ever17: The accident in the underwater amusement park is caused by Leiblich Pharmeceuticals attempting to cover up the fact that a very deadly virus they manufactured, Tief Blau, had been released within the park.
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ANNIE: Last Hope has a mysterious outbreak of a zombie virus from a new, genetic viral strain caused by some insects called "crabs". The virus turns out to be artificially created by an Evilutionary Biologist who starts the plague deliberately in order to rule over the zombies.
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Synthetic Plague
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In Crimestrikers, the titular menace in "The Hydreran Plague" is bioengineered by PARCH, a racist terrorist group, to affect only Hydrerans (a race of Fish People).
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Mass Effect: Annihilation: The Forntibras Plague which spreads through the Keelah Si'yah. As the doctor who's first revived to study it notes, many of the symptoms come from varied species, and their radically different biochemistry should make this either difficult or flat-out impossible. It turns out the ship's captain deliberately cooked it up to wipe out the humans, turians, salarian and asari in the Andromeda Initiative. She failed to consider the virus might spread out of control and move on to other species in the meantime.
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In The Stars Are Cold Toys, the Geometers are masters of genetic engineering. Their current social structure is a direct result of them employing a Synthetic Plague to wipe out another sentient race on their homeworld that was attacking them. It is also discovered that the plague that devastated the Geometer population at some point in the past was designed by the same scientist who later developed their version of penicillin to fight it, at the request of the Mentors who wanted to restructure the society. Pyotr realizes that, if the Conclave goes to war with the Geometers, they will probably end up destroying their homeworld, but the surviving Geometers will continue to conduct hit-and-run attacks against Conclave worlds, releasing deadly plagues where they can.
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In The Empress Game, the Sakien Empire created a nanotech virus as a bioweapon, but it got loose and is doing a lot of damage. This caused the Empire to invade the planet of Ordoch, which had refused to provide a cure on the grounds that the technology involved could have created an even worse weapon, and the Empire had already demonstrated itself unfit to be trusted with that kind of thing. However, the Empire still hasn't managed to compel Ordoch to produce a cure and can't hold the planet in the long run.
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In At the Edge of Lasg'len, a fallen Maia-turned-scientist engineers a virus that wipes out ninety percent of humanity in 2037.
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In Death Masks, creating a magical plague like this is the objective of Nicodemus, using the magical power of the Shroud of Turin. Nicodemus isn't doing it for any reason beyond to cause chaos and death, which he views as its own end.
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The second arc of Young Jedi Knights features a similar plague... aimed at humans and humans only. The Diversity Alliance's insane leader seeks to find and unleash it. Later, the characters discover that the Empire had created plagues specifically targeting each individual species. The asteroid containing the viruses is destroyed, though the fight that ensues does end up releasing some viruses, which infect both the father of one of the knights and the leader of the Diversity Alliance. The father sacrifices himself to ensure that the asteroid blows up. The leader tries to fly to Coruscant to spread the disease, but her disillusioned number two subdues her and flies her to parts unknown to die.
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 Young Jedi Knights
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Synthetic Plague / int_540d133b
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Synthetic Plague
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In Rainbow Six, as part of a two-part plan, an Eco-Terrorist group intends to release a modified version of the Ebola virus, code-named "Shiva". The second half of their plan is to distribute a fake vaccine (that's actually still the virus) in order to make sure it gets distributed as fully as possible. They're pretty devious, in that they'll distribute two versions of the vaccine: one that works and one that really, really doesn't; the purpose of the first is both to fool the general populace into thinking that they're getting the cure, and to save themselves and the few people they deem necessary for building an environmentally friendly future. They come very close to succeeding, too.
 Synthetic Plague / int_58173119
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1.0
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1.0
 Rainbow Six
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Synthetic Plague / int_58173119
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Synthetic Plague
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The plot of Crusade is that a race known as the Drakh decide to attack Earth. While they fail to destroy Earth when their Planetkiller is destroyed, their Plan B is to release a deadly and highly virulent plague on Earth to wipe out the majority of humanity. Later on, it's discovered that the virus is, in fact, not only artificial but also non-biological in nature. It's actually nanites actively seeking to adapt themselves to human physiology, a process estimated to take about 5 years, during which many humans keep dying from various "mutations" of the plague. The mission of the crew of the Excalibur is to find the cure before time runs out. One episode involves a formerly inhabited world whose denizens have mysteriously disappeared. It turns out that this was also caused by a nanite-based virus, this one being of the Hate Plague variety. It causes the infected to go berserk on anyone nearby and then snap back into normal without any memory of what happened (possibly, adding halucinations of a shadowy figure doing the dirty deed).
 Synthetic Plague / int_58bcf32e
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1.0
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1.0
 Crusade
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Synthetic Plague / int_58bcf32e
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Synthetic Plague
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Iron Helix: The "Iron Helix" is a biological weapon that attacks the infected's cells, mutating their DNA and rendering their bodies unable to carry out vital metabolic functions, which kills them within only a few hours.
 Synthetic Plague / int_5a34e5e3
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1.0
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1.0
 Iron Helix (Video Game)
hasFeature
Synthetic Plague / int_5a34e5e3
 Synthetic Plague / int_5b28dc78
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Synthetic Plague
 Synthetic Plague / int_5b28dc78
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In Hoshin Engi, Ryou Gaku is a Mad Scientist Sennin whose disciples wear special paope suits which allow them to spread clouds of a deadly plague he made himself. He uses it to debilitate the entire Zhou army and the heroes. A vaccine can be produced from a sample of his blood. Much later, he mentions that his personal paope Onkosan allows him to generate these, but he's killed before he can show any ability.
 Synthetic Plague / int_5b28dc78
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1.0
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1.0
 Hoshin Engi (Manga)
hasFeature
Synthetic Plague / int_5b28dc78
 Synthetic Plague / int_5bd0554b
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Synthetic Plague
 Synthetic Plague / int_5bd0554b
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Warcraft III's undead plague. Deliberately made by the scourge to create more minions, it took some time for the targeted humans to figure out what it was for and where it came from.
 Synthetic Plague / int_5bd0554b
featureApplicability
1.0
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1.0
 Warcraft (Video Game)
hasFeature
Synthetic Plague / int_5bd0554b
 Synthetic Plague / int_5e150650
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Synthetic Plague
 Synthetic Plague / int_5e150650
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Exalted: Downplayed with Great Contagion. Not because it has minimum effect, but because its primary beneficiary, the Deathlord known as the Dowager, did very little to shape it into the all-consuming death that killed just about everyone. Its original strain came from another dimension.
 Synthetic Plague / int_5e150650
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1.0
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1.0
 Exalted (Tabletop Game)
hasFeature
Synthetic Plague / int_5e150650
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Synthetic Plague
 Synthetic Plague / int_5fa8e894
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In Newsflesh, the Zombie Apocalypse was triggered by the interaction of two synthetic viruses designed to cure cancer and the common cold. Scientists wanted to extensively test both before dubbing them fit to release to the public, but a Well-Intentioned Extremist felt that the wait was too long and basically dropped the virus on major population centers.
 Synthetic Plague / int_5fa8e894
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1.0
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1.0
 Newsflesh
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Synthetic Plague / int_5fa8e894
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Synthetic Plague
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Stargate-verse:
The Hoffan Plague spread by Micheal in Stargate Atlantis in an effort to cripple the Wraith. For reference, a group called the Hoffans created a drug that, if taken, would render one immune to Wraith feeding, and indeed poisonous to the Wraith. It also had a 50% mortality rate among those who took it; they were aware of this, and took it anyway. The Wraith slaughtered the survivors. Micheal got a hold of it, turned it into a disease (albeit with "only" a 33% mortality rate), and spread it to as many human populations as he could in order to poison the Wraith's food supply.
In backstory to the Stargate SG-1 episode "Prisoners", Linea was imprisoned as "the Destroyer of Worlds" for creating a plague that wiped out over half the population of the planet Rillaan.
In the later seasons of SG-1, one of the Ori's favorite tricks for gaining new followers was have their Priors (priests) secretly unleash a deadly plague upon a population, then have the Priors publicly show up and miraculously cure that plague. They also try to use it as a bio-weapon against Earth, but a Heel–Face Turn-ed Prior uses his power to cure it (and is immediately killed by the Ori for his treachery).
 Synthetic Plague / int_605dd875
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1.0
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1.0
 Stargate-verse (Franchise)
hasFeature
Synthetic Plague / int_605dd875
 Synthetic Plague / int_63e72a51
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Synthetic Plague
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2000 AD:
Judge Dredd: There have been many instances in the comic where hostile factions resorted to biological warfare by spreading lab-manufactured diseases among enemy populations. The worst one was probably the Chaos Bug, a Hate Plague designed by leftover factions of East Meg One that started an epidemic in Mega City One resulting in the death of about 85% of the population.
Shakara: The Shakara Federation was wiped out by an engineered disease known as the Red Death. Its creator had noble intentions in doing so because of the ruthless order that the Shakara imposed on the rest of the universe, but became The Atoner when the alliance that funded her plunged it back into an age of chaos and tyranny.
 Synthetic Plague / int_63e72a51
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1.0
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1.0
 2000 AD (Comic Book)
hasFeature
Synthetic Plague / int_63e72a51
 Synthetic Plague / int_6819fb9f
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Synthetic Plague
 Synthetic Plague / int_6819fb9f
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The Ebola Brahma virus in Rainbow Six, which the Phoenix group plans to use as a Depopulation Bomb by setting it off at the closing ceremonies of the Olympics.
 Synthetic Plague / int_6819fb9f
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1.0
 Synthetic Plague / int_6819fb9f
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1.0
 Rainbow Six (Video Game)
hasFeature
Synthetic Plague / int_6819fb9f
 Synthetic Plague / int_688cfe4e
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Synthetic Plague
 Synthetic Plague / int_688cfe4e
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In Black Tide Rising, H7D3 is a purposefully designed, multi-stage agent that ultimately turns its victims into very aggressive humans with no real sapience, basically being little more than two-legged, vicious feral animals.
 Synthetic Plague / int_688cfe4e
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1.0
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1.0
 Black Tide Rising
hasFeature
Synthetic Plague / int_688cfe4e
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Synthetic Plague
 Synthetic Plague / int_69230caf
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Intergalactic: Commonworld created a virus which turns people temporarily into monsters and spread it among outworld settlers, demonizing them so that they could justify "intervention".
 Synthetic Plague / int_69230caf
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1.0
 Synthetic Plague / int_69230caf
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1.0
 Intergalactic
hasFeature
Synthetic Plague / int_69230caf
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Synthetic Plague
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Shakara: The Shakara Federation was wiped out by an engineered disease known as the Red Death. Its creator had noble intentions in doing so because of the ruthless order that the Shakara imposed on the rest of the universe, but became The Atoner when the alliance that funded her plunged it back into an age of chaos and tyranny.
 Synthetic Plague / int_69735f15
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1.0
 Synthetic Plague / int_69735f15
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1.0
 Shakara (Comic Book)
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Synthetic Plague / int_69735f15
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Synthetic Plague
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Utopia (US): Christie Corp, a pharmaceutical company, has created viruses numerous times which caused several outbreaks, with the plot centering on preventing their latest and worst.
 Synthetic Plague / int_6c1f4c9d
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1.0
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1.0
 Utopia (US)
hasFeature
Synthetic Plague / int_6c1f4c9d
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Synthetic Plague
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In backstory to the Stargate SG-1 episode "Prisoners", Linea was imprisoned as "the Destroyer of Worlds" for creating a plague that wiped out over half the population of the planet Rillaan.
 Synthetic Plague / int_70814599
featureApplicability
1.0
 Synthetic Plague / int_70814599
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1.0
 Stargate SG-1
hasFeature
Synthetic Plague / int_70814599
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Synthetic Plague
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One of the key elements of The Cassandra Crossing is a plague virus which the US military has engineered to be a biological weapon and then secretly and illegally parked in neutral Switzerland. It can't be that good, though, if it can easily be healed with oxygen within an hour or two.
 Synthetic Plague / int_72b62793
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1.0
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1.0
 The Cassandra Crossing
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Synthetic Plague / int_72b62793
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Synthetic Plague
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Pebble in the Sky: In chapter 15, "The Odds That Vanished", Dr. Shekt explains how the Society of Ancients has developed a variation of the common fever which will be incredibly virulent and, as far as Outsiders are concerned, incredibly deadly.
 Synthetic Plague / int_73afd310
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1.0
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1.0
 Pebble in the Sky
hasFeature
Synthetic Plague / int_73afd310
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Synthetic Plague
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Star Trek: Deep Space Nine:
In "Armageddon Game", O'Brien and Bashir are helping a planet destroy their stocks of a biomechanical virus called Harvesters. Unfortunately, the weapons are so terrible the inhabitants are determined that no knowledge of how to make them should survive, even in the hands of Starfleet personnel.
In an attempt to end the Dominion War, Section 31 creates a disease and uses Odo as a carrier to spread it to the Founders.
"The Quickening" shows that the Dominion themselves used one on an alien planet for resisting their control. The entire surviving population is infected, and has been for generations. The disease remains dormant for a seemingly random amount of time before suddenly activating, followed by an excruciating death. Worse, it's exacerbated and mutated by electromagnetic radiation, meaning anyone attempting to cure it will be extremely limited in technology, and the entire civilization was forced into Medieval Stasis.
 Synthetic Plague / int_73d7930f
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1.0
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1.0
 Star Trek: Deep Space Nine
hasFeature
Synthetic Plague / int_73d7930f
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Synthetic Plague
 Synthetic Plague / int_75149ccd
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The overarching plot of the first four novels of the X-Wing Series concerns the Krytos virus. Ysanne Isard, the Director of Imperial Intelligence and de facto ruler of the Galactic Empire, concludes that the diminished Empire is in no state to defend the capital world of Coruscant, and so decides to use the entire planet as a trap for the New Republic by seeding it with a plague synthesized from several of the galaxy's most lethal and infectious diseases. As per her specifications, the results are 100% lethal (Gamorreans get to the point where moving their bodies ruptures their skin, while Quarrens liquify) and highly contagious... except humans and Bothans are wholly immune, and the disease is easily treatable with bacta, an expensive medicine that is commonly used to treat battlefield injuries. This ensures that by taking the planet meant to firmly establish their legitimacy, the Rebels will inherit a humanitarian disaster that will bankrupt them to combat (a situation made worse when Isard seizes the only planet in the galaxy that produces bacta), while also stirring up anti-human resentment among the other races of the Alliance (which is exacerbated by the Bothans, being a species of politicking opportunists). Fortunately for the New Republic, Rogue Squadron is able to capture Coruscant two weeks ahead of Isard's timetable and in a way that destroys some of the virus reserves, while technicians also come up with alternative treatments that are cheaper and require less bacta. Meanwhile, the fact that Krytos was so lethal meant that infectees often died before spreading it to its fullest extent.
 Synthetic Plague / int_75149ccd
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1.0
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1.0
 X-Wing Series
hasFeature
Synthetic Plague / int_75149ccd
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Synthetic Plague
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Everland has the Horologia virus, created from a poisonous apple by Queen Katherina and unleashed onto England. The virus quickly wipes out its adult population while slower to take affect on those eighteen and under. Females are particularly vulnerable to it.
 Synthetic Plague / int_765ffd16
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1.0
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1.0
 Everland
hasFeature
Synthetic Plague / int_765ffd16
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Synthetic Plague
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Everyone suspects that the plague on Omega in Mass Effect 2 is human-made because it kills all species except humans (and Vorcha, who are immune to all disease and help spread it). However, it turns out that while it is, indeed, artificial and intended to wipe out non-humans, it was created by the Collectors for the purpose of isolating the humans they want to harvest by killing everyone else.
 Synthetic Plague / int_7668653a
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1.0
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1.0
 Mass Effect 2 (Video Game)
hasFeature
Synthetic Plague / int_7668653a
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Synthetic Plague
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In the Fallout series, there were some accusations that the US government created and spread the New Plague, not Chinese agents as was officially claimed. Whilst that is an unproven theory, a canonical example of a Synthetic Plague in the series is the Forced Evolutionary Virus, or FEV. Originally, this was intended to be a Beneficial Disease; created under the title "Pan-Immunity Virion Project (PIVP)", it was intended to be an inoculation against the New Plague and against bio-warfare attacks. However, when the government discovered the virus' Mutagenic Goo properties, they scrapped that project, redubbed it FEV, and tried to militarize it in the form of a Super Serum. All they achieved was creating the savage, dangerously uncontrollable Super Mutants, and a myriad of other horrors. Samples of the virus were later recovered by the Enclave from the ruins of the Mariposa Military Base in California. These samples were used to create weaponized variants of the FEV that could be spread into the jet stream (in Fallout 2) or in the water (in Fallout 3) to kill off all lifeforms with genetic damage accumulated from exposure to radiation and other toxins as a result of the Great War, with the only survivors being "pure" humans such as Enclave citizens or the few Vault Dwellers still in functional Vaults.
 Synthetic Plague / int_76b8cb10
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1.0
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1.0
 Fallout (Franchise)
hasFeature
Synthetic Plague / int_76b8cb10
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Synthetic Plague
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Sword of the Stars:
Several can be deployed by ships with "biowar" modules. Most do damage to planetary populations without destroying infrastructure or terraforming (unlike the other options), but vaccines against them are easily researched.
Plague and Retro Plague are standard lethal diseases, Beast Bomb reduces populations to animalistic intelligence so no production is possible, and Assimilation Plague converts victims to the attacker's empire.
The Zuul are immune to all bioweapons though, being genetically engineered soldiers after all. With the exception of the Xombie plague in the second game.
 Synthetic Plague / int_77677ed1
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1.0
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1.0
 Sword of the Stars (Video Game)
hasFeature
Synthetic Plague / int_77677ed1
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Synthetic Plague
 Synthetic Plague / int_78640f76
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This is the sub-plot in Highlander: The Search for Vengeance, as Marcus has released a virus over New York to wipe out all of people who haven't conformed to his ancient Roman ideals. The virus only has an 80% kill rate, but by the end of the movie, he's managed to make a 100% lethal version.
 Synthetic Plague / int_78640f76
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1.0
 Synthetic Plague / int_78640f76
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1.0
 Highlander: The Search for Vengeance
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Synthetic Plague / int_78640f76
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Synthetic Plague
 Synthetic Plague / int_78d38339
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As in the film series it spawned, Resident Evil involves fighting the horrors spawned by the Umbrella Corporation created T-Virus.
 Synthetic Plague / int_78d38339
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1.0
 Synthetic Plague / int_78d38339
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1.0
 Resident Evil Film Series
hasFeature
Synthetic Plague / int_78d38339
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Synthetic Plague
 Synthetic Plague / int_79a1465e
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The descolada in Speaker for the Dead and Xenocide is an artificially created super-virus that systematically dismantles and reassembles the DNA of its host. It's an unusual example in that while it's fatal — and nastily so — to Earth life, it is absolutely vital to the ecosystem of Lusitania, necessitating an approach to the disease that doesn't eradicate the pathogen entirely. In Children of the Mind, it's discovered that its deadliness is only a side effect; its true purpose is to terraform alien worlds to be more hospitable to its creators.
 Synthetic Plague / int_79a1465e
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1.0
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1.0
 Speaker for the Dead
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Synthetic Plague / int_79a1465e
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Synthetic Plague
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Counterpart (2018): Many people on Earth Prime believe the Munchen virus that devastated them back in the 90s was artifically created on Earth Alpha before being released into their side. Because of this, a faction plotted vengeance by sending infiltrators over to murder their counterparts, take their places and then subvert Alpha's society from the inside. It's eventually revealed they're right, it was artificially created on Alpha, but left unclear if this had been deliberately or accidentally released to their side. In the series finale it's indicated they released a virus of their own on Earth Alpha in revenge.
 Synthetic Plague / int_79d34d4d
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1.0
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1.0
 Counterpart (2018)
hasFeature
Synthetic Plague / int_79d34d4d
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Synthetic Plague
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Pandemic and its various versions and clones all involve an engineered plague whose goal is to infect and kill every human in the world before the world governments can research a cure/vaccine and stop it.
 Synthetic Plague / int_7ddd14bc
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1.0
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1.0
 Pandemic (Video Game)
hasFeature
Synthetic Plague / int_7ddd14bc
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Synthetic Plague
 Synthetic Plague / int_7fc78282
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In The Lord of the Rings, of all places, Sauron employed synthetic plagues at various points in the Backstory to weaken his enemies before more traditional conquest.
 Synthetic Plague / int_7fc78282
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1.0
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1.0
 The Lord of the Rings
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Synthetic Plague / int_7fc78282
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Synthetic Plague
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Star Trek:
Star Trek: New Frontier has the Redeemer virus, a plague engineered by the Redeemers and carried in their High Priests' blood, so that any non-natural death wipes out everything on the planet he died on within a few days. Naturally, said High Priests are stationed on newly "redeemed" planets, and occasionally (as in Dark Allies) used as a weapon of influence.
In the Double Helix series (set primarily during the Star Trek: The Next Generation era), a shadowy malefactor sponsoring medical research appears to be purposely infecting different planets in order to test out the most efficient way to send out viruses to kill off as many Federation citizens as possible.
The Star Trek Shatnerverse novel Avenger involves a plague spreading through the galaxy. It turns out that not only was it engineered by a group of Well Intentioned Extremists, one of the key members was Sarek, Spock's father. When he later tried to reveal the truth, he was poisoned in such a way as to mimic Bendii Syndrome. In fact, one of the original test worlds was Tarsus IV, and Sarek mind-melded with young Kirk to erase his memories.
 Synthetic Plague / int_81692f99
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1.0
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1.0
 Star Trek (Franchise)
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Synthetic Plague / int_81692f99
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Synthetic Plague
 Synthetic Plague / int_84986bf9
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RuneScape has an interesting example in the Elf Quest series. In a quest, you learn that the plague in West Ardougne is faked by King Lathas of East Ardougne after his brother, King Tyras, turned evil.
 Synthetic Plague / int_84986bf9
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1.0
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1.0
 RuneScape (Video Game)
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Synthetic Plague / int_84986bf9
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Synthetic Plague
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Cybonic plague from Transformers: Prime. When Optimus becomes infected, the Autobots must enter the mind of the virus's creator, a comatose Megatron, to seek a cure.
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1.0
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1.0
 Transformers: Prime
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Synthetic Plague / int_85a5a3b9
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Synthetic Plague
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In Gift From the Princess Who Brought Sleep, the main villain Margarita Blankenheim creates an airborne toxin out of the titular poison, Gift, which works exactly like a plague.
 Synthetic Plague / int_8905d105
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1.0
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1.0
 Gift From The Princess Who Brought Sleep
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Synthetic Plague / int_8905d105
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Synthetic Plague
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Courtship Rite has a synthetic plague of locusts. Oelita discovers a native species of insect which is eating wheat and not dying. Normally, native life finds Terran life as poisonous as Terran life finds native life. When the Kaiel get a sample of the insect, they discover it has been deliberately genetically modified, and furthermore, the Mnankrei are standing by with ships of grain waiting for the famine these bugs will cause, so they can trade food for fealty.
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1.0
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1.0
 Courtship Rite
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Synthetic Plague / int_8976f8e2
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Synthetic Plague
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TimeRiders: The Konsong-ni Virus was designed as a bioweapon by Japan.
 Synthetic Plague / int_8a8fb433
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1.0
 Synthetic Plague / int_8a8fb433
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1.0
 TimeRiders
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Synthetic Plague / int_8a8fb433
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Synthetic Plague
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Next (2020): Next develops one using the technology at Biomotion Dynamics, with Somalian terrorists supplying test subjects by kidnapping villagers.
 Synthetic Plague / int_8af3d896
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1.0
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1.0
 Next (2020)
hasFeature
Synthetic Plague / int_8af3d896
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Synthetic Plague
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NCIS: In "SWAK", the office experiences a biological attack in the form of genetically-altered Yersinia pestis which is resistant to antibiotics, stolen from a pharmaceutical lab. Tony is revealed to have been infected.
 Synthetic Plague / int_8d81bb26
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1.0
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1.0
 NCIS
hasFeature
Synthetic Plague / int_8d81bb26
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Synthetic Plague
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The Centurions episode "Sungrazer" begins with Big Bad Doc Terror unleashing the Z-80 virus, which causes humans to lapse into a catatonic state.
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The Quantum virus from Animorphs, first referenced in The Andalite Chronicles and finally seen firsthand in The Hork-Bajir Chronicles. An even deadlier virus is featured in The Arrival.
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The Underland Chronicles: The Reveal at the end of Gregor and the Curse of the Warmbloods is that the disease called "the Curse of the Warmbloods" was a biological weapon that escaped from a Regalian lab. Its creator didn't tell anyone she had the cure because she didn't want to admit she'd created the plague.
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In BattleTech, bio-engineered plagues have resulted in the destruction of multiple planets.
Most infamously, the Draconis Combine planet of Galedon V had a bioweapon get released during the Word of Blake Jihad. Tens of thousands were killed before Clan Snow Raven arrived and conducted an Orbital Bombardment campaign against the planet's cities. Afterword, the Draconis Combine quarantined the planet for a time before deciding that the plague was too dangerous and untreatable and chose to sterilize the entire planet with two weeks of sustained nuclear strikes, just to make sure that nobody would ever try to visit the planet again. Part of why this is so infamous is because the Black Thorn mercenaries were last seen on Galedon V... and it wasn't until one of the writers wanted to use them again that someone realized they were on the planet when all of the above happened. The line developer declared that they were killed somewhere along the line.
Word of Blake is responsible for a staggering number of NBC weapon violations. For starters, the Redburn Virus is a strain of flu that is much more lethal than normal influenza, and seems to be semi-targeted (it killed war hero Andrew Redburn, but none of the people at his deathbed).
There's also the Necromo Nightmare, a virus that creates Plague Zombies which was released onto the world by Word of Blake. The virus attacks higher brain functions, causing Death of Personality and leading the victim to mindlessly attack anything that isn't infected (presumably detected via pheromones or similar) as a Technically-Living Zombie. There are some horrific implications that even wearing Powered Armor isn't proof against the virus, based on the presence of infected Protomech squads.
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In Beavis and Butt-Head Do America, there's the X-5 Unit, a top-secret man-made virus powerful enough to wipe out five states in five days. Dallas Grimes steals the unit and uses Beavis and Butt-Head as unwitting mules to carry the unit holding it to Washington D.C. on the promise of being able to have sex with her. Making this worse is that the casing has a flaw that if struck wrong could shatter and release the virus instantly.
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The variola chimera virus in The Division is one of these. The guy who made it contaminated currency with it, then spent said money during Black Friday, hence one of the nicknames being the 'Dollar Flu.' The creator is later found to be dead from his own plague, but a rogue Division agent steals his equipment and kidnaps a virologist so he can make his own plagues.
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The Greening Wars has an interesting example in the prologue. The warlord who had the viruses created wanted them to be disabling but non-lethal, to allow relatively bloodless conquests of crippled armies. Unfortunately, the Mad Scientist he hired to make the plagues believed that crippling the enemy wasn't enough, and found a way to make the viruses harmless in testing but be lethal in the field.
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Motherland: Fort Salem: Witchplague is a bioengineered infection that only affects people who have witch DNA. It was made by the Camarilla to destroy them all.
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In Consider Her Ways, a biochemist decides to create an artificial virus that will wipe out all brown rats. It goes about the way you'd expect and ends up infecting humans, but for some reason, most females are immune, resulting in a planet-wide Gendercide.
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In Legends of Dune, there's the Omnius Plague, released by the Thinking Machines against the League worlds. It wasn't actually designed by machines but by an exiled Tlulaxa scientist. The plague ends up devastating the human worlds, killing billions, and mutates into an even deadlier form on Rossak. While a cure is never discovered, Doctors Mohandas Suk and Raquella Berto-Anirul discover that spice can be used to resist the effects of the plague. As a result, the entire known galaxy is now dependent on spice for survival.
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In Sliders, one world is suffering from the after-effects of one such plague being accidentally released and wiping out the vast majority of men in the world. With all of the world becoming a Lady Land, the two new superpowers (US and Australia) are in competition for population growth, each attempting to subvert the breeding efforts of the other and kidnap highly-"productive" men. Strangely enough, artificial insemination is never attempted, even though it would be an obvious answer.
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One Piece: Queen, the Plague of the Animal Kingdom Pirates, derives his nom de plume from his ability to craft artificial diseases and viruses fashioned in bullets he calls "Excitement Bullets"note Plague Rounds in the English translation which infect the victims with highly contagious viruses. He has shown two: Mummy (which causes the target to burn with fever and dry up like a mummy) and Ice Demon (which turns the afflicted in a cold-exuding oni-like creature which can infect others through bite like a zombie).
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In I Am Legend, the infection that wiped out most humans was the result of a supposed Cure for Cancer that ended up going horribly wrong.
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Star Trek: New Frontier has the Redeemer virus, a plague engineered by the Redeemers and carried in their High Priests' blood, so that any non-natural death wipes out everything on the planet he died on within a few days. Naturally, said High Priests are stationed on newly "redeemed" planets, and occasionally (as in Dark Allies) used as a weapon of influence.
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The virus in Planet Explorers's campaign mode was engineered by the Pajans for a war that devastated Maria. While the planet's native species have learned to live with it, the player and their colonist friends soon have a plague on their hands.
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In X-Men, the Legacy Virus was originally engineered by Apocalypse in one Bad Future to kill off the remaining non-mutant humans. When Stryfe got a hold of it, he modified it so that it would target mutants instead. After it was unleashed however, it didn't take long before it mutated and started infecting baseline humans as well. If it hadn't been cured with the Heroic Sacrifice of Colossus (distributing the cure to the virus through his body would be fatal and he knew it), it would have wiped out all of humanity.
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The Stand: The "super-flu" which kills 99% of the world population nearly overnight was the result of military weapons experiments in the United States and was released when a lab accident caused it to be spread throughout the military base it was being stored. Later in the book, the demonic Randall Flagg reveals that other man-made viruses such as super-Ebola are in the works to kill the remaining members of the "good" side of humanity. It gets worse (morally speaking) — not only did the U.S. accidentally get itself horribly infected, when the military officers in charge of the base where the accident happened decide that there's no putting the cat back in the bag, they order operatives in Europe and Asia to purposefully release the plague over there, under the "if we go down, we're taking you all with us" theory. They note that the operatives think the containers they're supposed to open contain radioactive particles for use in testing the ability of satellites to track them, or something. In The Dark Tower, however, Flagg actually takes credit for the plague himself, though he's silent on the details — he was probably the one responsible for the "accident", but he may or may not have had anything to do with its creation.note It should be noted that Flagg has no problem accepting credit for deeds, items, and events that are not actually his design. At one point, when talking about his many names, he muses that he's been called Maerlyn (All-World's version of Merlin), but "who cares, because I was never that one, though I never denied it either."
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Magic: The Gathering has Mad Scientist characters create these from time to time. Yawgmoth released plagues just to see what would happen while the Simic Combine did the same thing to start life on Ravnica all over in their design.
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The Tunnels series has Dominion, a strain of influenza genetically engineered by the Styx into a super-plague that will kill everyone on the planet's surface, allowing those living Beneath the Earth to rise up and take their place.
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In Victoria, the US population is decimated by the N'Orleans Flu, a disease apparently created by some bright kids in a garage just to see if they could. Later, after the Muslims all unite to invade Boston (don't ask) and are driven off, there's a prisoner exchange in which both sides expose their prisoners to engineered plagues before turning them over. The Victorians wisely quarantine their returned prisoners, and the death count is controlled, while the Arabic population is reduced by millions.
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In the Ravenloft campaign, a common health problem among citizens of Valachan is white fever; while rarely lethal (fatalities occur now and then) symptoms include weakness, pale skin, chills, night terrors, and sudden loss of weight. In truth, this is not a disease at all. The darklord of Valachan and most of his servants are vampires, and white fever is something they invented to explain the weakness that befalls victims who they feed on, but don't kill (which is most of them, actually; they rarely have a need to create more vampires).
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In Rainbows End, the Sunrise Plague was an artificial pseudomimivirus released by a cult, and the "second worst Euro-terror of the decade". A large part of the book revolves around the search for a new virus designed not to kill, but for mind control.
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Plague Inc. has the Bio-Weapon. Its distinguishing trait from other disease types is high and constantly increasing lethality. This has to be managed to prevent it from killing hosts faster than it can infect others. Additionally, high lethality also makes it more frightening, which means it tends to get the world funding cure research faster. In addition, the Simian Flu from Dawn of the Planet of the Apes is an option.
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Bloody Zombies uses this as a big plot twist at the end of the game; it turns out the zombie virus that decimated most of London is artificially created and unleashed by the K.R.O.N.O.S Corporation in an attempt to cleanse humanity and put a stop to all wars, with the various different zombies you fought throughout being their "upgraded prototypes".
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Area 51: The Mission, an alien front organization, genetically alters the bubonic plague to unleash it and cull humanity when we're deemed as a threat. It's stated the original mass bubonic plague outbreak in the 1200s is their work too, with the same goal. The protagonists only barely manage to stop it.
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In Friendship is Optimal, a depressed programmer came this close to unleashing a highly contagious plague that would lock everyone's facial muscles into a "smile". You see, he wrote an AI, showed it a bunch of photos of smiling faces, and said "make everyone in the world smile". Luckily, Celest-AI stepped in before the virus could actually be released.
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The titular Syphon Filter is a man-made disease that can be custom-tailored (the "Filter" part of the name) to target only specific groups (in other words, it's designed for racial genocide).
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Warhammer 40,000:
One form of the world-killing Exterminatus procedure uses a virus that breaks down all living tissue, reducing the biosphere to a mass of extremely flammable matter. While useful on planets with lots of minerals or infrastructure, agriworlds become useless to the Imperium, and they've stopped using them ever since they figured out virus bombings powered up Nurgle, the god of disease and decay.
One Dark Eldar Archon is known to be narcissistic to the point where he once unleashed a virus on a planet that changed every living thing's face into a copy of his own.
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In Shadowrun, Ares engineered Strain III Flourescing Astral Bacteria to fight the insect spirit infestation of Chicago. Strains I and II merely glow in the presence of mana and dual-natured creatures, while FAB3 actively seeks out and consumes mana. Like all bioweapons, it went after more than just its intended target and devastated the ghouls of Cabrini Green and active mages. Pockets of FAB3 are scattered throughout Chicago, waiting for a nice juicy mage, spirit, or paracritter to walk by and announce its presence to them.
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A Transformers: Animated tie-in comic reveals that in this continuity, cosmic rust was a bioweapon created by the Decepticon chemist, Oil Slick. He is not at all concerned about Decepticons who are infected with chemical agent and only begins working on a treatment after he himself is infected.
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In Star Wars: Legacy, the Sith scientist Vul Isen engineers a plague lethal enough to wipe out all life on a planet within a matter of days. He unleashes it on Dac as part of the Sith's plan to exterminate the Mon Calamari, and later uses it to wipe out all life on Da Soocha as well. He would have unleashed it on Utapau too, had Cade Skywalker not tracked him down and killed him.
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Judge Dredd: There have been many instances in the comic where hostile factions resorted to biological warfare by spreading lab-manufactured diseases among enemy populations. The worst one was probably the Chaos Bug, a Hate Plague designed by leftover factions of East Meg One that started an epidemic in Mega City One resulting in the death of about 85% of the population.
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The Exsurgent virus in Eclipse Phase is a bio-nanotech or digital virus created by the ETI that mutates people into hideous abominations, or at the very least gives them Psychic Powers and a mental disorder or two. There are also a few more mundane designer plagues too.
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Doctor Who:
In "Planet of the Daleks", the Daleks decide to use this to rid the planet they are enslaving of Thal intruders.
Inverted in the episodes "The Empty Child" and "The Doctor Dances". London has been infected by a virus that turns humans into gas mask wearing zombie creatures. As it turns out, it's not a plague at all, but in fact a cloud of nanogenes that are actually supposed to heal the ill and wounded. But since the nanogenes in question are alien and have never seen humans before, they just turn all the humans they encounter into what they think humans are supposed to look like: a dead boy wearing a gas mask, the first 'human' they've encountered. They end up fixing it by having the nanogenes infect the mother of the dead boy: by recognizing her as the parent, they're able to correct themselves and cure the zombies.
An unintentional example in "The Pyramid at the End of the World", in which a pair of scientists are running routine tests. Unfortunately, one of them had her glasses accidentally broken by her husband, and the other one is suffering from a bad hangover from the night before. The latter ends up messing up a decimal point, while mixing the latest batch of chemicals. This results in a highly voracious flesh-eating bacteria that threatens to wipe out literally all life on Earth within a year, should it escape the lab.
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Part of the world-ending crisis in... well, Crysis 2 was a very, very nasty disease which causes people to literally disintegrate over a period of weeks. Since the first cases came from advanced nano- and biotechnology firm Crynet's quarters, fingers were quickly pointed. Turns out they were wrong; the 'Spore,' as the virus came to be called, was a creation of the alien Ceph, intended to not only kill humans but reduce them to environmental-friendly sludge so as to minimize the ecological impact when they finally took back their world.
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In Deus Ex, the Gray Death is a plague that is ravaging the planet, with the Orwellian government maintaining full control of the vaccine that keeps people alive, which is believed to be difficult to make. It is later revealed that this is really a plan to control the world's populace, killing the poor and only keeping around people who the Majestic 12 find useful. The Gray Death is actually man-made Nanomachines that integrate themselves into human cells, which the body then reject, eventually killing them. The vaccine (called Ambrosia) is simply ROM modules that attach themselves to the nanites to deactivate them, and as such it's more of a cure than a traditional vaccine, and reinfection is possible at a later date. The very few immune people are those who are nano-augmented (like the player) because they already contain nanomachines in their cells.
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In the Circle of Magic novel Briar's Book, a mage trying to develop weight-loss potions dumped failed efforts in the sewers rather than disposing of them properly. The magical potions mixed with each other and the filth, creating the Blue Pox, a magical disease that caused its victims to waste away. The original potion was engineered to resist a common medicine (so that users could treat their headaches, for example, without compromising their weight loss), which now has tragic consequences.
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JAG: In "Embassy" the Sudanese Ambassador has stolen vials of Ebola from a U.S. lab, intending to use it for political purposes in Sudan.
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In Derailed (2002), Galina's ill-gotten gain is three vials of SP-43, an ultra-virulent strain of smallpox cultured in fluorescent green serum that contains several other pathogens.
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In Oryx and Crake, an artificially created disease wipes out most of the human race.
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In Heavy Object, the Einherjar project is a molecular motor that replicates the effect of rabies, but with a faster incubation rate and increased rate of spread.
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The Dawnhounds kicks off with the theft of an engineered fungal plague, found in the ruins of an ancient biolab, and the plague vials serve as the story's MacGuffin until the spores get out and the story takes a turn for the horrifying.
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The gene plagues you can use to cull the population with in Fate of the World are this.
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The Clench/Ebola Gulf-A from Batman: Contagion, which Robin and many other Gothamites contract, was originally unleashed in Gotham City by the Saint Duma's Order but later revealed to have been created by Ra's al Ghul.
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The zombie plague in Shellshock 2 was created to end The Vietnam War (and any war thereafter), but after the US military rejected it, the creator releases it anyway so as to prove its power and to force them to make a deal with him for the cure. The player character ends up with a choice between accepting the virus creator's offer (while hoping that there will be an opportunity to punish him after he provides the cure) or simply shooting him and let the plague go on. (Neither ending is exactly bright and cheery.)
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In Last and First Men, the second men eventually created a virus designed to destroy the Martians (themselves sentient clouds of microbes), but the side effects of the plague lead to the second men's downfall and replacement by the third men.
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The 4400: A slight variation. In the two-part story "The Fifth Page" and "Mommy's Bosses", Kevin Burkhoff determines that the apparent disease afflicting the 4400 is not a disease at all but an unintended side effect of the promicin inhibitor that is given to them at their quarterly checkups. Promicin is a previously unknown neurotransmitter which gives the 4400 their abilities. The inhibitor builds up in the lymph nodes until it reaches toxic levels, severely damaging the immune system and ultimately resulting in death.
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Synthetic Plague
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One Chance is all about this, as the player takes the role of a researcher whose team has inadvertently created an airborne pathogen that will kill all life on Earth in six days.
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d20 Modern: In the d20 Apocalypse setting Plague World, a species of alien invaders unleash a deadly engineered virus on humankind. Too bad for them, the virus mutated, so when they landed to finish the surviving humans, they suffered from massive casualties caused by their own weapons.
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Synthetic Plague
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The Hoffan Plague spread by Micheal in Stargate Atlantis in an effort to cripple the Wraith. For reference, a group called the Hoffans created a drug that, if taken, would render one immune to Wraith feeding, and indeed poisonous to the Wraith. It also had a 50% mortality rate among those who took it; they were aware of this, and took it anyway. The Wraith slaughtered the survivors. Micheal got a hold of it, turned it into a disease (albeit with "only" a 33% mortality rate), and spread it to as many human populations as he could in order to poison the Wraith's food supply.
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Synthetic Plague
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In Metaltown, the corn flu was created by accident when scientists tried to create longer-lasting crops after drought led to famine. While not contagious by normal means, it's in enough food that buying anything processed is a great risk, and being in the food-testing facility is a guaranteed death sentence.
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Synthetic Plague
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User RandomJ of SpaceBattles.com created Neococcus ecoclastus, a.k.a. "Little Boy", a bioweapon purpose-built to wipe out entire ecologies. It's extremely contagious, highly deadly, and resistant/immune to basically anything that kills bacteria, up to and including liberal application of fire. Symptoms include conversion of most of your biomass into various types of plastic and rapid death from several particularly deadly chemical compounds. Worst of all, it's made by combining traits of real organisms.
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Synthetic Plague
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In the Myst franchise, devastating plagues are a recurring theme in the history of the D'ni civilization and all can be traced back to a single source: King Alsendahl, who created a plague to exterminate an alien race who he believed were preparing to attack, only for it to jump the species barrier and nearly wipe out his own people. In atonement for this, he had himself and all known sources of the disease permanently sealed inside his palace. Mutations of the plague popped up every few centuries thereafter, and have been major plot devices in two of the tie-in novels: in The Book of Ti'ana, the vengeful criminals Veovis and A'Gaeris release a plague onto the D'ni city, destroying its population almost completely, and in The Book of D'ni, a strain that had been rendered harmless to the D'ni proved fatal and virulent to their crueler cousins, the Tehranee, resulting in the destruction of that civilization.
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Synthetic Plague
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Star Wars Legends:
The overarching plot of the first four novels of the X-Wing Series concerns the Krytos virus. Ysanne Isard, the Director of Imperial Intelligence and de facto ruler of the Galactic Empire, concludes that the diminished Empire is in no state to defend the capital world of Coruscant, and so decides to use the entire planet as a trap for the New Republic by seeding it with a plague synthesized from several of the galaxy's most lethal and infectious diseases. As per her specifications, the results are 100% lethal (Gamorreans get to the point where moving their bodies ruptures their skin, while Quarrens liquify) and highly contagious... except humans and Bothans are wholly immune, and the disease is easily treatable with bacta, an expensive medicine that is commonly used to treat battlefield injuries. This ensures that by taking the planet meant to firmly establish their legitimacy, the Rebels will inherit a humanitarian disaster that will bankrupt them to combat (a situation made worse when Isard seizes the only planet in the galaxy that produces bacta), while also stirring up anti-human resentment among the other races of the Alliance (which is exacerbated by the Bothans, being a species of politicking opportunists). Fortunately for the New Republic, Rogue Squadron is able to capture Coruscant two weeks ahead of Isard's timetable and in a way that destroys some of the virus reserves, while technicians also come up with alternative treatments that are cheaper and require less bacta. Meanwhile, the fact that Krytos was so lethal meant that infectees often died before spreading it to its fullest extent.
The second arc of Young Jedi Knights features a similar plague... aimed at humans and humans only. The Diversity Alliance's insane leader seeks to find and unleash it. Later, the characters discover that the Empire had created plagues specifically targeting each individual species. The asteroid containing the viruses is destroyed, though the fight that ensues does end up releasing some viruses, which infect both the father of one of the knights and the leader of the Diversity Alliance. The father sacrifices himself to ensure that the asteroid blows up. The leader tries to fly to Coruscant to spread the disease, but her disillusioned number two subdues her and flies her to parts unknown to die.
During the New Jedi Order series, the war against the Yuuzhan Vong goes badly enough that a synthetic plague called "Alpha Red" is created, which specifically targets the Vong and their Organic Technology, killing them within days. It is deemed unethical and condemned by the heroes, but still gets released here and there by certain elements in the Alliance. The Vong weren't above using their own synthetic plagues, including one nasty variant released on Ithor that also had the side effect of over-oxygenating the atmosphere, so anything surviving the plague had global firestorms to look forward too. One of the many arguments against Alpha Red was that it might spur the Vong to retaliate in kind, potentially sterilizing the entire galaxy.
Thousands of years before these examples, the ancient Sith Alchemists perfected the Rakghoul Plague, a debilitating infection that would irrevocably transform its victims into the eponymous mutant beasts. Nearly every humanoid species (and quite a lot of others besides) are at risk, ensuring that rakghouls are an ever-present threat once an infection begins.
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Dimension X's "Pebble in the Sky": In a change from the original, Dr Shekt is one of the biologists who created the virus that will kill the Outsiders (humans that aren't Earth-natives). He's motivated to do so because he is older and in violation of The Sixty; mandatory euthanasia.
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Synthetic Plague
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"Manticore" in Call of Duty: Advanced Warfare is a bioweapon created by ATLAS to kill anyone not inoculated by them. The inoculation is given to all ATLAS personnel, both current and former. In Exo Zombies, it ends up causing a Zombie Apocalypse.
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Synthetic Plague
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In "How Things Smurf" from The Smurfette Village, the "Blue Plague"note no relation to the disease from the episode of the same name in The Smurfs (1981) was manufactured by either Gargamel or the new villain Asmoday to wipe out all the Smurfs and Smurfettes at once, although because Papa Smurf had put up a magical force field to keep the plague from spreading, several Smurfs were spared this fate and would go on to build a whole new Smurf Village elsewhere.
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Synthetic Plague
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The main antagonist of Trauma Center (Atlus) leads a cult which believes that modern medicine leads humanity to lead unnatural lives. They operate by spreading GUILT, a pathogen engineered to kill their patient. The sequels also deal with artificial pathogens with differing origins and intent of creation.
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Synthetic Plague
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The Dirk Pitt Adventures novel Vixen 03 involves a race to stop the release of a bioweapon that is projected to be able to kill up to 98% of all human life.
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Synthetic Plague
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The Viral Factor revolves around a prototype virus being smuggled into Malaysia and being developed in a top-secret lab by a terrorist mastermind who intends to spread it worldwide. The hero, Jon, has a few weeks left to live because of a bullet in his brain and must prevent the virus' release before then.
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The Satan Bug involves the protagonist trying to save humanity from annihilation by preventing the release of such a doomsday disease.
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One episode of Diagnosis: Murder has RZ1765, a genetically modified strain of smallpox with an 8-hour incubation period and the potential to wipe out a small city. It gets stolen, along with the antigen that counteracts it, from a biological research company and by a series of unlucky coincidences infects an unfortunate burglar who expires inside Mark's home and spreads it to Mark and Jessie, although thankfully Mark recognises the smallpox symptoms on the burglar's corpse and sets up a quarantine before anyone else gets infected. The rest of the episode then becomes a race against time to figure out who originally stole it and what they did with the antigen.
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Synthetic Plague
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In L: change the WorLd, Blue Ship, a terrorist group, manufactures an extremely dangerous virus in order to wipe out humanity and restore balance in the ecosystem.
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Synthetic Plague
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The Babylon 5 episode "Deathwalker" has Jha'dur, a Dilgar war criminal infamous for exterminating a whole planetary population with Stafford's Plague (among many other things).
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In The Wild Boy, the virus created and released by the Lindauzi. Everyone thought they were humanity's saviors, but later, Ilox found the truth.
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In Quarantine (2008), the rabies infecting everyone in the building is revealed to be a "super-rabies" stolen by an apocalyptic cult.
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Ashes of Empire: A good chunk of Imperial Night deals with Lyonesse's efforts to keep out the "Barbarian Plague", an Imperial bioweapon accidentally released when reavers raided biowarfare labs (placed on the Empire's borders to keep them well away from inhabited planets) looking for technology to scavenge.
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In Revolution, The Patriots purposely use a designed, targeted version of typhus against people with mental or biochemical disorders. They're not very nice people.
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Some of the graffiti in Left 4 Dead written by the unseen survivors has them making up theories that the Green Flu was made by the government as a biological weapon or some sort of conspiracy theory. If this is true or not is, for the time being, left ambiguous.
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In the Plague Year Series, the nanotech plague/Grey Goo that befalls humanity was originally intended as a cure for cancer; it worked by dismantling the cancer cells. By the time they figured out that it dismantled a little too well, it had already escaped containment.
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In the Double Helix series (set primarily during the Star Trek: The Next Generation era), a shadowy malefactor sponsoring medical research appears to be purposely infecting different planets in order to test out the most efficient way to send out viruses to kill off as many Federation citizens as possible.
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Starsnatcher has the Plague. It originates from a Mechanical Abomination and has originally been designed to infect computer systems. First, it uses radio waves to spread as far as possible and infect anything mechanical it can get its hands on, shutting off any infrastructure that could help you. Then, it infects nanofactories and forces them to print biological pathogens to infect organic life. Any life infected by it is going to turn into super-zombies with way more eyes, mouths, or fingers than what is healthy and a desire to kill/infect as much as possible.
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The following is a list of statements referring to the current page from other pages.

 Synthetic Plague
processingCategory2
Apocalyptic Index
 Synthetic Plague
processingCategory2
Futuristic Tech Index
 Synthetic Plague
processingCategory2
Index Syndrome
 Synthetic Plague
processingCategory2
Indexitis
 Synthetic Plague
processingCategory2
Make My Index Live!
 Synthetic Plague
processingCategory2
Older Than Television
 Synthetic Plague
processingCategory2
Speculative Fiction Tropes
 BNA: Brand New Animal / int_c8146c52
type
Synthetic Plague
 High School Fleet / int_c8146c52
type
Synthetic Plague
 Highlander: The Search for Vengeance / int_c8146c52
type
Synthetic Plague
 Sound of the Sky / int_c8146c52
type
Synthetic Plague
 Batman: Endgame (Comic Book) / int_c8146c52
type
Synthetic Plague
 Batman: Year 100 (Comic Book) / int_c8146c52
type
Synthetic Plague
 Shakara (Comic Book) / int_c8146c52
type
Synthetic Plague
 Spider-Man 2099 (Comic Book) / int_c8146c52
type
Synthetic Plague
 The Invisibles (Comic Book) / int_c8146c52
type
Synthetic Plague
 X-Men: Blue (Comic Book) / int_c8146c52
type
Synthetic Plague
 The Dilgar War / Fan Fic / int_c8146c52
type
Synthetic Plague
 The Last War World War 3 / Fan Fic
seeAlso
Synthetic Plague
 Akko Kagari Universe (Fanfic) / int_c8146c52
type
Synthetic Plague
 Beyond the Outer Gates Lies... A high school library? (Fanfic) / int_c8146c52
type
Synthetic Plague
 Eroninja (Fanfic) / int_c8146c52
type
Synthetic Plague
 Let the Darkness Bring Us Into the Light (Fanfic) / int_c8146c52
type
Synthetic Plague
 lost in the infinite lights (Fanfic) / int_c8146c52
type
Synthetic Plague
 The Smurfette Village (Fanfic) / int_c8146c52
type
Synthetic Plague
 Contagion (2011) / int_c8146c52
type
Synthetic Plague
 Dead Air (2009) / int_c8146c52
type
Synthetic Plague
 Derailed (2002) / int_c8146c52
type
Synthetic Plague
 I Am Legend / int_c8146c52
type
Synthetic Plague
 L: change the WorLd / int_c8146c52
type
Synthetic Plague
 On Her Majesty's Secret Service / int_c8146c52
type
Synthetic Plague
 Quarantine (2008) / int_c8146c52
type
Synthetic Plague
 Resident Evil: Extinction / int_c8146c52
type
Synthetic Plague
 Spawn (1997) / int_c8146c52
type
Synthetic Plague
 The Cassandra Crossing / int_c8146c52
type
Synthetic Plague
 The Viral Factor / int_c8146c52
type
Synthetic Plague
 Train to Busan / int_c8146c52
type
Synthetic Plague
 28 Days Later / int_c8146c52
type
Synthetic Plague
 28 Weeks Later / int_c8146c52
type
Synthetic Plague
 Ultraviolet (2006) / int_c8146c52
type
Synthetic Plague
 Wolf Warrior / int_c8146c52
type
Synthetic Plague
 Evillious Chronicles (Franchise) / int_c8146c52
type
Synthetic Plague
 Highlander (Franchise) / int_c8146c52
type
Synthetic Plague
 The Hohenzollern Empire (Lets Play) / int_c8146c52
type
Synthetic Plague
 Heavy Object / int_c8146c52
type
Synthetic Plague
 The Death Mage Who Doesn't Want a Fourth Time / int_c8146c52
type
Synthetic Plague
 An Examination of Extra-Universal Systems of Government / int_c8146c52
type
Synthetic Plague
 Aristoi / int_c8146c52
type
Synthetic Plague
 Ashes of Man / int_c8146c52
type
Synthetic Plague
 Black Tide Rising / int_c8146c52
type
Synthetic Plague
 Blood Music / int_c8146c52
type
Synthetic Plague
 Dragonriders of Pern / int_c8146c52
type
Synthetic Plague
 Everland / int_c8146c52
type
Synthetic Plague
 Feverwake / int_c8146c52
type
Synthetic Plague
 Freeway Fighter / int_c8146c52
type
Synthetic Plague
 Hc Svnt Dracones / int_c8146c52
type
Synthetic Plague
 Heavy Object / int_c8146c52
type
Synthetic Plague
 Jacob's Ladder Trilogy / int_c8146c52
type
Synthetic Plague
 Keeper of the Lost Cities / int_c8146c52
type
Synthetic Plague
 Line of Delirium / int_c8146c52
type
Synthetic Plague
 Mass Effect Annihilation / int_c8146c52
type
Synthetic Plague
 Metaltown / int_c8146c52
type
Synthetic Plague
 Newsflesh / int_c8146c52
type
Synthetic Plague
 Orange Tempest / int_c8146c52
type
Synthetic Plague
 Orthogonal / int_c8146c52
type
Synthetic Plague
 Oryx and Crake / int_c8146c52
type
Synthetic Plague
 Quazi / int_c8146c52
type
Synthetic Plague
 Rainbows End / int_c8146c52
type
Synthetic Plague
 Remember To Always Be Brave / int_c8146c52
type
Synthetic Plague
 Rumo & His Miraculous Adventures / int_c8146c52
type
Synthetic Plague
 Space Cadet (Rvbomally) / int_c8146c52
type
Synthetic Plague
 The Day of the Triffids / int_c8146c52
type
Synthetic Plague
 The Death Mage Who Doesn't Want a Fourth Time / int_c8146c52
type
Synthetic Plague
 The Lovers / int_c8146c52
type
Synthetic Plague
 The Lunar Chronicles / int_c8146c52
type
Synthetic Plague
 The Otherworld / int_c8146c52
type
Synthetic Plague
 The Silmarillion / int_c8146c52
type
Synthetic Plague
 The Stars Are Cold Toys / int_c8146c52
type
Synthetic Plague
 The Underland Chronicles / int_c8146c52
type
Synthetic Plague
 This Book Is Full of Spiders: Seriously, Dude, Don't Touch It / int_c8146c52
type
Synthetic Plague
 Twig / int_c8146c52
type
Synthetic Plague
 X-Wing Series / int_c8146c52
type
Synthetic Plague
 TheSatanBug
seeAlso
Synthetic Plague
 Assassination Classroom (Manga) / int_c8146c52
type
Synthetic Plague
 Evillious Chronicles (Music) / int_c8146c52
type
Synthetic Plague
 SAYER (Podcast) / int_c8146c52
type
Synthetic Plague
 The Lords of Ruin (Roleplay) / int_c8146c52
type
Synthetic Plague
 All of Us Are Dead / int_c8146c52
type
Synthetic Plague
 Blake's 7 / int_c8146c52
type
Synthetic Plague
 Counterpart (2018) / int_c8146c52
type
Synthetic Plague
 Dark Angel / int_c8146c52
type
Synthetic Plague
 Diagnosis: Murder / int_c8146c52
type
Synthetic Plague
 Extinct / int_c8146c52
type
Synthetic Plague
 Helix / int_c8146c52
type
Synthetic Plague
 Intelligence (2014) / int_c8146c52
type
Synthetic Plague
 Legends of Tomorrow / int_c8146c52
type
Synthetic Plague
 Limitless / int_c8146c52
type
Synthetic Plague
 Motherland: Fort Salem / int_c8146c52
type
Synthetic Plague
 Supergirl (2015) / int_c8146c52
type
Synthetic Plague
 Travelers / int_c8146c52
type
Synthetic Plague
 Westworld / int_c8146c52
type
Synthetic Plague
 After the Bomb (Tabletop Game) / int_c8146c52
type
Synthetic Plague
 Blue Planet (Tabletop Game) / int_c8146c52
type
Synthetic Plague
 Degenesis (Tabletop Game) / int_c8146c52
type
Synthetic Plague
 Eclipse Phase (Tabletop Game) / int_c8146c52
type
Synthetic Plague
 Pandemic (Tabletop Game) / int_c8146c52
type
Synthetic Plague
 Renegade Legion (Tabletop Game) / int_c8146c52
type
Synthetic Plague
 Rocket Age (Tabletop Game) / int_c8146c52
type
Synthetic Plague
 ARMA (Video Game) / int_c8146c52
type
Synthetic Plague
 Bloody Zombies (Video Game) / int_c8146c52
type
Synthetic Plague
 CT Special Forces (Video Game) / int_c8146c52
type
Synthetic Plague
 Civilization: Call to Power (Video Game) / int_c8146c52
type
Synthetic Plague
 Code 7 (Video Game) / int_c8146c52
type
Synthetic Plague
 Crysis (Video Game) / int_c8146c52
type
Synthetic Plague
 DUSK-12 (Video Game) / int_c8146c52
type
Synthetic Plague
 Deus Ex (Video Game) / int_c8146c52
type
Synthetic Plague
 Dragon Riders: Chronicles of Pern (Video Game) / int_c8146c52
type
Synthetic Plague
 Dreamfall Chapters (Video Game) / int_c8146c52
type
Synthetic Plague
 Dying Light (Video Game) / int_c8146c52
type
Synthetic Plague
 Fallout (Video Game) / int_c8146c52
type
Synthetic Plague
 Instinct (Video Game) / int_c8146c52
type
Synthetic Plague
 Iron Helix (Video Game) / int_c8146c52
type
Synthetic Plague
 Michigan: Report From Hell (Video Game) / int_c8146c52
type
Synthetic Plague
 NanoBreaker (Video Game) / int_c8146c52
type
Synthetic Plague
 Soldier of Fortune (Video Game) / int_c8146c52
type
Synthetic Plague
 Spore Creatures (Video Game) / int_c8146c52
type
Synthetic Plague
 Star Trek: 25th Anniversary (Video Game) / int_c8146c52
type
Synthetic Plague
 State of Decay (Video Game) / int_c8146c52
type
Synthetic Plague
 Syphon Filter (Video Game) / int_c8146c52
type
Synthetic Plague
 Trauma Center (Atlus) (Video Game) / int_c8146c52
type
Synthetic Plague
 Zombie Infection (Video Game) / int_c8146c52
type
Synthetic Plague
 Bloodbound (Visual Novel) / int_c8146c52
type
Synthetic Plague
 Gamer Poop (Web Animation) / int_c8146c52
type
Synthetic Plague
 Genocide Man (Webcomic) / int_c8146c52
type
Synthetic Plague
 Viral By Committee (Webcomic) / int_c8146c52
type
Synthetic Plague
 Weapon Brown (Webcomic) / int_c8146c52
type
Synthetic Plague
 Taerel Setting (Website) / int_c8146c52
type
Synthetic Plague
 Animals (2016) / int_c8146c52
type
Synthetic Plague
 Centurions / int_c8146c52
type
Synthetic Plague
 Isle of Dogs / int_c8146c52
type
Synthetic Plague
 Pantheon / int_c8146c52
type
Synthetic Plague
 Spiral Zone / int_c8146c52
type
Synthetic Plague
 Ever17 (Visual Novel) / int_c8146c52
type
Synthetic Plague